OPRM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0007218Biological processneuropeptide signaling pathway
GO_0007197Biological processadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0048149Biological processbehavioral response to ethanol
GO_2000310Biological processregulation of NMDA receptor activity
GO_0050769Biological processpositive regulation of neurogenesis
GO_0071315Biological processcellular response to morphine
GO_0007600Biological processsensory perception
GO_0061358Biological processnegative regulation of Wnt protein secretion
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0080135Biological processregulation of cellular response to stress
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0038003Biological processG protein-coupled opioid receptor signaling pathway
GO_0070588Biological processcalcium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_0005794Cellular componentGolgi apparatus
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0005783Cellular componentendoplasmic reticulum
GO_0045202Cellular componentsynapse
GO_0030424Cellular componentaxon
GO_0005768Cellular componentendosome
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0031681Molecular functionG-protein beta-subunit binding
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0042923Molecular functionneuropeptide binding
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0038047Molecular functionmorphine receptor activity
GO_0005515Molecular functionprotein binding
GO_0004979Molecular functionbeta-endorphin receptor activity

IV. Literature review

[source]
Gene nameOPRM1
Protein nameMu opioid receptor
Mu opioid receptor MOR-1O
Opioid receptor mu 1
Opioid receptor mu
Mu opioid receptor splice variant hMOR-1S
Mu-type opioid receptor
Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP)
Mu opioid receptor splice variant MOR-1H
Mutant opioid receptor mu
SynonymsMOR1
OPRM
MOP
MOR
DescriptionFUNCTION: Receptor for endogenous opioids such as beta-endorphin and endomorphin . Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone . Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors . The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 . They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). .; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. .; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. .; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. .

AccessionsA0A0F6TMB4
B7SXT1
ENST00000337049.8 [P35372-5]
ENST00000522739.5 [P35372-6]
ENST00000518759.5 [P35372-13]
A0A6H0WCP3
B8K2Q5
ENST00000330432.12 [P35372-1]
ENST00000435918.6 [P35372-8]
A0A0F6TN24
ENST00000229768.9 [P35372-3]
ENST00000519083.5 [P35372-6]
ENST00000434900.6 [P35372-10]
ENST00000522555.5 [P35372-12]
G8XRH5
A0A0F6RA07
O43185
Q71V90
ENST00000414028.6 [P35372-4]
Q716A7
A0A0F6TMM4
ENST00000360422.8
B7SXT4
ENST00000428397.6 [P35372-2]
P35372
ENST00000524150.2 [P35372-18]
E7EW71
ENST00000522236.1 [P35372-12]
B7SXT0
A0A6H0WF09
ENST00000452687.6 [P35372-7]
C9EA00
L0E130
A0A089PQW6
B7SXT3
C7E9I8
ENST00000524163.5 [P35372-11]
C9E9Z9
G8XRH4
ENST00000419506.6 [P35372-9]
B7SXT2
ENST00000520708.5 [P35372-12]
A0A0F6RAI2
ENST00000520282.5
A0A0F6TMT4