KCNC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901381Biological processpositive regulation of potassium ion transmembrane transport
GO_0051260Biological processprotein homooligomerization
GO_0006813Biological processpotassium ion transport
GO_0014075Biological processresponse to amine
GO_0032026Biological processresponse to magnesium ion
GO_0038060Biological processnitric oxide-cGMP-mediated signaling
GO_0099605Biological processregulation of action potential firing rate
GO_0014070Biological processresponse to organic cyclic compound
GO_0045471Biological processresponse to ethanol
GO_0071732Biological processcellular response to nitric oxide
GO_0071805Biological processpotassium ion transmembrane transport
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0021554Biological processoptic nerve development
GO_0021759Biological processglobus pallidus development
GO_0060081Biological processmembrane hyperpolarization
GO_0051291Biological processprotein heterooligomerization
GO_0009642Biological processresponse to light intensity
GO_0071242Biological processcellular response to ammonium ion
GO_0097237Biological processcellular response to toxic substance
GO_0001508Biological processaction potential
GO_1990089Biological processresponse to nerve growth factor
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0043195Cellular componentterminal bouton
GO_0043679Cellular componentaxon terminus
GO_0032809Cellular componentneuronal cell body membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0098982Cellular componentGABA-ergic synapse
GO_0030673Cellular componentaxolemma
GO_0045202Cellular componentsynapse
GO_0045211Cellular componentpostsynaptic membrane
GO_0044297Cellular componentcell body
GO_0030424Cellular componentaxon
GO_0031982Cellular componentvesicle
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0032590Cellular componentdendrite membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_0099508Molecular functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0044325Molecular functiontransmembrane transporter binding

IV. Literature review

[source]
Gene nameKCNC2
Protein namePotassium voltage-gated channel subfamily C member 2 (Shaw-like potassium channel) (Voltage-gated potassium channel Kv3.2)
Potassium voltage-gated channel subfamily C member 2
Synonyms
DescriptionFUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane . Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons . Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity). .

AccessionsENST00000647764.1
ENST00000550433.5 [Q96PR1-2]
ENST00000548513.5 [Q96PR1-3]
ENST00000549446.6 [Q96PR1-1]
A0A3B3ISR9
ENST00000350228.6 [Q96PR1-4]
ENST00000393288.2 [Q96PR1-6]
Q96PR1
ENST00000298972.5 [Q96PR1-3]
ENST00000540018.5 [Q96PR1-5]