Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 11 studies | 63% ± 25% | |
| GABAergic neuron | 7 studies | 67% ± 16% | |
| interneuron | 5 studies | 50% ± 24% | |
| neuron | 4 studies | 40% ± 21% | |
| endothelial cell | 4 studies | 38% ± 24% | |
| granule cell | 4 studies | 28% ± 13% | |
| retinal ganglion cell | 4 studies | 69% ± 17% | |
| amacrine cell | 3 studies | 28% ± 6% | |
| GABAergic interneuron | 3 studies | 48% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 12 studies | 40% ± 23% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 94% | 24783.88 | 2486 / 2642 | 81% | 27.13 | 574 / 705 |
| prostate | 5% | 101.72 | 12 / 245 | 99% | 5.09 | 497 / 502 |
| breast | 0% | 0 | 0 / 459 | 39% | 1.21 | 441 / 1118 |
| intestine | 1% | 17.26 | 8 / 966 | 32% | 1.12 | 170 / 527 |
| stomach | 0% | 0 | 0 / 359 | 25% | 0.50 | 71 / 286 |
| lung | 0% | 0 | 0 / 578 | 18% | 0.46 | 211 / 1155 |
| esophagus | 0% | 0 | 0 / 1445 | 13% | 0.30 | 24 / 183 |
| bladder | 0% | 0 | 0 / 21 | 12% | 0.31 | 58 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.20 | 5 / 45 |
| uterus | 0% | 0 | 0 / 170 | 10% | 0.30 | 47 / 459 |
| pancreas | 0% | 0 | 0 / 328 | 9% | 0.55 | 16 / 178 |
| ovary | 0% | 0 | 0 / 180 | 6% | 0.12 | 27 / 430 |
| adrenal gland | 0% | 19.00 | 1 / 258 | 5% | 0.47 | 12 / 230 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.48 | 2 / 80 |
| skin | 0% | 0 | 0 / 1809 | 1% | 0.03 | 7 / 472 |
| thymus | 0% | 0 | 0 / 653 | 1% | 0.02 | 8 / 605 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.02 | 4 / 406 |
| kidney | 0% | 0 | 0 / 89 | 1% | 0.02 | 7 / 901 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0055074 | Biological process | calcium ion homeostasis |
| GO_0042391 | Biological process | regulation of membrane potential |
| GO_0097553 | Biological process | calcium ion transmembrane import into cytosol |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0010524 | Biological process | positive regulation of calcium ion transport into cytosol |
| GO_0060079 | Biological process | excitatory postsynaptic potential |
| GO_0035235 | Biological process | ionotropic glutamate receptor signaling pathway |
| GO_1903428 | Biological process | positive regulation of reactive oxygen species biosynthetic process |
| GO_0018964 | Biological process | propylene metabolic process |
| GO_0098976 | Biological process | excitatory chemical synaptic transmission |
| GO_0045471 | Biological process | response to ethanol |
| GO_2000463 | Biological process | positive regulation of excitatory postsynaptic potential |
| GO_0008542 | Biological process | visual learning |
| GO_1905429 | Biological process | response to glycine |
| GO_0048167 | Biological process | regulation of synaptic plasticity |
| GO_1904062 | Biological process | regulation of monoatomic cation transmembrane transport |
| GO_0048168 | Biological process | regulation of neuronal synaptic plasticity |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0098655 | Biological process | monoatomic cation transmembrane transport |
| GO_0051290 | Biological process | protein heterotetramerization |
| GO_0006812 | Biological process | monoatomic cation transport |
| GO_0007420 | Biological process | brain development |
| GO_0051968 | Biological process | positive regulation of synaptic transmission, glutamatergic |
| GO_1904646 | Biological process | cellular response to amyloid-beta |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0097060 | Cellular component | synaptic membrane |
| GO_0043195 | Cellular component | terminal bouton |
| GO_0043005 | Cellular component | neuron projection |
| GO_0030425 | Cellular component | dendrite |
| GO_0009986 | Cellular component | cell surface |
| GO_0008021 | Cellular component | synaptic vesicle |
| GO_0045202 | Cellular component | synapse |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0043083 | Cellular component | synaptic cleft |
| GO_0060076 | Cellular component | excitatory synapse |
| GO_0017146 | Cellular component | NMDA selective glutamate receptor complex |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0004972 | Molecular function | NMDA glutamate receptor activity |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0015276 | Molecular function | ligand-gated monoatomic ion channel activity |
| GO_0016595 | Molecular function | glutamate binding |
| GO_0016594 | Molecular function | glycine binding |
| GO_0022849 | Molecular function | glutamate-gated calcium ion channel activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005262 | Molecular function | calcium channel activity |
| Gene name | GRIN1 |
| Protein name | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) Glutamate receptor Glutamate ionotropic receptor NMDA type subunit 1 Putative NMDtranscript(AltAcc_e2) |
| Synonyms | NMDAR1 |
| Description | FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) . Sensitivity to glutamate and channel kinetics depend on the subunit composition . . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . |
| Accessions | ENST00000350902.9 ENST00000371553.8 [Q05586-6] A2AVK2 Q5VSF9 A0A8D9UIZ0 Q05586 ENST00000371550.8 [Q05586-3] ENST00000371561.8 [Q05586-1] ENST00000371555.8 ENST00000371546.8 [Q05586-5] ENST00000371560.5 [Q05586-7] ENST00000371559.8 [Q05586-2] |
