Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 9 studies | 26% ± 6% | |
| retinal rod cell | 8 studies | 30% ± 3% | |
| mesothelial cell | 6 studies | 29% ± 11% | |
| retinal cone cell | 5 studies | 35% ± 6% | |
| epithelial cell | 5 studies | 28% ± 12% | |
| Mueller cell | 5 studies | 39% ± 9% | |
| abnormal cell | 4 studies | 24% ± 9% | |
| retinal pigment epithelial cell | 4 studies | 51% ± 9% | |
| cardiac muscle cell | 4 studies | 22% ± 2% | |
| astrocyte | 3 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 2960.31 | 2599 / 2642 | 100% | 88.40 | 705 / 705 |
| intestine | 99% | 4520.32 | 957 / 966 | 97% | 70.73 | 513 / 527 |
| skin | 98% | 3524.00 | 1780 / 1809 | 98% | 69.03 | 462 / 472 |
| esophagus | 97% | 2323.72 | 1408 / 1445 | 97% | 77.45 | 177 / 183 |
| uterus | 98% | 4078.61 | 167 / 170 | 88% | 66.49 | 402 / 459 |
| stomach | 88% | 2353.41 | 316 / 359 | 97% | 68.26 | 278 / 286 |
| liver | 100% | 3112.28 | 225 / 226 | 84% | 46.75 | 343 / 406 |
| ovary | 94% | 1382.10 | 169 / 180 | 85% | 32.17 | 364 / 430 |
| prostate | 81% | 1136.95 | 199 / 245 | 94% | 47.33 | 472 / 502 |
| adrenal gland | 99% | 1896.90 | 255 / 258 | 57% | 16.52 | 131 / 230 |
| breast | 87% | 1223.47 | 398 / 459 | 65% | 27.30 | 728 / 1118 |
| bladder | 86% | 2219.00 | 18 / 21 | 64% | 46.56 | 324 / 504 |
| lung | 69% | 814.04 | 396 / 578 | 69% | 46.69 | 800 / 1155 |
| kidney | 58% | 840.61 | 52 / 89 | 72% | 41.82 | 652 / 901 |
| muscle | 100% | 3949.33 | 803 / 803 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 21.28 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 75.49 | 44 / 45 |
| heart | 97% | 5326.10 | 837 / 861 | 0% | 0 | 0 / 0 |
| adipose | 97% | 2506.40 | 1169 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 48.53 | 76 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 32.92 | 26 / 29 |
| blood vessel | 86% | 1568.36 | 1153 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 84% | 886.51 | 202 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 2% | 14.50 | 6 / 328 | 81% | 30.51 | 144 / 178 |
| thymus | 48% | 415.12 | 312 / 653 | 26% | 5.99 | 156 / 605 |
| peripheral blood | 23% | 1313.31 | 214 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0050796 | Biological process | regulation of insulin secretion |
| GO_0051780 | Biological process | behavioral response to nutrient |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0015728 | Biological process | mevalonate transport |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0071422 | Biological process | succinate transmembrane transport |
| GO_1901475 | Biological process | pyruvate transmembrane transport |
| GO_0007098 | Biological process | centrosome cycle |
| GO_1905039 | Biological process | carboxylic acid transmembrane transport |
| GO_0035879 | Biological process | plasma membrane lactate transport |
| GO_0042867 | Biological process | pyruvate catabolic process |
| GO_0015718 | Biological process | monocarboxylic acid transport |
| GO_0032094 | Biological process | response to food |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0071407 | Biological process | cellular response to organic cyclic compound |
| GO_1902600 | Biological process | proton transmembrane transport |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0009925 | Cellular component | basal plasma membrane |
| GO_0045202 | Cellular component | synapse |
| GO_0016328 | Cellular component | lateral plasma membrane |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030054 | Cellular component | cell junction |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0046943 | Molecular function | carboxylic acid transmembrane transporter activity |
| GO_0015650 | Molecular function | lactate:proton symporter activity |
| GO_0015129 | Molecular function | lactate transmembrane transporter activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0097159 | Molecular function | organic cyclic compound binding |
| GO_0008028 | Molecular function | monocarboxylic acid transmembrane transporter activity |
| GO_0015130 | Molecular function | mevalonate transmembrane transporter activity |
| GO_0015141 | Molecular function | succinate transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SLC16A1 |
| Protein name | Monocarboxylate transporter 1 (Solute carrier family 16 member 1) Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) Monocarboxylate transporter 1 |
| Synonyms | hCG_37455 MCT1 |
| Description | FUNCTION: Bidirectional proton-coupled monocarboxylate transporter . Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH . The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart . Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition . . |
| Accessions | ENST00000369626.8 [P53985-1] ENST00000628110.2 [P53985-1] Q5T8R5 ENST00000443580.6 [P53985-1] ENST00000626371 Q5T8R4 ENST00000443580 ENST00000538576.5 [P53985-1] ENST00000629920 ENST00000630362.4 [P53985-1] ENST00000458229.6 [P53985-1] P53985 ENST00000679803.1 [P53985-1] ENST00000458229 Q5T8R3 ENST00000429288.2 [P53985-1] ENST00000629508 ENST00000429288 |
