DRD3 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DRD3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	25%	36.54	666 / 2642	1%	0.09	7 / 705
spleen	3%	0.24	7 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.06	1 / 45
esophagus	0%	0.03	4 / 1445	1%	0.01	1 / 183
intestine	1%	0.07	6 / 966	0%	0.00	1 / 527
breast	1%	0.07	3 / 459	0%	0.00	1 / 1118
peripheral blood	1%	0.07	6 / 929	0%	0	0 / 0
stomach	0%	0.02	1 / 359	0%	0.00	1 / 286
lung	0%	0.07	1 / 578	0%	0.01	4 / 1155
thymus	0%	0.06	3 / 653	0%	0	0 / 605
adrenal gland	0%	0	0 / 258	0%	0.01	1 / 230
prostate	0%	0.03	1 / 245	0%	0	0 / 502
muscle	0%	0.03	2 / 803	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0.00	1 / 430
uterus	0%	0	0 / 170	0%	0.00	1 / 459
skin	0%	0.02	3 / 1809	0%	0	0 / 472
blood vessel	0%	0.02	2 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
bladder	0%	0	0 / 21	0%	0	0 / 504
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
kidney	0%	0	0 / 89	0%	0	0 / 901
liver	0%	0	0 / 226	0%	0	0 / 406
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
pancreas	0%	0	0 / 328	0%	0	0 / 178
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0014059	Biological process	regulation of dopamine secretion
GO_0007194	Biological process	negative regulation of adenylate cyclase activity
GO_0034776	Biological process	response to histamine
GO_0048715	Biological process	negative regulation of oligodendrocyte differentiation
GO_0060161	Biological process	positive regulation of dopamine receptor signaling pathway
GO_0007195	Biological process	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO_0043278	Biological process	response to morphine
GO_0071880	Biological process	adenylate cyclase-activating adrenergic receptor signaling pathway
GO_0007612	Biological process	learning
GO_0007611	Biological process	learning or memory
GO_0051584	Biological process	regulation of dopamine uptake involved in synaptic transmission
GO_0007191	Biological process	adenylate cyclase-activating dopamine receptor signaling pathway
GO_1901386	Biological process	negative regulation of voltage-gated calcium channel activity
GO_0042417	Biological process	dopamine metabolic process
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0043266	Biological process	regulation of potassium ion transport
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0051967	Biological process	negative regulation of synaptic transmission, glutamatergic
GO_0060158	Biological process	phospholipase C-activating dopamine receptor signaling pathway
GO_0045471	Biological process	response to ethanol
GO_0050709	Biological process	negative regulation of protein secretion
GO_0032922	Biological process	circadian regulation of gene expression
GO_0008542	Biological process	visual learning
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0042220	Biological process	response to cocaine
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0045776	Biological process	negative regulation of blood pressure
GO_0046717	Biological process	acid secretion
GO_0002031	Biological process	G protein-coupled receptor internalization
GO_0001963	Biological process	synaptic transmission, dopaminergic
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0048148	Biological process	behavioral response to cocaine
GO_0060134	Biological process	prepulse inhibition
GO_0035176	Biological process	social behavior
GO_0032467	Biological process	positive regulation of cytokinesis
GO_0007626	Biological process	locomotory behavior
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0051481	Biological process	negative regulation of cytosolic calcium ion concentration
GO_0050883	Biological process	musculoskeletal movement, spinal reflex action
GO_0050482	Biological process	arachidonic acid secretion
GO_0005886	Cellular component	plasma membrane
GO_0045202	Cellular component	synapse
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0001591	Molecular function	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DRD3
Protein name	D(3) dopamine receptor (Dopamine D3 receptor) Dopamine receptor D3 isoform B Dopamine D3 receptor
Synonyms
Description	FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. . FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. . FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. . FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. . FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. . FUNCTION: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. .
Accessions	E9PCM4 ENST00000383673.5 [P35462-1] ENST00000698213.1 Q13167 ENST00000467632.5 [P35462-1] ENST00000295881.9 [P35462-3] ENST00000295881 P35462 X5D2G4 A0A8V8TLH3 Q9BXX6 Q9NY31 X5DP70 A1A4V4 ENST00000460779.5 [P35462-1]

DRD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review