NR3C1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043402Biological processglucocorticoid mediated signaling pathway
GO_0006325Biological processchromatin organization
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0007059Biological processchromosome segregation
GO_0030518Biological processnuclear receptor-mediated steroid hormone signaling pathway
GO_0061744Biological processmotor behavior
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0071383Biological processcellular response to steroid hormone stimulus
GO_0051301Biological processcell division
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0008211Biological processglucocorticoid metabolic process
GO_0060603Biological processmammary gland duct morphogenesis
GO_0048708Biological processastrocyte differentiation
GO_0006111Biological processregulation of gluconeogenesis
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0042921Biological processnuclear receptor-mediated glucocorticoid signaling pathway
GO_0042711Biological processmaternal behavior
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0014004Biological processmicroglia differentiation
GO_0030325Biological processadrenal gland development
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0031946Biological processregulation of glucocorticoid biosynthetic process
GO_0006915Biological processapoptotic process
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_0010467Biological processgene expression
GO_0150076Biological processneuroinflammatory response
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0017025Molecular functionTBP-class protein binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0051879Molecular functionHsp90 protein binding
GO_0004879Molecular functionnuclear receptor activity
GO_0004883Molecular functionnuclear glucocorticoid receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0034056Molecular functionestrogen response element binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0005496Molecular functionsteroid binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_1990239Molecular functionsteroid hormone binding

IV. Literature review

[source]
Gene nameNR3C1
Protein nameGlucocorticoid receptor (Nuclear receptor subfamily 3 group C member 1)
Nuclear receptor subfamily 3 group C member 1 variant hGR-B(54)
Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
Alternative protein NR3C1
Nuclear receptor subfamily 3 group C member 1
Nuclear receptor subfamily 3 group C member 1 (Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor))
Nuclear receptor subfamily 3 group C member 1 variant hGR-B(93)
Glucocorticoid receptor
Nuclear receptor subfamily 3 group C member 1 variant hGR-B(77)
Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
SynonymsGCR
GRL
hCG_37601
GR
DescriptionFUNCTION: Receptor for glucocorticoids (GC) . Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors . Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling . Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). .; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity . Mediates glucocorticoid-induced apoptosis . Promotes accurate chromosome segregation during mitosis . May act as a tumor suppressor . May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). .; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha . Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed . Loses this transcription modulator function on its own . Has no hormone-binding activity . May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner . Directly regulates STAT1 expression in isoform Alpha-independent manner . .; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism .; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. .; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. .; FUNCTION: [Isoform 10]: Has transcriptional activation activity. .; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. .; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. .; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation . Has transcriptional repression activity . Mediates glucocorticoid-induced apoptosis . .; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. .; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. .; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation . Has transcriptional repression activity . .

AccessionsENST00000504572.5 [P04150-3]
E5KQF6
ENST00000502892.5
ENST00000502500.1
ENST00000394466.6 [P04150-3]
L8E9L6
ENST00000343796.6 [P04150-1]
H6V744
Q3MSN1
A0A5B9RIM3
ENST00000508760.5
F5ATB8
A0A494C0P1
ENST00000652686.1
ENST00000424646.6 [P04150-10]
B6ZGU6
D6RDA9
E5KQF5
F1D8N4
ENST00000394464.7 [P04150-1]
Q3MSN4
H6V745
ENST00000415690.6 [P04150-2]
P04150
A0A411AGW6
A0A411AGV9
A0A411AGV5
ENST00000503201.1 [P04150-1]
ENST00000514699.1
ENST00000231509.7 [P04150-3]
ENST00000510170.5