I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pancreatic A cell | 3 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pancreatic A cell | 3 studies | 23% ± 5% |
Insufficient scRNA-seq data for expression of CRH at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 62% | 58.35 | 203 / 328 | 44% | 4.99 | 79 / 178 |
| brain | 65% | 478.03 | 1722 / 2642 | 35% | 1.77 | 246 / 705 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.79 | 1 / 1 |
| adrenal gland | 12% | 14.03 | 31 / 258 | 30% | 116.29 | 69 / 230 |
| bladder | 0% | 0 | 0 / 21 | 31% | 98.91 | 155 / 504 |
| kidney | 3% | 1.42 | 3 / 89 | 4% | 2.00 | 39 / 901 |
| uterus | 0% | 0 | 0 / 170 | 8% | 2.10 | 35 / 459 |
| intestine | 0% | 0.07 | 1 / 966 | 2% | 0.22 | 12 / 527 |
| stomach | 1% | 0.31 | 3 / 359 | 1% | 0.03 | 4 / 286 |
| breast | 1% | 0.32 | 4 / 459 | 1% | 0.18 | 15 / 1118 |
| lung | 0% | 0 | 0 / 578 | 2% | 0.47 | 25 / 1155 |
| thymus | 0% | 0.20 | 2 / 653 | 2% | 0.05 | 11 / 605 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| esophagus | 0% | 0 | 0 / 1445 | 1% | 0.02 | 2 / 183 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.29 | 4 / 406 |
| skin | 0% | 0.59 | 5 / 1809 | 1% | 0.01 | 3 / 472 |
| adipose | 1% | 0.62 | 9 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 0% | 0 | 0 / 245 | 1% | 0.02 | 3 / 502 |
| ovary | 0% | 0 | 0 / 180 | 0% | 0.01 | 1 / 430 |
| heart | 0% | 0.08 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| GO_0030324 | Biological process | lung development |
| GO_0006954 | Biological process | inflammatory response |
| GO_0060456 | Biological process | positive regulation of digestive system process |
| GO_0071549 | Biological process | cellular response to dexamethasone stimulus |
| GO_0043627 | Biological process | response to estrogen |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0007611 | Biological process | learning or memory |
| GO_0008628 | Biological process | hormone-mediated apoptotic signaling pathway |
| GO_0007165 | Biological process | signal transduction |
| GO_0035902 | Biological process | response to immobilization stress |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0006704 | Biological process | glucocorticoid biosynthetic process |
| GO_2000310 | Biological process | regulation of NMDA receptor activity |
| GO_0008306 | Biological process | associative learning |
| GO_2000987 | Biological process | positive regulation of behavioral fear response |
| GO_0033685 | Biological process | negative regulation of luteinizing hormone secretion |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0060291 | Biological process | long-term synaptic potentiation |
| GO_0045471 | Biological process | response to ethanol |
| GO_0007565 | Biological process | female pregnancy |
| GO_0070093 | Biological process | negative regulation of glucagon secretion |
| GO_0035774 | Biological process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| GO_0003085 | Biological process | negative regulation of systemic arterial blood pressure |
| GO_0051402 | Biological process | neuron apoptotic process |
| GO_0071314 | Biological process | cellular response to cocaine |
| GO_0048265 | Biological process | response to pain |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0043950 | Biological process | positive regulation of cAMP-mediated signaling |
| GO_0030325 | Biological process | adrenal gland development |
| GO_2000854 | Biological process | positive regulation of corticosterone secretion |
| GO_1904044 | Biological process | response to aldosterone |
| GO_0001963 | Biological process | synaptic transmission, dopaminergic |
| GO_0010841 | Biological process | positive regulation of circadian sleep/wake cycle, wakefulness |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0050801 | Biological process | monoatomic ion homeostasis |
| GO_0014062 | Biological process | regulation of serotonin secretion |
| GO_0045472 | Biological process | response to ether |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0051461 | Biological process | positive regulation of corticotropin secretion |
| GO_0035641 | Biological process | locomotory exploration behavior |
| GO_0016101 | Biological process | diterpenoid metabolic process |
| GO_0051412 | Biological process | response to corticosterone |
| GO_0021854 | Biological process | hypothalamus development |
| GO_0032811 | Biological process | negative regulation of epinephrine secretion |
| GO_0051464 | Biological process | positive regulation of cortisol secretion |
| GO_0007567 | Biological process | parturition |
| GO_0090280 | Biological process | positive regulation of calcium ion import |
| GO_0010700 | Biological process | negative regulation of norepinephrine secretion |
| GO_0042322 | Biological process | negative regulation of circadian sleep/wake cycle, REM sleep |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0043204 | Cellular component | perikaryon |
| GO_0043196 | Cellular component | varicosity |
| GO_0045202 | Cellular component | synapse |
| GO_0017045 | Molecular function | corticotropin-releasing hormone activity |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0051430 | Molecular function | corticotropin-releasing hormone receptor 1 binding |
| GO_0051431 | Molecular function | corticotropin-releasing hormone receptor 2 binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005184 | Molecular function | neuropeptide hormone activity |
| Gene name | CRH |
| Protein name | Corticotropin releasing hormone isoform 2 Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) Corticoliberin (Corticotropin-releasing factor) (Corticotropin-releasing hormone) |
| Synonyms | |
| Description | FUNCTION: Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). . |
| Accessions | ENST00000276571.5 A0A0S2Z478 P06850 A0A0S2Z3P5 |
