Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 13 studies | 76% ± 19% | |
GABAergic neuron | 10 studies | 67% ± 24% | |
oligodendrocyte precursor cell | 10 studies | 29% ± 10% | |
neuron | 8 studies | 48% ± 15% | |
amacrine cell | 8 studies | 67% ± 14% | |
microglial cell | 8 studies | 30% ± 16% | |
interneuron | 7 studies | 63% ± 27% | |
retinal ganglion cell | 7 studies | 69% ± 16% | |
retinal cone cell | 7 studies | 56% ± 23% | |
astrocyte | 7 studies | 33% ± 21% | |
retina horizontal cell | 6 studies | 45% ± 19% | |
retinal rod cell | 6 studies | 35% ± 15% | |
oligodendrocyte | 6 studies | 31% ± 18% | |
endothelial cell | 5 studies | 43% ± 22% | |
retinal bipolar neuron | 5 studies | 43% ± 17% | |
type II pneumocyte | 5 studies | 19% ± 2% | |
epithelial cell | 4 studies | 35% ± 10% | |
granule cell | 4 studies | 78% ± 12% | |
GABAergic amacrine cell | 4 studies | 65% ± 28% | |
endothelial cell of lymphatic vessel | 4 studies | 24% ± 5% | |
OFF-bipolar cell | 4 studies | 54% ± 13% | |
ON-bipolar cell | 4 studies | 57% ± 11% | |
adipocyte | 4 studies | 28% ± 8% | |
enteroendocrine cell | 4 studies | 42% ± 17% | |
type I pneumocyte | 4 studies | 17% ± 3% | |
GABAergic interneuron | 3 studies | 83% ± 0% | |
glycinergic amacrine cell | 3 studies | 62% ± 7% | |
rod bipolar cell | 3 studies | 53% ± 13% | |
retinal pigment epithelial cell | 3 studies | 43% ± 12% | |
goblet cell | 3 studies | 26% ± 12% | |
brush cell | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 93% | 1118.02 | 227 / 245 | 91% | 3.00 | 458 / 502 |
adrenal gland | 93% | 1092.20 | 239 / 258 | 83% | 12.10 | 191 / 230 |
kidney | 98% | 1267.55 | 87 / 89 | 77% | 2.58 | 698 / 901 |
thymus | 99% | 1712.71 | 646 / 653 | 73% | 1.79 | 443 / 605 |
pancreas | 94% | 690.84 | 308 / 328 | 64% | 1.95 | 114 / 178 |
brain | 98% | 5849.17 | 2576 / 2642 | 56% | 2.57 | 395 / 705 |
breast | 65% | 601.18 | 297 / 459 | 81% | 3.25 | 900 / 1118 |
esophagus | 50% | 333.16 | 729 / 1445 | 58% | 3.20 | 107 / 183 |
stomach | 59% | 299.53 | 211 / 359 | 41% | 1.12 | 118 / 286 |
skin | 61% | 441.56 | 1095 / 1809 | 34% | 1.57 | 162 / 472 |
intestine | 48% | 346.58 | 465 / 966 | 44% | 1.23 | 231 / 527 |
lung | 35% | 194.93 | 205 / 578 | 55% | 1.88 | 641 / 1155 |
bladder | 33% | 201.76 | 7 / 21 | 38% | 0.87 | 193 / 504 |
ovary | 38% | 189.17 | 68 / 180 | 32% | 0.59 | 136 / 430 |
tonsil | 0% | 0 | 0 / 0 | 67% | 2.18 | 30 / 45 |
uterus | 15% | 83.09 | 25 / 170 | 51% | 1.50 | 236 / 459 |
eye | 0% | 0 | 0 / 0 | 48% | 1.14 | 38 / 80 |
heart | 42% | 230.38 | 364 / 861 | 0% | 0 | 0 / 0 |
adipose | 25% | 149.81 | 306 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 19% | 108.69 | 247 / 1335 | 0% | 0 | 0 / 0 |
spleen | 12% | 56.07 | 30 / 241 | 0% | 0 | 0 / 0 |
liver | 0% | 0 | 0 / 226 | 11% | 0.28 | 44 / 406 |
muscle | 2% | 11.15 | 13 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1904071 | Biological process | presynaptic active zone assembly |
GO_0017157 | Biological process | regulation of exocytosis |
GO_0016079 | Biological process | synaptic vesicle exocytosis |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0099526 | Biological process | presynapse to nucleus signaling pathway |
GO_0048790 | Biological process | maintenance of presynaptic active zone structure |
GO_0030073 | Biological process | insulin secretion |
GO_0097091 | Biological process | synaptic vesicle clustering |
GO_0035418 | Biological process | protein localization to synapse |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005856 | Cellular component | cytoskeleton |
GO_0070062 | Cellular component | extracellular exosome |
GO_0098982 | Cellular component | GABA-ergic synapse |
GO_0048788 | Cellular component | cytoskeleton of presynaptic active zone |
GO_0045202 | Cellular component | synapse |
GO_0014069 | Cellular component | postsynaptic density |
GO_0030424 | Cellular component | axon |
GO_0005544 | Molecular function | calcium-dependent phospholipid binding |
GO_0005522 | Molecular function | profilin binding |
GO_0098882 | Molecular function | structural constituent of presynaptic active zone |
GO_0005509 | Molecular function | calcium ion binding |
Gene name | PCLO |
Protein name | Protein piccolo (Aczonin) Piccolo presynaptic cytomatrix protein PCLO protein Alternative protein PCLO |
Synonyms | ACZ KIAA0559 |
Description | FUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). . |
Accessions | ENST00000333891.14 [Q9Y6V0-5] Q32P40 ENST00000413807.6 E9PE96 H7C261 ENST00000618073.1 [Q9Y6V0-3] Q9Y6V0 ENST00000423517.6 [Q9Y6V0-6] ENST00000437081.1 L8E9M5 H7C114 ENST00000456006.2 |