KCNA1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNA1 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0010644Biological processcell communication by electrical coupling
GO_0050976Biological processdetection of mechanical stimulus involved in sensory perception of touch
GO_0021766Biological processhippocampus development
GO_0042391Biological processregulation of membrane potential
GO_0061564Biological processaxon development
GO_0006937Biological processregulation of muscle contraction
GO_0086011Biological processmembrane repolarization during action potential
GO_0050966Biological processdetection of mechanical stimulus involved in sensory perception of pain
GO_0050905Biological processneuromuscular process
GO_0071805Biological processpotassium ion transmembrane transport
GO_0071286Biological processcellular response to magnesium ion
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0021554Biological processoptic nerve development
GO_0019228Biological processneuronal action potential
GO_0022038Biological processcorpus callosum development
GO_0023041Biological processneuronal signal transduction
GO_0060078Biological processregulation of postsynaptic membrane potential
GO_0001964Biological processstartle response
GO_0010960Biological processmagnesium ion homeostasis
GO_0008104Biological processprotein localization
GO_0021987Biological processcerebral cortex development
GO_0001508Biological processaction potential
GO_0007405Biological processneuroblast proliferation
GO_0016324Cellular componentapical plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0043679Cellular componentaxon terminus
GO_0043025Cellular componentneuronal cell body
GO_0043194Cellular componentaxon initial segment
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0044305Cellular componentcalyx of Held
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0070161Cellular componentanchoring junction
GO_0033270Cellular componentparanode region of axon
GO_0044224Cellular componentjuxtaparanode region of axon
GO_0045211Cellular componentpostsynaptic membrane
GO_0030054Cellular componentcell junction
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_1905030Molecular functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0099508Molecular functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNA1
Protein namePotassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1)
Potassium voltage-gated channel subfamily A member 1
Synonyms
DescriptionFUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney . Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability . Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel . Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels . In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure . In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation . Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses . Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential . .

AccessionsENST00000639306.1
A0A1W2PRI2
Q09470
ENST00000382545.5
ENST00000639680.1
A0A1W2PQM4