CYFIP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	28% ± 9%	Explore
B cell	26 studies	28% ± 7%	Explore
CD8-positive, alpha-beta T cell	26 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	21 studies	25% ± 6%	Explore
T cell	20 studies	26% ± 7%	Explore
regulatory T cell	19 studies	25% ± 6%	Explore
plasmacytoid dendritic cell	16 studies	33% ± 10%	Explore
memory B cell	15 studies	25% ± 8%	Explore
naive B cell	15 studies	26% ± 7%	Explore
mature NK T cell	14 studies	26% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	30% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	38% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	26% ± 5%	Explore
astrocyte	14 studies	37% ± 19%	Explore
gamma-delta T cell	14 studies	31% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	30% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	26% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	31% ± 8%	Explore
glutamatergic neuron	12 studies	48% ± 22%	Explore
oligodendrocyte precursor cell	12 studies	45% ± 18%	Explore
mucosal invariant T cell	11 studies	28% ± 7%	Explore
GABAergic neuron	10 studies	48% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	30% ± 8%	Explore
non-classical monocyte	9 studies	28% ± 12%	Explore
kidney loop of Henle epithelial cell	7 studies	42% ± 14%	Explore
interneuron	7 studies	47% ± 27%	Explore
precursor B cell	7 studies	46% ± 15%	Explore
neuron	6 studies	35% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	23% ± 7%	Explore
amacrine cell	5 studies	24% ± 6%	Explore
retinal ganglion cell	5 studies	49% ± 21%	Explore
lymphocyte	5 studies	35% ± 16%	Explore
pro-B cell	5 studies	48% ± 11%	Explore
immature B cell	5 studies	41% ± 13%	Explore
retina horizontal cell	5 studies	33% ± 8%	Explore
oligodendrocyte	5 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	28% ± 6%	Explore
exhausted T cell	4 studies	30% ± 7%	Explore
granule cell	4 studies	35% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	40% ± 5%	Explore
retinal bipolar neuron	4 studies	20% ± 3%	Explore
ON-bipolar cell	4 studies	22% ± 4%	Explore
T follicular helper cell	4 studies	29% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 7%	Explore
renal principal cell	4 studies	41% ± 6%	Explore
plasmablast	3 studies	29% ± 8%	Explore
hematopoietic precursor cell	3 studies	35% ± 9%	Explore
endothelial cell	3 studies	45% ± 12%	Explore
GABAergic interneuron	3 studies	45% ± 2%	Explore
OFF-bipolar cell	3 studies	26% ± 4%	Explore
rod bipolar cell	3 studies	20% ± 3%	Explore
germinal center B cell	3 studies	22% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	29% ± 2%	Explore
epithelial cell	3 studies	22% ± 4%	Explore
dendritic cell	3 studies	25% ± 6%	Explore
double negative thymocyte	3 studies	40% ± 6%	Explore
renal alpha-intercalated cell	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	36% ± 19%	Explore
peripheral blood	13 studies	25% ± 4%	Explore
kidney	6 studies	28% ± 7%	Explore
eye	4 studies	18% ± 2%	Explore
lymph node	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	16504.57	2629 / 2642	100%	55.99	703 / 705
kidney	100%	13223.73	89 / 89	99%	50.81	894 / 901
adrenal gland	84%	3125.90	217 / 258	87%	21.85	201 / 230
stomach	89%	3404.64	320 / 359	82%	12.33	235 / 286
lung	90%	2721.23	518 / 578	70%	10.19	809 / 1155
thymus	59%	1552.23	386 / 653	98%	26.28	590 / 605
bladder	71%	2084.76	15 / 21	70%	9.98	354 / 504
intestine	50%	1794.96	487 / 966	84%	12.23	444 / 527
liver	61%	1853.98	137 / 226	65%	12.54	262 / 406
prostate	22%	451.91	53 / 245	97%	15.72	489 / 502
ovary	8%	166.78	15 / 180	93%	14.94	400 / 430
uterus	46%	1093.89	79 / 170	54%	9.94	250 / 459
lymph node	0%	0	0 / 0	100%	72.73	29 / 29
spleen	100%	7502.63	241 / 241	0%	0	0 / 0
peripheral blood	99%	12861.16	919 / 929	0%	0	0 / 0
blood vessel	99%	6915.15	1315 / 1335	0%	0	0 / 0
breast	5%	126.51	25 / 459	78%	15.48	872 / 1118
skin	9%	223.31	162 / 1809	73%	14.10	346 / 472
pancreas	4%	77.77	12 / 328	75%	10.27	133 / 178
tonsil	0%	0	0 / 0	69%	9.86	31 / 45
esophagus	16%	413.26	227 / 1445	49%	5.65	90 / 183
heart	59%	1504.27	505 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	29%	2.80	23 / 80
adipose	17%	485.90	207 / 1204	0%	0	0 / 0
muscle	6%	128.13	45 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0150052	Biological process	regulation of postsynapse assembly
GO_0030833	Biological process	regulation of actin filament polymerization
GO_0045862	Biological process	positive regulation of proteolysis
GO_0097484	Biological process	dendrite extension
GO_0051388	Biological process	positive regulation of neurotrophin TRK receptor signaling pathway
GO_0030031	Biological process	cell projection assembly
GO_0097202	Biological process	activation of cysteine-type endopeptidase activity
GO_0006915	Biological process	apoptotic process
GO_0000902	Biological process	cell morphogenesis
GO_0098609	Biological process	cell-cell adhesion
GO_0007411	Biological process	axon guidance
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0043005	Cellular component	neuron projection
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0031209	Cellular component	SCAR complex
GO_0005634	Cellular component	nucleus
GO_0000340	Molecular function	RNA 7-methylguanosine cap binding
GO_0031267	Molecular function	small GTPase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CYFIP2
Protein name	Cytoplasmic FMR1 interacting protein 2 Alternative protein CYFIP2 Cytoplasmic FMR1-interacting protein Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Synonyms	PIR121 KIAA1168
Description	FUNCTION: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). .
Accessions	A0A087WWZ1 E5RKA3 E7EW33 ENST00000618329.4 [Q96F07-2] ENST00000621516.1 ENST00000620254.5 [Q96F07-2] ENST00000611075.4 ENST00000520960.2 H7C229 Q96F07 E7EVJ5 A0A087WV63 ENST00000521420.5 A0A087WZL7 A0A087WVE1 ENST00000435847.6 ENST00000611925.4 A0A087WTQ3 A0A8V8TNU3 ENST00000617629.4 ENST00000616178.4 [Q96F07-1] ENST00000698888.1 ENST00000522463.5 ENST00000522637.5 L0R6F7

CYFIP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review