I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 3 studies | 19% ± 1% | |
| basal cell | 3 studies | 30% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 3 studies | 19% ± 1% | |
| basal cell | 3 studies | 30% ± 9% |
Insufficient scRNA-seq data for expression of RARG at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 2595.00 | 180 / 180 | 100% | 61.77 | 430 / 430 |
| uterus | 100% | 4152.68 | 170 / 170 | 100% | 79.43 | 457 / 459 |
| skin | 100% | 11236.66 | 1809 / 1809 | 99% | 42.07 | 467 / 472 |
| thymus | 100% | 3402.90 | 651 / 653 | 96% | 39.04 | 582 / 605 |
| bladder | 100% | 3422.05 | 21 / 21 | 95% | 52.49 | 479 / 504 |
| esophagus | 99% | 7705.47 | 1427 / 1445 | 96% | 52.93 | 176 / 183 |
| breast | 92% | 2771.89 | 422 / 459 | 99% | 43.06 | 1104 / 1118 |
| lung | 95% | 2085.60 | 550 / 578 | 93% | 38.29 | 1079 / 1155 |
| intestine | 89% | 2244.76 | 860 / 966 | 93% | 25.85 | 492 / 527 |
| adrenal gland | 97% | 2042.37 | 250 / 258 | 73% | 12.78 | 168 / 230 |
| stomach | 78% | 1459.26 | 279 / 359 | 89% | 22.38 | 255 / 286 |
| prostate | 100% | 3821.42 | 244 / 245 | 67% | 10.43 | 334 / 502 |
| kidney | 67% | 1171.25 | 60 / 89 | 69% | 12.60 | 618 / 901 |
| pancreas | 20% | 251.09 | 65 / 328 | 96% | 40.54 | 170 / 178 |
| ureter | 0% | 0 | 0 / 0 | 100% | 96.52 | 1 / 1 |
| blood vessel | 99% | 3013.25 | 1316 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 100.18 | 44 / 45 |
| eye | 0% | 0 | 0 / 0 | 94% | 19.09 | 75 / 80 |
| adipose | 87% | 1997.10 | 1048 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 84% | 1213.90 | 202 / 241 | 0% | 0 | 0 / 0 |
| brain | 32% | 487.76 | 835 / 2642 | 39% | 4.89 | 273 / 705 |
| heart | 64% | 1072.96 | 549 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 2.22 | 6 / 29 |
| liver | 1% | 16.14 | 3 / 226 | 15% | 3.29 | 61 / 406 |
| peripheral blood | 8% | 95.10 | 73 / 929 | 0% | 0 | 0 / 0 |
| muscle | 6% | 71.62 | 50 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071300 | Biological process | cellular response to retinoic acid |
| GO_0031641 | Biological process | regulation of myelination |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0003430 | Biological process | growth plate cartilage chondrocyte growth |
| GO_0045637 | Biological process | regulation of myeloid cell differentiation |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_0060534 | Biological process | trachea cartilage development |
| GO_0072089 | Biological process | stem cell proliferation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0002068 | Biological process | glandular epithelial cell development |
| GO_0035116 | Biological process | embryonic hindlimb morphogenesis |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0032331 | Biological process | negative regulation of chondrocyte differentiation |
| GO_2000647 | Biological process | negative regulation of stem cell proliferation |
| GO_0043068 | Biological process | positive regulation of programmed cell death |
| GO_0060324 | Biological process | face development |
| GO_0030154 | Biological process | cell differentiation |
| GO_0060740 | Biological process | prostate gland epithelium morphogenesis |
| GO_0001843 | Biological process | neural tube closure |
| GO_0031076 | Biological process | embryonic camera-type eye development |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0009755 | Biological process | hormone-mediated signaling pathway |
| GO_0070384 | Biological process | Harderian gland development |
| GO_0006915 | Biological process | apoptotic process |
| GO_0032526 | Biological process | response to retinoic acid |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0008361 | Biological process | regulation of cell size |
| GO_0048384 | Biological process | retinoic acid receptor signaling pathway |
| GO_0048048 | Biological process | embryonic eye morphogenesis |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0016020 | Cellular component | membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0046965 | Molecular function | nuclear retinoid X receptor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RARG |
| Protein name | Retinoic acid receptor gamma Retinoic acid nuclear receptor gamma variant 1 (Retinoic acid receptor gamma) (Retinoic acid receptor, gamma, isoform CRA_b) (cDNA FLJ75202, highly similar to Homo sapiens, retinoic acid receptor, gamma) Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) |
| Synonyms | hCG_31521 NR1B3 |
| Description | FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). . |
| Accessions | H3BMK1 P13631 Q9BZI0 ENST00000543726.1 [P13631-4] ENST00000394426.5 [P13631-3] ENST00000546717.1 H3BMY6 ENST00000551158.5 A8K3H3 H3BMH6 ENST00000550362.5 ENST00000425354.7 [P13631-1] ENST00000338561.9 [P13631-2] |
