I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| intestinal crypt stem cell | 3 studies | 24% ± 8% | |
| kidney distal convoluted tubule epithelial cell | 3 studies | 19% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| intestinal crypt stem cell | 3 studies | 24% ± 8% | |
| kidney distal convoluted tubule epithelial cell | 3 studies | 19% ± 1% |
Insufficient scRNA-seq data for expression of VDR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 98% | 1637.02 | 568 / 578 | 97% | 29.72 | 1126 / 1155 |
| breast | 80% | 1322.91 | 367 / 459 | 98% | 32.34 | 1101 / 1118 |
| skin | 100% | 4142.61 | 1809 / 1809 | 76% | 12.21 | 361 / 472 |
| kidney | 98% | 2309.66 | 87 / 89 | 71% | 12.98 | 642 / 901 |
| intestine | 60% | 3215.42 | 578 / 966 | 99% | 52.95 | 521 / 527 |
| bladder | 62% | 642.38 | 13 / 21 | 90% | 25.97 | 453 / 504 |
| adrenal gland | 100% | 2801.26 | 257 / 258 | 47% | 14.86 | 109 / 230 |
| thymus | 69% | 472.62 | 448 / 653 | 77% | 9.60 | 468 / 605 |
| esophagus | 45% | 1059.94 | 654 / 1445 | 99% | 36.19 | 181 / 183 |
| stomach | 42% | 303.31 | 151 / 359 | 98% | 44.62 | 280 / 286 |
| pancreas | 24% | 130.98 | 80 / 328 | 94% | 29.32 | 168 / 178 |
| uterus | 22% | 165.91 | 37 / 170 | 85% | 23.78 | 392 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 24.97 | 44 / 45 |
| peripheral blood | 95% | 1382.35 | 882 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 20.23 | 27 / 29 |
| ovary | 4% | 20.13 | 8 / 180 | 79% | 12.48 | 341 / 430 |
| spleen | 83% | 541.95 | 201 / 241 | 0% | 0 | 0 / 0 |
| prostate | 52% | 374.33 | 128 / 245 | 19% | 1.44 | 96 / 502 |
| blood vessel | 68% | 520.88 | 904 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 66% | 532.46 | 799 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 39% | 304.35 | 315 / 803 | 0% | 0 | 0 / 0 |
| liver | 2% | 9.23 | 4 / 226 | 16% | 1.68 | 64 / 406 |
| heart | 12% | 61.25 | 100 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 11% | 0.82 | 9 / 80 |
| brain | 0% | 2.51 | 11 / 2642 | 4% | 0.38 | 28 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0035435 | Biological process | phosphate ion transmembrane transport |
| GO_0060057 | Biological process | apoptotic process involved in mammary gland involution |
| GO_0046697 | Biological process | decidualization |
| GO_0060745 | Biological process | mammary gland branching involved in pregnancy |
| GO_0070564 | Biological process | positive regulation of vitamin D receptor signaling pathway |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0007275 | Biological process | multicellular organism development |
| GO_0060058 | Biological process | positive regulation of apoptotic process involved in mammary gland involution |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0010980 | Biological process | positive regulation of vitamin D 24-hydroxylase activity |
| GO_0010839 | Biological process | negative regulation of keratinocyte proliferation |
| GO_0038183 | Biological process | bile acid signaling pathway |
| GO_0030154 | Biological process | cell differentiation |
| GO_0050892 | Biological process | intestinal absorption |
| GO_0042789 | Biological process | mRNA transcription by RNA polymerase II |
| GO_0001501 | Biological process | skeletal system development |
| GO_1903412 | Biological process | response to bile acid |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0007595 | Biological process | lactation |
| GO_0070561 | Biological process | vitamin D receptor signaling pathway |
| GO_0060558 | Biological process | regulation of calcidiol 1-monooxygenase activity |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0030501 | Biological process | positive regulation of bone mineralization |
| GO_0045618 | Biological process | positive regulation of keratinocyte differentiation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_0070644 | Molecular function | vitamin D response element binding |
| GO_0046965 | Molecular function | nuclear retinoid X receptor binding |
| GO_0038186 | Molecular function | bile acid nuclear receptor activity |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_1902098 | Molecular function | calcitriol binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_1902121 | Molecular function | lithocholic acid binding |
| Gene name | VDR |
| Protein name | Vitamin D receptor Vitamin D3 receptor (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) |
| Synonyms | NR1I1 |
| Description | FUNCTION: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells . Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR . The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes . Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites . . |
| Accessions | F8VPF8 ENST00000229022.9 T1WSH6 ENST00000548664.1 Q6SZ90 A0A5K1VW50 F8VRJ4 Q6T928 F8VVY8 A0A223ZRY6 A0A224A4N4 ENST00000550325.5 [P11473-2] ENST00000547065.1 T1WSQ6 A0A4P8L6U7 F8VXQ9 ENST00000546653.5 ENST00000550314.5 P11473 ENST00000395324.6 [P11473-1] ENST00000549336.6 [P11473-1] T1WRW3 |
