Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 35% ± 15% | |
oligodendrocyte precursor cell | 12 studies | 33% ± 18% | |
glutamatergic neuron | 11 studies | 51% ± 21% | |
astrocyte | 11 studies | 38% ± 18% | |
GABAergic neuron | 10 studies | 42% ± 19% | |
microglial cell | 10 studies | 30% ± 15% | |
adipocyte | 8 studies | 28% ± 8% | |
oligodendrocyte | 8 studies | 33% ± 15% | |
fibroblast | 7 studies | 28% ± 10% | |
mast cell | 7 studies | 22% ± 3% | |
interneuron | 6 studies | 53% ± 26% | |
macrophage | 6 studies | 30% ± 10% | |
neuron | 5 studies | 36% ± 14% | |
retinal cone cell | 5 studies | 56% ± 24% | |
cardiac muscle cell | 5 studies | 38% ± 11% | |
endothelial cell of lymphatic vessel | 5 studies | 27% ± 6% | |
pericyte | 5 studies | 26% ± 7% | |
smooth muscle cell | 5 studies | 25% ± 5% | |
type I pneumocyte | 5 studies | 24% ± 8% | |
epithelial cell | 4 studies | 24% ± 11% | |
granule cell | 4 studies | 30% ± 5% | |
GABAergic interneuron | 3 studies | 36% ± 9% | |
progenitor cell | 3 studies | 39% ± 7% | |
Mueller cell | 3 studies | 22% ± 5% | |
retina horizontal cell | 3 studies | 27% ± 5% | |
retinal ganglion cell | 3 studies | 29% ± 7% | |
retinal pigment epithelial cell | 3 studies | 29% ± 14% | |
monocyte | 3 studies | 19% ± 2% | |
type II pneumocyte | 3 studies | 19% ± 3% | |
lymphocyte | 3 studies | 21% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 99% | 277.42 | 242 / 245 | 95% | 1.98 | 477 / 502 |
brain | 91% | 786.06 | 2416 / 2642 | 95% | 3.19 | 670 / 705 |
thymus | 99% | 465.29 | 649 / 653 | 86% | 2.27 | 520 / 605 |
adrenal gland | 96% | 262.82 | 248 / 258 | 76% | 1.49 | 175 / 230 |
esophagus | 80% | 180.28 | 1153 / 1445 | 90% | 2.55 | 164 / 183 |
skin | 92% | 354.70 | 1668 / 1809 | 75% | 2.15 | 356 / 472 |
stomach | 96% | 245.06 | 344 / 359 | 69% | 1.63 | 198 / 286 |
uterus | 96% | 181.06 | 164 / 170 | 60% | 1.36 | 277 / 459 |
intestine | 94% | 345.68 | 912 / 966 | 61% | 1.25 | 324 / 527 |
breast | 69% | 144.16 | 316 / 459 | 85% | 2.04 | 955 / 1118 |
bladder | 95% | 361.48 | 20 / 21 | 52% | 0.96 | 262 / 504 |
ovary | 58% | 73.04 | 104 / 180 | 69% | 1.39 | 297 / 430 |
pancreas | 34% | 55.91 | 112 / 328 | 86% | 1.85 | 153 / 178 |
lung | 44% | 56.38 | 256 / 578 | 65% | 1.29 | 748 / 1155 |
blood vessel | 98% | 399.39 | 1312 / 1335 | 0% | 0 | 0 / 0 |
muscle | 97% | 386.93 | 776 / 803 | 0% | 0 | 0 / 0 |
spleen | 84% | 132.33 | 202 / 241 | 0% | 0 | 0 / 0 |
kidney | 36% | 49.52 | 32 / 89 | 48% | 0.73 | 431 / 901 |
eye | 0% | 0 | 0 / 0 | 81% | 3.21 | 65 / 80 |
heart | 78% | 171.43 | 674 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 66% | 1.72 | 19 / 29 |
tonsil | 0% | 0 | 0 / 0 | 60% | 1.02 | 27 / 45 |
peripheral blood | 55% | 298.90 | 513 / 929 | 0% | 0 | 0 / 0 |
adipose | 51% | 82.47 | 609 / 1204 | 0% | 0 | 0 / 0 |
liver | 4% | 4.81 | 9 / 226 | 29% | 0.68 | 118 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0050772 | Biological process | positive regulation of axonogenesis |
GO_0007264 | Biological process | small GTPase-mediated signal transduction |
GO_0090630 | Biological process | activation of GTPase activity |
GO_0043204 | Cellular component | perikaryon |
GO_0030175 | Cellular component | filopodium |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0030027 | Cellular component | lamellipodium |
GO_0045202 | Cellular component | synapse |
GO_0030426 | Cellular component | growth cone |
GO_0016020 | Cellular component | membrane |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005096 | Molecular function | GTPase activator activity |
Gene name | TIAM2 |
Protein name | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) TIAM Rac1 associated GEF 2 |
Synonyms | KIAA2016 STEF |
Description | FUNCTION: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. . |
Accessions | H0YGV1 F5H1M3 E9PMZ8 F5H6W6 E9PKT1 ENST00000543712.5 ENST00000461783.7 [Q8IVF5-1] H7C5V6 ENST00000682666.1 [Q8IVF5-1] ENST00000456877.6 [Q8IVF5-4] F5H6R0 ENST00000528535.5 ENST00000360366.8 [Q8IVF5-5] ENST00000462408.2 ENST00000535231.5 Q8IVF5 ENST00000535583.1 ENST00000538270.5 ENST00000275246.11 [Q8IVF5-3] ENST00000528391.6 ENST00000529824.6 [Q8IVF5-2] |