DOK7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DOK7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DOK7 at tissue level.

III. Associated gene sets

GO_0007528Biological processneuromuscular junction development
GO_0061098Biological processpositive regulation of protein tyrosine kinase activity
GO_0005654Cellular componentnucleoplasm
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding

IV. Literature review

[source]
Gene nameDOK7
Protein nameProtein Dok-7 (Downstream of tyrosine kinase 7)
Docking protein 7
SynonymsC4orf25
DescriptionFUNCTION: Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. .

AccessionsENST00000507039.5 [Q18PE1-4]
A0A1W2PRA3
ENST00000340083.6 [Q18PE1-1]
A0A2R8Y701
Q18PE1
ENST00000643608.1
ENST00000515886.5