EIF5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	40% ± 17%	Explore
B cell	39 studies	42% ± 13%	Explore
fibroblast	39 studies	42% ± 18%	Explore
natural killer cell	36 studies	41% ± 12%	Explore
macrophage	34 studies	42% ± 14%	Explore
CD8-positive, alpha-beta T cell	32 studies	40% ± 11%	Explore
T cell	31 studies	37% ± 15%	Explore
CD4-positive, alpha-beta T cell	31 studies	40% ± 13%	Explore
pericyte	30 studies	39% ± 17%	Explore
conventional dendritic cell	28 studies	44% ± 16%	Explore
smooth muscle cell	26 studies	41% ± 15%	Explore
classical monocyte	24 studies	43% ± 14%	Explore
regulatory T cell	24 studies	42% ± 12%	Explore
mast cell	23 studies	43% ± 16%	Explore
plasma cell	23 studies	40% ± 14%	Explore
non-classical monocyte	23 studies	45% ± 16%	Explore
dendritic cell	22 studies	47% ± 20%	Explore
monocyte	21 studies	37% ± 14%	Explore
plasmacytoid dendritic cell	21 studies	52% ± 14%	Explore
basal cell	21 studies	44% ± 12%	Explore
memory B cell	20 studies	45% ± 11%	Explore
endothelial cell of lymphatic vessel	19 studies	38% ± 14%	Explore
mature NK T cell	19 studies	35% ± 11%	Explore
epithelial cell	19 studies	44% ± 19%	Explore
naive B cell	19 studies	39% ± 13%	Explore
ciliated cell	17 studies	52% ± 16%	Explore
gamma-delta T cell	17 studies	43% ± 18%	Explore
connective tissue cell	16 studies	43% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	35% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	40% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	39% ± 11%	Explore
myeloid cell	14 studies	43% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	37% ± 12%	Explore
capillary endothelial cell	13 studies	34% ± 13%	Explore
myofibroblast cell	13 studies	42% ± 13%	Explore
astrocyte	13 studies	32% ± 11%	Explore
mucosal invariant T cell	13 studies	40% ± 13%	Explore
endothelial cell of vascular tree	13 studies	43% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	41% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	42% ± 13%	Explore
vein endothelial cell	12 studies	36% ± 13%	Explore
plasmablast	11 studies	56% ± 17%	Explore
secretory cell	11 studies	38% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	40% ± 16%	Explore
oligodendrocyte	10 studies	27% ± 10%	Explore
endothelial cell of artery	10 studies	35% ± 12%	Explore
glutamatergic neuron	10 studies	33% ± 20%	Explore
erythrocyte	10 studies	41% ± 18%	Explore
type II pneumocyte	9 studies	32% ± 14%	Explore
leukocyte	9 studies	46% ± 15%	Explore
progenitor cell	9 studies	40% ± 13%	Explore
abnormal cell	9 studies	46% ± 11%	Explore
goblet cell	9 studies	30% ± 12%	Explore
mesothelial cell	9 studies	32% ± 15%	Explore
IgG plasma cell	9 studies	32% ± 10%	Explore
type I pneumocyte	8 studies	37% ± 16%	Explore
club cell	8 studies	34% ± 10%	Explore
platelet	8 studies	22% ± 4%	Explore
neuron	8 studies	38% ± 17%	Explore
microglial cell	8 studies	30% ± 18%	Explore
alveolar macrophage	7 studies	39% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	42% ± 7%	Explore
epithelial cell of proximal tubule	7 studies	29% ± 7%	Explore
IgA plasma cell	7 studies	32% ± 13%	Explore
innate lymphoid cell	7 studies	48% ± 11%	Explore
T follicular helper cell	7 studies	44% ± 12%	Explore
oligodendrocyte precursor cell	7 studies	33% ± 10%	Explore
ionocyte	6 studies	46% ± 7%	Explore
respiratory goblet cell	6 studies	38% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	44% ± 10%	Explore
mononuclear phagocyte	6 studies	44% ± 17%	Explore
kidney loop of Henle epithelial cell	6 studies	35% ± 8%	Explore
enterocyte	6 studies	29% ± 7%	Explore
transit amplifying cell	6 studies	27% ± 8%	Explore
hematopoietic stem cell	6 studies	33% ± 13%	Explore
precursor B cell	6 studies	49% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	46% ± 18%	Explore
GABAergic neuron	6 studies	34% ± 13%	Explore
interneuron	6 studies	32% ± 16%	Explore
hematopoietic precursor cell	5 studies	48% ± 18%	Explore
exhausted T cell	5 studies	41% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	47% ± 7%	Explore
renal alpha-intercalated cell	5 studies	40% ± 13%	Explore
enteroendocrine cell	5 studies	40% ± 14%	Explore
amacrine cell	5 studies	47% ± 19%	Explore
retinal rod cell	5 studies	33% ± 11%	Explore
erythroblast	5 studies	34% ± 25%	Explore
pro-B cell	5 studies	40% ± 12%	Explore
brush cell	5 studies	49% ± 13%	Explore
glial cell	5 studies	34% ± 19%	Explore
hepatocyte	5 studies	48% ± 30%	Explore
deuterosomal cell	4 studies	46% ± 4%	Explore
pancreatic A cell	4 studies	64% ± 5%	Explore
type B pancreatic cell	4 studies	57% ± 21%	Explore
glomerular endothelial cell	4 studies	41% ± 12%	Explore
intestinal crypt stem cell	4 studies	32% ± 9%	Explore
retinal ganglion cell	4 studies	75% ± 17%	Explore
lymphocyte	4 studies	47% ± 19%	Explore
neutrophil	4 studies	22% ± 6%	Explore
immature B cell	4 studies	47% ± 5%	Explore
retina horizontal cell	4 studies	41% ± 19%	Explore
retinal cone cell	4 studies	39% ± 17%	Explore
retinal pigment epithelial cell	4 studies	44% ± 15%	Explore
adventitial cell	4 studies	41% ± 12%	Explore
adipocyte	4 studies	21% ± 5%	Explore
intermediate monocyte	4 studies	54% ± 22%	Explore
CD4-positive helper T cell	4 studies	44% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	59% ± 7%	Explore
granulocyte	4 studies	44% ± 5%	Explore
T-helper 17 cell	4 studies	42% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 5%	Explore
duct epithelial cell	3 studies	28% ± 7%	Explore
precursor cell	3 studies	56% ± 17%	Explore
squamous epithelial cell	3 studies	55% ± 15%	Explore
pancreatic D cell	3 studies	55% ± 12%	Explore
monocyte-derived dendritic cell	3 studies	47% ± 15%	Explore
neural crest cell	3 studies	39% ± 6%	Explore
retinal bipolar neuron	3 studies	44% ± 7%	Explore
renal principal cell	3 studies	45% ± 20%	Explore
extravillous trophoblast	3 studies	51% ± 15%	Explore
placental villous trophoblast	3 studies	70% ± 10%	Explore
neuroendocrine cell	3 studies	41% ± 15%	Explore
mucus secreting cell	3 studies	22% ± 2%	Explore
serous secreting cell	3 studies	26% ± 8%	Explore
tissue-resident macrophage	3 studies	45% ± 24%	Explore
intraepithelial lymphocyte	3 studies	40% ± 19%	Explore
Mueller cell	3 studies	42% ± 4%	Explore
inflammatory macrophage	3 studies	35% ± 27%	Explore
acinar cell	3 studies	39% ± 12%	Explore
endothelial cell of sinusoid	3 studies	16% ± 1%	Explore
germinal center B cell	3 studies	41% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	28% ± 6%	Explore
IgM plasma cell	3 studies	37% ± 8%	Explore
muscle cell	3 studies	38% ± 14%	Explore
pancreatic ductal cell	3 studies	71% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	63% ± 13%	Explore
melanocyte	3 studies	41% ± 17%	Explore
keratinocyte	3 studies	45% ± 13%	Explore
T-helper 1 cell	3 studies	47% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	28% ± 6%	Explore
double negative thymocyte	3 studies	54% ± 18%	Explore
double-positive, alpha-beta thymocyte	3 studies	57% ± 15%	Explore
progenitor cell of mammary luminal epithelium	3 studies	51% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	43% ± 13%	Explore
peripheral blood	17 studies	41% ± 14%	Explore
brain	14 studies	33% ± 14%	Explore
intestine	11 studies	36% ± 14%	Explore
kidney	9 studies	34% ± 11%	Explore
eye	9 studies	38% ± 17%	Explore
liver	7 studies	40% ± 21%	Explore
bone marrow	5 studies	30% ± 11%	Explore
uterus	5 studies	46% ± 18%	Explore
lymph node	5 studies	45% ± 9%	Explore
pancreas	4 studies	59% ± 14%	Explore
adipose	4 studies	23% ± 10%	Explore
prostate	4 studies	35% ± 10%	Explore
breast	4 studies	55% ± 7%	Explore
placenta	3 studies	55% ± 7%	Explore
heart	3 studies	18% ± 1%	Explore
adrenal gland	3 studies	42% ± 16%	Explore
esophagus	3 studies	43% ± 15%	Explore
skin	3 studies	38% ± 14%	Explore
thymus	3 studies	51% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	11974.11	459 / 459	100%	92.11	1118 / 1118
esophagus	100%	12298.89	1445 / 1445	100%	93.64	183 / 183
ovary	100%	9791.56	180 / 180	100%	56.23	430 / 430
pancreas	100%	7241.15	328 / 328	100%	67.92	178 / 178
brain	100%	12437.58	2641 / 2642	100%	107.89	705 / 705
intestine	100%	14444.23	966 / 966	100%	80.90	526 / 527
prostate	100%	10534.47	245 / 245	100%	63.38	501 / 502
liver	100%	16428.39	226 / 226	100%	59.63	405 / 406
lung	100%	10788.81	576 / 578	100%	86.58	1155 / 1155
stomach	100%	10717.69	359 / 359	100%	76.16	285 / 286
bladder	100%	12539.38	21 / 21	100%	77.60	502 / 504
uterus	100%	10858.02	170 / 170	100%	80.12	457 / 459
thymus	100%	12674.04	653 / 653	99%	75.89	601 / 605
kidney	100%	11812.90	89 / 89	99%	59.51	890 / 901
adrenal gland	100%	13303.30	258 / 258	97%	61.23	222 / 230
skin	100%	10651.57	1807 / 1809	96%	73.93	453 / 472
adipose	100%	12964.18	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	70.17	29 / 29
muscle	100%	14985.26	803 / 803	0%	0	0 / 0
spleen	100%	12191.24	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	79.22	45 / 45
ureter	0%	0	0 / 0	100%	56.24	1 / 1
blood vessel	100%	9558.21	1332 / 1335	0%	0	0 / 0
heart	97%	8070.36	833 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	86%	39.82	69 / 80
peripheral blood	86%	6164.30	798 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001732	Biological process	formation of cytoplasmic translation initiation complex
GO_0006446	Biological process	regulation of translational initiation
GO_0042255	Biological process	ribosome assembly
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003743	Molecular function	translation initiation factor activity
GO_0005525	Molecular function	GTP binding
GO_0045296	Molecular function	cadherin binding
GO_0005092	Molecular function	GDP-dissociation inhibitor activity
GO_0071074	Molecular function	eukaryotic initiation factor eIF2 binding
GO_0005515	Molecular function	protein binding
GO_0005096	Molecular function	GTPase activator activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	EIF5
Protein name	Eukaryotic translation initiation factor 5 Eukaryotic translation initiation factor 5 (eIF-5)
Synonyms
Description	FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon . In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) . During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) . This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC . When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP . Start codon recognition also induces a conformational change of the PIC to a closed state . This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC . Finally, EIF5 stabilizes the PIC in its closed conformation . .
Accessions	H0YK29 ENST00000559532.5 Q6IBU0 Q05DF3 ENST00000558506.1 H0YK11 ENST00000559130.5 P55010 ENST00000216554.8 ENST00000558265.5 H0YN40 Q32Q19 ENST00000561325.5 H0YLZ1 H0YM54 ENST00000558316.5 ENST00000560763.5 ENST00000560338.5 ENST00000392715.6 H0YMJ8

EIF5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review