synapse

I. Involved cell-cell interactions

[source]
Interactors
Protein name
Directionality
Classification
1CHAT-CHRM1 - ACM1_HUMANLigand-ReceptorSignaling by Acetylcholine
2CHAT-CHRM2 - ACM2_HUMANLigand-ReceptorSignaling by Acetylcholine
3CHAT-CHRM3 - ACM3_HUMANLigand-ReceptorSignaling by Acetylcholine
4CHAT-CHRM4 - ACM4_HUMANLigand-ReceptorSignaling by Acetylcholine
5CHAT-CHRM5 - ACM5_HUMANLigand-ReceptorSignaling by Acetylcholine
6CHAT-CHRNA1 - ACHA_HUMANLigand-ReceptorSignaling by Acetylcholine
7CHAT-CHRNA2+CHRNB3 - Ligand-ReceptorSignaling by Acetylcholine
8CHAT-CHRNA3+CHRNA5+CHRNB2 - Ligand-ReceptorSignaling by Acetylcholine
9CHAT-CHRNA3+CHRNA5+CHRNB4 - Ligand-ReceptorSignaling by Acetylcholine
10CHAT-CHRNA4+CHRNA6+CHRNB3 - Ligand-ReceptorSignaling by Acetylcholine
11CHAT-CHRNA4+CHRNB2 - Ligand-ReceptorSignaling by Acetylcholine
12CHAT-CHRNA6+CHRNB3+CHRNB4 - Ligand-ReceptorSignaling by Acetylcholine
13CHAT-CHRNA7 - ACHA7_HUMANLigand-ReceptorSignaling by Acetylcholine
14CHAT+SLC10A4-CHRM1 - ACM1_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
15CHAT+SLC10A4-CHRM2 - ACM2_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
16CHAT+SLC10A4-CHRM3 - ACM3_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
17CHAT+SLC10A4-CHRM4 - ACM4_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
18CHAT+SLC10A4-CHRM5 - ACM5_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
19CHAT+SLC10A4-CHRNA1+CHRNB1+CHRND+CHRNE - Ligand-ReceptorSignaling by Choline acetyltransferase
20CHAT+SLC10A4-CHRNA1+CHRNB1+CHRND+CHRNG - Ligand-ReceptorSignaling by Choline acetyltransferase
21CHAT+SLC10A4-CHRNA3+CHRNB4 - Ligand-ReceptorSignaling by Choline acetyltransferase
22CHAT+SLC10A4-CHRNA4+CHRNB2 - Ligand-ReceptorSignaling by Choline acetyltransferase
23CHAT+SLC10A4-CHRNA7 - Ligand-ReceptorSignaling by Choline acetyltransferase
24CHAT+SLC18A3-CHRM1 - ACM1_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
25CHAT+SLC18A3-CHRM2 - ACM2_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
26CHAT+SLC18A3-CHRM3 - ACM3_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
27CHAT+SLC18A3-CHRM4 - ACM4_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
28CHAT+SLC18A3-CHRM5 - ACM5_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
29CHAT+SLC18A3-CHRNA1+CHRNB1+CHRND+CHRNE - Ligand-ReceptorSignaling by Choline acetyltransferase
30CHAT+SLC18A3-CHRNA1+CHRNB1+CHRND+CHRNG - Ligand-ReceptorSignaling by Choline acetyltransferase
31CHAT+SLC18A3-CHRNA3+CHRNB4 - Ligand-ReceptorSignaling by Choline acetyltransferase
32CHAT+SLC18A3-CHRNA4+CHRNB2 - Ligand-ReceptorSignaling by Choline acetyltransferase
33CHAT+SLC18A3-CHRNA7 - Ligand-ReceptorSignaling by Choline acetyltransferase
34CHAT+SLC5A7-CHRM1 - ACM1_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
35CHAT+SLC5A7-CHRM2 - ACM2_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
36CHAT+SLC5A7-CHRM3 - ACM3_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
37CHAT+SLC5A7-CHRM4 - ACM4_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
38CHAT+SLC5A7-CHRM5 - ACM5_HUMANLigand-ReceptorSignaling by Choline acetyltransferase
39CHAT+SLC5A7-CHRNA1+CHRNB1+CHRND+CHRNE - Ligand-ReceptorSignaling by Choline acetyltransferase
40CHAT+SLC5A7-CHRNA1+CHRNB1+CHRND+CHRNG - Ligand-ReceptorSignaling by Choline acetyltransferase
41CHAT+SLC5A7-CHRNA3+CHRNB4 - Ligand-ReceptorSignaling by Choline acetyltransferase
42CHAT+SLC5A7-CHRNA4+CHRNB2 - Ligand-ReceptorSignaling by Choline acetyltransferase
43CHAT+SLC5A7-CHRNA7 - Ligand-ReceptorSignaling by Choline acetyltransferase
44FGA+FGB+FGG-ITGA2B+ITGB3 - Ligand-ReceptorAdhesion by Fibribogen
45FLRT1+TENM2-ADGRL1 - AGRL1_HUMANLigand-ReceptorSignaling by Fibronectin
46FLRT2-ADGRL1FLRT2_HUMAN - AGRL1_HUMANLigand-ReceptorSignaling by Fibronectin
47FLRT3+TENM2-ADGRL1 - AGRL1_HUMANLigand-ReceptorSignaling by Fibronectin
48GLS2+SLC1A3-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
49GLS2+SLC1A3-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
50GLS2+SLC1A3-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
51GLS2+SLC1A3-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
52GLS2+SLC1A3-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
53GLS+SLC17A6-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
54GLS+SLC17A6-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
55GLS+SLC17A6-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
56GLS+SLC17A6-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
57GLS+SLC17A6-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
58GLS+SLC17A7-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
59GLS+SLC17A7-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
60GLS+SLC17A7-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
61GLS+SLC17A7-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
62GLS+SLC17A7-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
63GLS+SLC17A8-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
64GLS+SLC17A8-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
65GLS+SLC17A8-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
66GLS+SLC17A8-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
67GLS+SLC17A8-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
68GLS+SLC1A1-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
69GLS+SLC1A1-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
70GLS+SLC1A1-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
71GLS+SLC1A1-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
72GLS+SLC1A1-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
73GLS+SLC1A2-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
74GLS+SLC1A2-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
75GLS+SLC1A2-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
76GLS+SLC1A2-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
77GLS+SLC1A2-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
78GLS+SLC1A3-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
79GLS+SLC1A3-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
80GLS+SLC1A3-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
81GLS+SLC1A3-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
82GLS+SLC1A3-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
83GLS+SLC1A6-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
84GLS+SLC1A6-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
85GLS+SLC1A6-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
86GLS+SLC1A6-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
87GLS+SLC1A6-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
88GLS+SLC1A7-GRIN1+GRIN2A - Ligand-ReceptorSignaling by Glutamate
89GLS+SLC1A7-GRIN1+GRIN2B - Ligand-ReceptorSignaling by Glutamate
90GLS+SLC1A7-GRIN1+GRIN2C - Ligand-ReceptorSignaling by Glutamate
91GLS+SLC1A7-GRIN1+GRIN2D - Ligand-ReceptorSignaling by Glutamate
92GLS+SLC1A7-GRM6 - GRM6_HUMANLigand-ReceptorSignaling by Glutamate
93SLC6A4+TPH1-HTR1A - 5HT1A_HUMANLigand-ReceptorSignaling by Serotonin
94SLC6A4+TPH1-HTR1D - 5HT1D_HUMANLigand-ReceptorSignaling by Serotonin
95SLC6A4+TPH1-HTR1E - 5HT1E_HUMANLigand-ReceptorSignaling by Serotonin
96SLC6A4+TPH1-HTR1F - 5HT1F_HUMANLigand-ReceptorSignaling by Serotonin
97SLC6A4+TPH1-HTR2B - 5HT2B_HUMANLigand-ReceptorSignaling by Serotonin
98SLC6A4+TPH1-HTR2C - 5HT2C_HUMANLigand-ReceptorSignaling by Serotonin
99SLC6A4+TPH1-HTR3A+HTR3B+HTR3C+HTR3D+HTR3E - Ligand-ReceptorSignaling by Serotonin
100SLC6A4+TPH1-HTR4 - 5HT4R_HUMANLigand-ReceptorSignaling by Serotonin
101SLC6A4+TPH1-HTR6 - 5HT6R_HUMANLigand-ReceptorSignaling by Serotonin
102SLC6A4+TPH1-HTR7 - 5HT7R_HUMANLigand-ReceptorSignaling by Serotonin
103SLC6A4+TPH2-HTR1A - 5HT1A_HUMANLigand-ReceptorSignaling by Serotonin
104SLC6A4+TPH2-HTR1D - 5HT1D_HUMANLigand-ReceptorSignaling by Serotonin
105SLC6A4+TPH2-HTR1E - 5HT1E_HUMANLigand-ReceptorSignaling by Serotonin
106SLC6A4+TPH2-HTR1F - 5HT1F_HUMANLigand-ReceptorSignaling by Serotonin
107SLC6A4+TPH2-HTR2B - 5HT2B_HUMANLigand-ReceptorSignaling by Serotonin
108SLC6A4+TPH2-HTR2C - 5HT2C_HUMANLigand-ReceptorSignaling by Serotonin
109SLC6A4+TPH2-HTR3A+HTR3B+HTR3C+HTR3D+HTR3E - Ligand-ReceptorSignaling by Serotonin
110SLC6A4+TPH2-HTR4 - 5HT4R_HUMANLigand-ReceptorSignaling by Serotonin
111SLC6A4+TPH2-HTR6 - 5HT6R_HUMANLigand-ReceptorSignaling by Serotonin
112SLC6A4+TPH2-HTR7 - 5HT7R_HUMANLigand-ReceptorSignaling by Serotonin
113TENM2-ADGRL1TEN2_HUMAN - AGRL1_HUMANLigand-ReceptorSignaling by Teneurin

II. Literature review

[source]
Namesynapse
IDGO_0045202
collection_id

Cellular component

Exact synonym

synaptic junction

Description

The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

Related synonym

electrotonic synapse

External URL
Genes
PLAATTYH1RPL15SYT11GRIN1RPS5DACT1GABRR3CHRNA5CORTRPL34GNAI2PCDHB5HTR3EGLRA1PCDHB4RPL13HTR1AYBX3DSCAML1NSMFALDH5A1MPSTMAPK8SLC8A1ZMYND19ADGRL1RPS7VAMP3MMETIAM1CPEB1SYT4SAMD4AAPBB2TPGS1CNIH3DNM1RPL27PHACTR1GNAQCACNA1ELRP8ARFGAP1DGKIHCRTR2CHRNA3MYO9ADOC2AGNA11C22orf39CYFIP1KCNMB1NLGN3SYT7NDFIP1GABRA1YWHAQPTPRZ1RAPGEF2TULP1MAP1BCALB2RPL23BCANPOTEJFLRT2PCDHB14PTPRCSORBS2SCN2BC1QBDPYSL3RPS16gabar_a6_b3_delta_humanACHESLC8A2ARR3NOS1LYPD1COMTLIN7CPOTEFRPS23GABRB3HNRNPFSLC12A7DNM3DBHEIF3BRPS6KA4RPH3ALVWC2CAPN5CHRNDKCNK3TDRD1PACSIN1FABP5RPS28ADORA1gabar_a1_b2_g2_humanHRH2TMOD2CORO1CPSMA3MAGI2LYPD6GNA15MYLK2PCLOgabar_a1_b3_g2_humanVCANMAPK1RPL7ARPL19HNRNPLLHAPLN2SYN2LIN7BCRHHTR2CMAP1AATP1A3MYCBPAPHCRTR1C4BDOK7CAMK2N2USP14GPC4SLC12A6ANXA9GABRR1APPGABRQDTNAADARB1EIF2S1ATXN3MBPNLGN2CNTN4FAM107ACSPG5TENM2PCDHB16CLUGLSGABRPCNTN6CNIH2MRPL55PRIMA1VWC2LSLC1A3EXT1EIF5KIF1ACYFIP2SNTB2CHRNA6PDZD11POTEELZTS3TUFMRPS6KA3GPC2CALB1RPS9CHRFAM7AHTR4GABRB1ACTG1MACO1GLRBdgc_human-1RIC3RPL28GPR176GABRA3FRRS1LITGB3DSCAMCADM1ACTBCPEB3SNAPINGABRG1RTN4SLC1A4HTR1DPCDHB3USH1CGPR37UNC5CCHRM5PTPRNHTR3APOTEIEFNB1RPS15APLP1UBA52PPP2CAYBX1PMCHL2EGR3HAPLN1OLFM1RGS8TIAM2RPS17PMCHgabar_a4_b2_delta_humanPVALBC1QCEIF5BCHRNGDRD5DNMBPCACNB1RASD2CHN2HTR3BCHRM1HTR3DCD53SLC8A3GDI2DMDKCNQ2SLC12A4CARTPTCHRM3GABRA6ALDH1A1RGS10CHRNA4SCGNPCDHB9RPS27AHTR2BGABRR2VDAC3SLITRK1PCDHB10EIF3FCHRNB2GABRA5SSH1MYO7APICK1OLFM3CHRM2RPH3ACEP89MPZGABRB2ARL8BCHRNEEMBDLG4EIF3IPSMC4C1QASTAC3OLFM2PMP22NMNAT2RGS17SHISA9APBB1NPBWR1SLC4A10HNRNPA0HTR1FMTNR1BNCANLRP6KCNIP2EIF3Labeta-42-oligomer_humanCNPQKISLC3A2PCDHB6RPS15SLC6A7PLCXD3FZD5C4ACACNB3PAK5gabar_a4_b3_delta_humanSLC12A5STX4RPS4XVAMP2KCNMB4GLRA3RPL24LIN7ACHRNB4HNRNPMDVL1MAP1SNPR2ACTL9GABRDGRID2PGRMC1GNAT2SDK1CHATARL8AHTR7CHRNA7TLN2RPL36AGRNCHRM4SRCIN1GIT1PCDH15AKR1A1gabar_a1_b1_g2_humanTSC22D4SARM1RAB21HNRNPUL1EIF6CHRNA1GNB1RPS11LY6HTDRD5ERC1KCNN1RPS6KA1VDAC1DYTNHNRNPUL2BEGAINMYRIPCHRNA10GPC6PMCHL1PURGRASGRP2OMPENAHHTR1EDRD3CACNA1GTRAPPC4KCNQ3GJC1CPEB4SHARPINVPS54RPS26GABRG2CHRNA2CHRNA9WHRNDOC2BHRH3VAMP7PRKCEGABRG3GJD2NRN1KIF5AEEF2RANBP6DARS1KCNAB2CAMK2N1NDE1RPS3ACHRNB1WASF2KCMF1EZH2MAPK8IP1PPA2HRH1ATCAYHTR3CLYNX1SPARTPCDHB2GLRA2FGF12RIMBP2CAPRIN1GPC1UTS2LY6G6DCHRDL1HAPLN3RPS20DNM2POTEKPSDK2RPS21RPL21CAMK2BSLC16A1CADM2PPFIA4RGS12NLGN1SNTB1ADORA3KCNC2CBLN4CPEB2PTCHD1APOA4PCDHB11PDE7BCNTN2ITGB1SH3KBP1SLC9A5SLITRK5FMR1UNC119KCNA1LY6G6ECHRNB3SLURP2SLC38A6NLGN4XPTPRN2GABARAPHTR6SLC6A4GRM6CACNA1BSPG11LPAR3GABRA4DTNBRPL26CABP4TAC1ACANRELBCBLN2RPS6KA2RIT2FBXO45gabbr_r1_r2_humanGIT2EIF3DHAPLN4CACNA1AEEF1A2GABRA2SYAP1HRH4GABRESLC5A7GALR3NPSNQO1CTNNB1OPRM1RPL13ANLGN4YCBLN3GRIN3AEXOC4FGBCTBP2EIF2S2NR3C1