TUFM | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	31% ± 11%	Explore
B cell	32 studies	32% ± 10%	Explore
fibroblast	31 studies	31% ± 12%	Explore
endothelial cell	28 studies	32% ± 13%	Explore
CD4-positive, alpha-beta T cell	28 studies	34% ± 16%	Explore
CD8-positive, alpha-beta T cell	27 studies	37% ± 15%	Explore
conventional dendritic cell	26 studies	39% ± 16%	Explore
macrophage	25 studies	28% ± 10%	Explore
T cell	24 studies	33% ± 11%	Explore
smooth muscle cell	23 studies	31% ± 12%	Explore
pericyte	21 studies	33% ± 10%	Explore
basal cell	20 studies	40% ± 17%	Explore
classical monocyte	20 studies	31% ± 13%	Explore
regulatory T cell	20 studies	36% ± 12%	Explore
memory B cell	19 studies	32% ± 10%	Explore
non-classical monocyte	19 studies	33% ± 14%	Explore
epithelial cell	19 studies	43% ± 20%	Explore
naive B cell	18 studies	27% ± 6%	Explore
plasmacytoid dendritic cell	17 studies	35% ± 13%	Explore
ciliated cell	17 studies	57% ± 17%	Explore
gamma-delta T cell	17 studies	34% ± 14%	Explore
monocyte	16 studies	28% ± 9%	Explore
plasma cell	15 studies	48% ± 18%	Explore
connective tissue cell	15 studies	36% ± 15%	Explore
endothelial cell of lymphatic vessel	14 studies	36% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	30% ± 8%	Explore
mature NK T cell	13 studies	33% ± 8%	Explore
mast cell	12 studies	21% ± 4%	Explore
plasmablast	12 studies	52% ± 25%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	38% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	34% ± 10%	Explore
capillary endothelial cell	12 studies	27% ± 12%	Explore
myofibroblast cell	12 studies	37% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	35% ± 12%	Explore
dendritic cell	11 studies	48% ± 23%	Explore
vein endothelial cell	11 studies	28% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	34% ± 11%	Explore
secretory cell	10 studies	36% ± 13%	Explore
abnormal cell	10 studies	40% ± 13%	Explore
endothelial cell of artery	10 studies	26% ± 7%	Explore
mucosal invariant T cell	10 studies	34% ± 8%	Explore
endothelial cell of vascular tree	10 studies	26% ± 7%	Explore
myeloid cell	10 studies	31% ± 12%	Explore
progenitor cell	9 studies	55% ± 13%	Explore
type I pneumocyte	8 studies	32% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	35% ± 12%	Explore
club cell	7 studies	39% ± 7%	Explore
neuron	7 studies	42% ± 20%	Explore
astrocyte	7 studies	27% ± 14%	Explore
T follicular helper cell	7 studies	28% ± 5%	Explore
ionocyte	6 studies	33% ± 12%	Explore
respiratory goblet cell	6 studies	38% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	45% ± 17%	Explore
leukocyte	6 studies	31% ± 10%	Explore
epithelial cell of proximal tubule	6 studies	40% ± 11%	Explore
renal alpha-intercalated cell	6 studies	56% ± 8%	Explore
goblet cell	6 studies	41% ± 9%	Explore
mesothelial cell	6 studies	44% ± 19%	Explore
transit amplifying cell	6 studies	45% ± 21%	Explore
hematopoietic stem cell	6 studies	48% ± 12%	Explore
precursor B cell	6 studies	38% ± 12%	Explore
innate lymphoid cell	6 studies	28% ± 6%	Explore
type II pneumocyte	6 studies	35% ± 14%	Explore
erythrocyte	6 studies	37% ± 26%	Explore
hematopoietic precursor cell	5 studies	56% ± 23%	Explore
exhausted T cell	5 studies	42% ± 9%	Explore
mononuclear phagocyte	5 studies	35% ± 19%	Explore
kidney loop of Henle epithelial cell	5 studies	42% ± 8%	Explore
enterocyte	5 studies	38% ± 10%	Explore
enteroendocrine cell	5 studies	45% ± 18%	Explore
intestinal crypt stem cell	5 studies	44% ± 17%	Explore
erythroblast	5 studies	55% ± 20%	Explore
pro-B cell	5 studies	43% ± 11%	Explore
alveolar macrophage	5 studies	21% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	40% ± 15%	Explore
deuterosomal cell	4 studies	29% ± 8%	Explore
pancreatic A cell	4 studies	43% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	59% ± 10%	Explore
IgA plasma cell	4 studies	28% ± 12%	Explore
IgG plasma cell	4 studies	27% ± 13%	Explore
retinal ganglion cell	4 studies	55% ± 27%	Explore
brush cell	4 studies	27% ± 16%	Explore
immature B cell	4 studies	44% ± 17%	Explore
adventitial cell	4 studies	26% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	47% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	42% ± 11%	Explore
oligodendrocyte precursor cell	4 studies	33% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	56% ± 24%	Explore
T-helper 17 cell	4 studies	36% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	34% ± 9%	Explore
duct epithelial cell	3 studies	36% ± 10%	Explore
precursor cell	3 studies	64% ± 6%	Explore
squamous epithelial cell	3 studies	39% ± 25%	Explore
type B pancreatic cell	3 studies	47% ± 4%	Explore
glomerular endothelial cell	3 studies	21% ± 6%	Explore
neural crest cell	3 studies	49% ± 5%	Explore
retinal bipolar neuron	3 studies	39% ± 12%	Explore
placental villous trophoblast	3 studies	60% ± 18%	Explore
common myeloid progenitor	3 studies	47% ± 19%	Explore
lymphocyte	3 studies	40% ± 8%	Explore
neuroendocrine cell	3 studies	40% ± 13%	Explore
amacrine cell	3 studies	38% ± 14%	Explore
retina horizontal cell	3 studies	36% ± 17%	Explore
retinal cone cell	3 studies	53% ± 15%	Explore
retinal rod cell	3 studies	35% ± 13%	Explore
mucus secreting cell	3 studies	28% ± 8%	Explore
serous secreting cell	3 studies	37% ± 5%	Explore
intraepithelial lymphocyte	3 studies	32% ± 16%	Explore
Mueller cell	3 studies	30% ± 7%	Explore
germinal center B cell	3 studies	44% ± 4%	Explore
intermediate monocyte	3 studies	43% ± 20%	Explore
myoepithelial cell	3 studies	40% ± 8%	Explore
GABAergic neuron	3 studies	28% ± 5%	Explore
glutamatergic neuron	3 studies	38% ± 7%	Explore
pancreatic ductal cell	3 studies	58% ± 9%	Explore
granulocyte monocyte progenitor cell	3 studies	48% ± 24%	Explore
granulocyte	3 studies	29% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 15%	Explore
keratinocyte	3 studies	29% ± 3%	Explore
T-helper 1 cell	3 studies	42% ± 14%	Explore
double negative thymocyte	3 studies	52% ± 15%	Explore
progenitor cell of mammary luminal epithelium	3 studies	44% ± 10%	Explore
hepatocyte	3 studies	45% ± 24%	Explore
luminal cell of prostate epithelium	3 studies	22% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	37% ± 14%	Explore
peripheral blood	16 studies	36% ± 11%	Explore
intestine	11 studies	32% ± 15%	Explore
kidney	8 studies	34% ± 7%	Explore
eye	7 studies	28% ± 13%	Explore
liver	7 studies	31% ± 19%	Explore
brain	6 studies	26% ± 8%	Explore
bone marrow	5 studies	24% ± 9%	Explore
lymph node	5 studies	38% ± 10%	Explore
pancreas	4 studies	42% ± 13%	Explore
uterus	4 studies	38% ± 17%	Explore
breast	4 studies	32% ± 6%	Explore
adrenal gland	3 studies	28% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7506.82	1445 / 1445	100%	185.45	183 / 183
liver	100%	8682.09	226 / 226	100%	279.55	406 / 406
ovary	100%	6515.23	180 / 180	100%	252.53	430 / 430
pancreas	100%	6418.05	328 / 328	100%	251.43	178 / 178
skin	100%	8944.14	1809 / 1809	100%	381.80	472 / 472
thymus	100%	7759.90	653 / 653	100%	250.36	604 / 605
uterus	100%	6926.64	170 / 170	100%	323.69	458 / 459
brain	100%	6251.05	2636 / 2642	100%	322.69	705 / 705
kidney	100%	9954.61	89 / 89	100%	289.68	898 / 901
intestine	100%	8901.35	966 / 966	100%	415.76	525 / 527
lung	100%	6909.68	577 / 578	99%	270.60	1149 / 1155
stomach	100%	8193.84	359 / 359	99%	332.83	284 / 286
prostate	100%	7227.59	245 / 245	99%	302.99	498 / 502
adrenal gland	100%	11522.27	258 / 258	99%	237.55	228 / 230
bladder	100%	7196.81	21 / 21	99%	360.82	499 / 504
breast	100%	7346.11	459 / 459	99%	325.79	1106 / 1118
adipose	100%	7185.91	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	438.12	80 / 80
lymph node	0%	0	0 / 0	100%	454.42	29 / 29
muscle	100%	12465.69	803 / 803	0%	0	0 / 0
spleen	100%	7966.98	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	301.66	45 / 45
ureter	0%	0	0 / 0	100%	235.84	1 / 1
blood vessel	100%	5479.73	1332 / 1335	0%	0	0 / 0
heart	98%	9947.00	848 / 861	0%	0	0 / 0
peripheral blood	94%	5458.17	873 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006414	Biological process	translational elongation
GO_0045471	Biological process	response to ethanol
GO_0070125	Biological process	mitochondrial translational elongation
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005739	Cellular component	mitochondrion
GO_0045202	Cellular component	synapse
GO_0042645	Cellular component	mitochondrial nucleoid
GO_0016020	Cellular component	membrane
GO_0005525	Molecular function	GTP binding
GO_0003924	Molecular function	GTPase activity
GO_0003746	Molecular function	translation elongation factor activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	TUFM
Protein name	Elongation factor Tu Elongation factor Tu, mitochondrial Elongation factor Tu, mitochondrial (EF-Tu) (P43)
Synonyms	hCG_1747191
Description	FUNCTION: Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. .
Accessions	P49411 H3BNU3 ENST00000313511.8 ENST00000565012.1 A0A384ME17

TUFM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review