ESR1 | OmnibusX

Name	Number of supported studies	Average coverage
fibroblast	9 studies	28% ± 11%	Explore
adipocyte	8 studies	33% ± 8%	Explore
macrophage	6 studies	29% ± 8%	Explore
hepatocyte	4 studies	61% ± 27%	Explore
smooth muscle cell	4 studies	28% ± 13%	Explore
retina horizontal cell	3 studies	35% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	31% ± 7%	Explore
endothelial cell	3 studies	24% ± 10%	Explore
glutamatergic neuron	3 studies	39% ± 25%	Explore
alveolar macrophage	3 studies	20% ± 4%	Explore
plasma cell	3 studies	40% ± 10%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ESR1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	2190.29	180 / 180	87%	26.38	376 / 430
breast	100%	4897.18	459 / 459	77%	147.96	866 / 1118
uterus	100%	19022.60	170 / 170	31%	12.10	140 / 459
thymus	100%	800.71	652 / 653	19%	4.93	116 / 605
prostate	100%	1995.15	244 / 245	12%	1.15	58 / 502
lung	99%	612.39	575 / 578	6%	1.07	74 / 1155
kidney	99%	469.45	88 / 89	1%	0.15	12 / 901
adipose	100%	728.99	1202 / 1204	0%	0	0 / 0
blood vessel	100%	905.04	1330 / 1335	0%	0	0 / 0
liver	96%	1655.90	216 / 226	4%	0.44	15 / 406
spleen	99%	514.38	239 / 241	0%	0	0 / 0
adrenal gland	98%	493.50	254 / 258	0%	0.07	1 / 230
bladder	90%	680.05	19 / 21	3%	0.38	15 / 504
muscle	80%	334.56	645 / 803	0%	0	0 / 0
heart	80%	292.04	689 / 861	0%	0	0 / 0
skin	72%	238.80	1302 / 1809	0%	0	0 / 472
esophagus	65%	234.78	939 / 1445	1%	0.11	1 / 183
intestine	61%	175.01	587 / 966	0%	0.05	2 / 527
stomach	42%	117.49	152 / 359	0%	0	0 / 286
pancreas	38%	76.07	125 / 328	1%	0.05	1 / 178
brain	31%	113.89	812 / 2642	0%	0	0 / 705
tonsil	0%	0	0 / 0	20%	3.01	9 / 45
peripheral blood	6%	10.69	58 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.33	3 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0060527	Biological process	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO_0001547	Biological process	antral ovarian follicle growth
GO_0071392	Biological process	cellular response to estradiol stimulus
GO_0060068	Biological process	vagina development
GO_0010629	Biological process	negative regulation of gene expression
GO_0060750	Biological process	epithelial cell proliferation involved in mammary gland duct elongation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0051123	Biological process	RNA polymerase II preinitiation complex assembly
GO_0007165	Biological process	signal transduction
GO_1902894	Biological process	negative regulation of miRNA transcription
GO_0050727	Biological process	regulation of inflammatory response
GO_0048144	Biological process	fibroblast proliferation
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0032355	Biological process	response to estradiol
GO_0008209	Biological process	androgen metabolic process
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0060523	Biological process	prostate epithelial cord elongation
GO_0071391	Biological process	cellular response to estrogen stimulus
GO_0060749	Biological process	mammary gland alveolus development
GO_0043433	Biological process	negative regulation of DNA-binding transcription factor activity
GO_0034392	Biological process	negative regulation of smooth muscle cell apoptotic process
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0060065	Biological process	uterus development
GO_0071168	Biological process	protein localization to chromatin
GO_0008584	Biological process	male gonad development
GO_0060687	Biological process	regulation of branching involved in prostate gland morphogenesis
GO_0034121	Biological process	regulation of toll-like receptor signaling pathway
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_1904035	Biological process	regulation of epithelial cell apoptotic process
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0043627	Biological process	response to estrogen
GO_0030518	Biological process	nuclear receptor-mediated steroid hormone signaling pathway
GO_0060745	Biological process	mammary gland branching involved in pregnancy
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0048863	Biological process	stem cell differentiation
GO_0030520	Biological process	estrogen receptor signaling pathway
GO_0002064	Biological process	epithelial cell development
GO_0005634	Cellular component	nucleus
GO_0005654	Cellular component	nucleoplasm
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0000791	Cellular component	euchromatin
GO_0032991	Cellular component	protein-containing complex
GO_0005794	Cellular component	Golgi apparatus
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005829	Cellular component	cytosol
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0034056	Molecular function	estrogen response element binding
GO_0001222	Molecular function	transcription corepressor binding
GO_0042802	Molecular function	identical protein binding
GO_0001223	Molecular function	transcription coactivator binding
GO_0008270	Molecular function	zinc ion binding
GO_0051117	Molecular function	ATPase binding
GO_0030284	Molecular function	nuclear estrogen receptor activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001093	Molecular function	TFIIB-class transcription factor binding
GO_0003682	Molecular function	chromatin binding
GO_0071889	Molecular function	14-3-3 protein binding
GO_0005496	Molecular function	steroid binding
GO_0005516	Molecular function	calmodulin binding
GO_0019899	Molecular function	enzyme binding
GO_0004879	Molecular function	nuclear receptor activity
GO_0001221	Molecular function	transcription coregulator binding
GO_0030331	Molecular function	nuclear estrogen receptor binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0017025	Molecular function	TBP-class protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0019901	Molecular function	protein kinase binding
GO_0008013	Molecular function	beta-catenin binding
GO_0030235	Molecular function	nitric-oxide synthase regulator activity

IV. Literature review

[source]

Gene name	ESR1
Protein name	Estrogen receptor alpha 3,4,5,6,7,8/1068 isoform Estrogen receptor alpha E1-N1-E2-1 variant Estrogen receptor alpha E1-1-2 variant (Estrogen receptor alpha E1-E2-1-2 variant) (Estrogen receptor alpha E1-N2-E2-1-2 variant) Estrogen receptor Alternative protein ESR1 Estrogen receptor 1 (Estrogen receptor protein) Estrogen receptor alpha 2,3,4,5,6,7,8* isoform Estrogen receptor 1 (Estrogen receptor alpha) Hippocampal estrogen receptor alpha isoform TADDI Estrogen receptor alpha Estrogen receptor alpha E1-2 variant (Estrogen receptor alpha E1-E2-2 variant) (Estrogen receptor alpha E1-N2-E2-2 variant) Estrogen receptor alpha splice variant Estrogen receptor (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Estrogen receptor alpha delta 2,3,4,5,6,7/963 isoform Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform Estrogen receptor 1
Synonyms	ESR receptor estrogen NR3A1
Description	FUNCTION: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. . FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 . Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). .; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production . Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor . Binds to ERE and inhibits isoform 1 . .
Accessions	K4Q331 A0A125SXV6 A0A125SXW2 B6DP71 Q9UE35 B6DP75 ENST00000443427.5 [P03372-1] B5TZ79 B6DU66 B5TZ80 ENST00000415488.1 C0L927 L8E8A8 ENST00000206249.8 [P03372-1] C8CJK9 B5TZ82 ENST00000440973.5 [P03372-1] C0LLI8 C9E0F2 A0A4P8D7D1 K4PX46 A0A125SXV7 B0QYW7 ENST00000427531.6 [P03372-4] A0A679EM68 B6DP73 K7R989 C8CJL1 ENST00000456483.3 C8CJL5 B5TKC0 E3WH18 C8CJL0 B5TZ83 B5LY05 C0LLI7 B5TZ81 A0A125SXV9 B6DU69 B6DU67 ENST00000404742.5 C9E0F0 C9E0F1 C7FFR5 C8CJK8 C0LJA7 A0A125SXW3 C0LLI5 C8CJL2 C9E0E9 E3WH19 Q5T5H8 B6DP72 ENST00000406599.5 B6DU70 ENST00000446550.1 C8CJL6 Q9H2M2 B6DP74 C8CJL4 C0LJA9 B5TKC2 B5TZ78 H0Y4W6 P03372 A0A125SXW1 C0LLI9 A0A3G1VCY8 ENST00000427531.6 B5TZ77 Q9H1Z6 B5TKC1 C8CJL3 C0LJA8 C0LLI6 G4XH65 Q9H2M1 C9E0F3 A0A125SXW0 C8CD01 Q0H8T6 K4PXX0 ENST00000338799.9 [P03372-1] B5M0Y2 A0A125SXV8 B6DU68

ESR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review