TIAM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0050772Biological processpositive regulation of axonogenesis
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0090630Biological processactivation of GTPase activity
GO_0043204Cellular componentperikaryon
GO_0030175Cellular componentfilopodium
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0045202Cellular componentsynapse
GO_0030426Cellular componentgrowth cone
GO_0016020Cellular componentmembrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameTIAM2
Protein nameRho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2)
TIAM Rac1 associated GEF 2
SynonymsKIAA2016
STEF
DescriptionFUNCTION: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. .

AccessionsH0YGV1
F5H1M3
E9PMZ8
F5H6W6
E9PKT1
ENST00000543712.5
ENST00000461783.7 [Q8IVF5-1]
H7C5V6
ENST00000682666.1 [Q8IVF5-1]
ENST00000456877.6 [Q8IVF5-4]
F5H6R0
ENST00000528535.5
ENST00000360366.8 [Q8IVF5-5]
ENST00000462408.2
ENST00000535231.5
Q8IVF5
ENST00000535583.1
ENST00000538270.5
ENST00000275246.11 [Q8IVF5-3]
ENST00000528391.6
ENST00000529824.6 [Q8IVF5-2]