CPEB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0032869Biological processcellular response to insulin stimulus
GO_0006412Biological processtranslation
GO_2000766Biological processnegative regulation of cytoplasmic translation
GO_0071230Biological processcellular response to amino acid stimulus
GO_0071456Biological processcellular response to hypoxia
GO_0031440Biological processregulation of mRNA 3'-end processing
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_1990124Cellular componentmessenger ribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0043022Molecular functionribosome binding
GO_0000900Molecular functionmRNA regulatory element binding translation repressor activity
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0046872Molecular functionmetal ion binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCPEB1
Protein nameCytoplasmic polyadenylation element binding protein 1, isoform CRA_c (Cytoplasmic polyadenylation element-binding protein 1)
Cytoplasmic polyadenylation element binding protein 1
Cytoplasmic polyadenylation element-binding protein 1
Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)
SynonymsCPEB
hCG_26948
DescriptionFUNCTION: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism . In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry . .

AccessionsENST00000569257.5
ENST00000616775.4 [Q9BZB8-2]
ENST00000634018.1
A0A0J9YX15
ENST00000633271.1
ENST00000631406.1
H3BTE4
ENST00000620212.4 [Q9BZB8-4]
A0A087WXG7
ENST00000631674.1 [Q9BZB8-4]
H3BPD6
A0A0J9YXP0
ENST00000684509.1
ENST00000617522.4 [Q9BZB8-4]
A0A087X171
ENST00000619696.2 [Q9BZB8-4]
ENST00000610719.3
ENST00000632305.1
ENST00000611031.4
ENST00000568994.1
ENST00000620182.4 [Q9BZB8-4]
ENST00000633293.1
ENST00000617958.4
ENST00000567678.1
ENST00000618449.4 [Q9BZB8-2]
A0A024R214
ENST00000632526.1 [Q9BZB8-4]
ENST00000632883.1
ENST00000611163.4 [Q9BZB8-4]
ENST00000614977.4
A0A087WVR7
H3BNX1
ENST00000617462.4 [Q9BZB8-4]
Q9BZB8
ENST00000616959.4
ENST00000614918.4
A0A087WUQ9
ENST00000632172.1
ENST00000615198.4 [Q9BZB8-3]