SYT7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001778Biological processplasma membrane repair
GO_0036465Biological processsynaptic vesicle recycling
GO_0050796Biological processregulation of insulin secretion
GO_0048791Biological processcalcium ion-regulated exocytosis of neurotransmitter
GO_1900242Biological processregulation of synaptic vesicle endocytosis
GO_0046850Biological processregulation of bone remodeling
GO_1990926Biological processshort-term synaptic potentiation
GO_0090385Biological processphagosome-lysosome fusion
GO_0045956Biological processpositive regulation of calcium ion-dependent exocytosis
GO_0006909Biological processphagocytosis
GO_0050764Biological processregulation of phagocytosis
GO_0070092Biological processregulation of glucagon secretion
GO_0090119Biological processvesicle-mediated cholesterol transport
GO_1990927Biological processcalcium ion regulated lysosome exocytosis
GO_0006906Biological processvesicle fusion
GO_0005778Cellular componentperoxisomal membrane
GO_0005886Cellular componentplasma membrane
GO_0032009Cellular componentearly phagosome
GO_0005764Cellular componentlysosome
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0005777Cellular componentperoxisome
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0042734Cellular componentpresynaptic membrane
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0045202Cellular componentsynapse
GO_0031045Cellular componentdense core granule
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0030424Cellular componentaxon
GO_0005765Cellular componentlysosomal membrane
GO_0005544Molecular functioncalcium-dependent phospholipid binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0000149Molecular functionSNARE binding
GO_0030276Molecular functionclathrin binding
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameSYT7
Protein nameAlternative protein SYT7 (cDNA FLJ53554)
Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)
Synaptotagmin 7
SynonymsPCANAP7
DescriptionFUNCTION: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair . Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis . Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). .

AccessionsF5GX00
ENST00000542836.5 [O43581-6]
O43581
ENST00000540677.5 [O43581-2]
ENST00000539468.5
F5H8G7
ENST00000545053.1
ENST00000535826.5 [O43581-5]
B4DGK4
ENST00000263846.8 [O43581-1]
ENST00000539246.5
ENST00000539008.6 [O43581-3]
ENST00000542670.5 [O43581-4]