APP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032722Biological processpositive regulation of chemokine production
GO_1905908Biological processpositive regulation of amyloid fibril formation
GO_0010468Biological processregulation of gene expression
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0035235Biological processionotropic glutamate receptor signaling pathway
GO_0014005Biological processmicroglia development
GO_0050885Biological processneuromuscular process controlling balance
GO_0050730Biological processregulation of peptidyl-tyrosine phosphorylation
GO_0051402Biological processneuron apoptotic process
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_0007417Biological processcentral nervous system development
GO_1900272Biological processnegative regulation of long-term synaptic potentiation
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0006468Biological processprotein phosphorylation
GO_0030111Biological processregulation of Wnt signaling pathway
GO_0006979Biological processresponse to oxidative stress
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0007626Biological processlocomotory behavior
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006897Biological processendocytosis
GO_0007219Biological processNotch signaling pathway
GO_0010629Biological processnegative regulation of gene expression
GO_0007612Biological processlearning
GO_0048143Biological processastrocyte activation
GO_0030900Biological processforebrain development
GO_0031175Biological processneuron projection development
GO_0010628Biological processpositive regulation of gene expression
GO_0007155Biological processcell adhesion
GO_0008542Biological processvisual learning
GO_0051124Biological processsynaptic assembly at neuromuscular junction
GO_0007617Biological processmating behavior
GO_0050729Biological processpositive regulation of inflammatory response
GO_2000406Biological processpositive regulation of T cell migration
GO_0006878Biological processintracellular copper ion homeostasis
GO_0045821Biological processpositive regulation of glycolytic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0098989Biological processNMDA selective glutamate receptor signaling pathway
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0048169Biological processregulation of long-term neuronal synaptic plasticity
GO_0001774Biological processmicroglial cell activation
GO_0016322Biological processneuron remodeling
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0048669Biological processcollateral sprouting in absence of injury
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0002265Biological processastrocyte activation involved in immune response
GO_0098815Biological processmodulation of excitatory postsynaptic potential
GO_0007409Biological processaxonogenesis
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0016199Biological processaxon midline choice point recognition
GO_0050808Biological processsynapse organization
GO_1904646Biological processcellular response to amyloid-beta
GO_0050803Biological processregulation of synapse structure or activity
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_1905606Biological processregulation of presynapse assembly
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0007611Biological processlearning or memory
GO_0046330Biological processpositive regulation of JNK cascade
GO_0008344Biological processadult locomotory behavior
GO_0008203Biological processcholesterol metabolic process
GO_0030198Biological processextracellular matrix organization
GO_1990535Biological processneuron projection maintenance
GO_0070555Biological processresponse to interleukin-1
GO_0040014Biological processregulation of multicellular organism growth
GO_0051563Biological processsmooth endoplasmic reticulum calcium ion homeostasis
GO_0180011Biological processcytosolic mRNA polyadenylation
GO_0006417Biological processregulation of translation
GO_0007176Biological processregulation of epidermal growth factor-activated receptor activity
GO_0070050Biological processneuron cellular homeostasis
GO_1990000Biological processamyloid fibril formation
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0008088Biological processaxo-dendritic transport
GO_0150003Biological processregulation of spontaneous synaptic transmission
GO_0050890Biological processcognition
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0016358Biological processdendrite development
GO_0001967Biological processsuckling behavior
GO_0045121Cellular componentmembrane raft
GO_0035253Cellular componentciliary rootlet
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0051233Cellular componentspindle midzone
GO_0008021Cellular componentsynaptic vesicle
GO_0005768Cellular componentendosome
GO_0031904Cellular componentendosome lumen
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0030425Cellular componentdendrite
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0030134Cellular componentCOPII-coated ER to Golgi transport vesicle
GO_0005798Cellular componentGolgi-associated vesicle
GO_0005615Cellular componentextracellular space
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005641Cellular componentnuclear envelope lumen
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0043198Cellular componentdendritic shaft
GO_0005769Cellular componentearly endosome
GO_0005790Cellular componentsmooth endoplasmic reticulum
GO_0043204Cellular componentperikaryon
GO_0005794Cellular componentGolgi apparatus
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005905Cellular componentclathrin-coated pit
GO_0030424Cellular componentaxon
GO_0045177Cellular componentapical part of cell
GO_0031594Cellular componentneuromuscular junction
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005796Cellular componentGolgi lumen
GO_0005911Cellular componentcell-cell junction
GO_0048786Cellular componentpresynaptic active zone
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0030426Cellular componentgrowth cone
GO_0048018Molecular functionreceptor ligand activity
GO_0042802Molecular functionidentical protein binding
GO_0046914Molecular functiontransition metal ion binding
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0030546Molecular functionsignaling receptor activator activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005102Molecular functionsignaling receptor binding
GO_0019899Molecular functionenzyme binding
GO_0008201Molecular functionheparin binding
GO_0051425Molecular functionPTB domain binding
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity

IV. Literature review

[source]
Gene nameAPP
Protein nameAmyloid-beta precursor protein (ABPP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein)
Amyloid beta protein
Alternative protein APP
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Amyloid beta A4 protein
Amyloid-beta A4 protein
SynonymsAD1
A4
DescriptionFUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. .; FUNCTION: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). .; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. .

FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. .; FUNCTION: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). .; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. .

FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis . Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons . Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. .; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. .; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.; FUNCTION: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. .

FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. .

FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. .

FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. .

AccessionsQ9BYY9
H7C2L2
ENST00000357903.7 [P05067-8]
ENST00000448850.5
ENST00000358918.7 [P05067-9]
L7XE61
ENST00000346798.8 [P05067-1]
ENST00000439274.6
ENST00000359726.7
ENST00000354192.7 [P05067-10]
L7XCZ9
A0A0A0MRG2
P05067
ENST00000348990.9 [P05067-4]
ENST00000415997.1
ENST00000440126.7 [P05067-11]
L8EC46
A0A8F9R5D5
A0A218KGR2
E9PG40
H7C0V9