PCLO report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904071Biological processpresynaptic active zone assembly
GO_0017157Biological processregulation of exocytosis
GO_0016079Biological processsynaptic vesicle exocytosis
GO_0007010Biological processcytoskeleton organization
GO_0099526Biological processpresynapse to nucleus signaling pathway
GO_0048790Biological processmaintenance of presynaptic active zone structure
GO_0030073Biological processinsulin secretion
GO_0097091Biological processsynaptic vesicle clustering
GO_0035418Biological processprotein localization to synapse
GO_0098978Cellular componentglutamatergic synapse
GO_0005856Cellular componentcytoskeleton
GO_0070062Cellular componentextracellular exosome
GO_0098982Cellular componentGABA-ergic synapse
GO_0048788Cellular componentcytoskeleton of presynaptic active zone
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0030424Cellular componentaxon
GO_0005544Molecular functioncalcium-dependent phospholipid binding
GO_0005522Molecular functionprofilin binding
GO_0098882Molecular functionstructural constituent of presynaptic active zone
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene namePCLO
Protein nameProtein piccolo (Aczonin)
Piccolo presynaptic cytomatrix protein
PCLO protein
Alternative protein PCLO
SynonymsACZ
KIAA0559
DescriptionFUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). .

AccessionsENST00000333891.14 [Q9Y6V0-5]
Q32P40
ENST00000413807.6
E9PE96
H7C261
ENST00000618073.1 [Q9Y6V0-3]
Q9Y6V0
ENST00000423517.6 [Q9Y6V0-6]
ENST00000437081.1
L8E9M5
H7C114
ENST00000456006.2