GPR37 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007218Biological processneuropeptide signaling pathway
GO_0034614Biological processcellular response to reactive oxygen species
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0042416Biological processdopamine biosynthetic process
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0031987Biological processlocomotion involved in locomotory behavior
GO_0045964Biological processpositive regulation of dopamine metabolic process
GO_0016358Biological processdendrite development
GO_0000151Cellular componentubiquitin ligase complex
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0005783Cellular componentendoplasmic reticulum
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0042277Molecular functionpeptide binding
GO_0031072Molecular functionheat shock protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0030165Molecular functionPDZ domain binding
GO_0008528Molecular functionG protein-coupled peptide receptor activity
GO_0042923Molecular functionneuropeptide binding
GO_0008188Molecular functionneuropeptide receptor activity
GO_0030544Molecular functionHsp70 protein binding
GO_0036505Molecular functionprosaposin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR37
Protein nameProsaposin receptor GPR37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (G-protein coupled receptor 37) (Parkin-associated endothelin receptor-like receptor) (PAELR)
Synonyms
DescriptionFUNCTION: G-protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (By similarity). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade . Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination. Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway. Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination. Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain. In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection. Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (By similarity). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway . .

AccessionsO15354
ENST00000303921.3