SORBS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007219Biological processNotch signaling pathway
GO_0061049Biological processcell growth involved in cardiac muscle cell development
GO_0007010Biological processcytoskeleton organization
GO_0008150Biological processbiological_process
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030018Cellular componentZ disc
GO_0043025Cellular componentneuronal cell body
GO_0005925Cellular componentfocal adhesion
GO_0030425Cellular componentdendrite
GO_0015629Cellular componentactin cytoskeleton
GO_0045202Cellular componentsynapse
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0008307Molecular functionstructural constituent of muscle
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0003723Molecular functionRNA binding
GO_0008093Molecular functioncytoskeletal anchor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSORBS2
Protein nameSorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin)
Sorbin and SH3 domain-containing protein 2
Sorbin and SH3 domain containing 2
SynonymsARGBP2
KIAA0777
DescriptionFUNCTION: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 . Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. .

AccessionsENST00000695410.1
ENST00000698537.1
A0A8V8TMC7
ENST00000445343.5
ENST00000487836.6 [O94875-7]
C9JM25
O94875
ENST00000414724.5
C9J8E3
ENST00000698536.1
C9JEA9
ENST00000355634.9 [O94875-11]
C9JFS9
C9JZ60
ENST00000393523.6
ENST00000487184.2
ENST00000490562.6
A0A8Q3WKK4
ENST00000445625.1
ENST00000452351.5
A0A3B3ITL8
ENST00000444771.5
ENST00000428330.5
C9JN77
ENST00000421420.6
ENST00000451974.6 [O94875-8]
C9JC90
ENST00000415274.5
ENST00000498125.6
C9IZ89
ENST00000432655.5
A0A8Q3WKF2
ENST00000695409.1
ENST00000439049.5
ENST00000451958.5
ENST00000438278.5
A0A8V8TLU4
ENST00000698843.1
C9J9D3
C9J4Z9
ENST00000698540.1
H7BXR3
A0A8Q3SHW0
C9J348
ENST00000319471.13 [O94875-12]
A0A8V8TNN1
C9J620
ENST00000319454.10
ENST00000650145.1
C9J3W4
A0A8V8TNC1
ENST00000419063.5
ENST00000284776.11 [O94875-1]
ENST00000457247.5
H7BZX1
ENST00000393528.7 [O94875-2]
C9JWC3
ENST00000437304.6 [O94875-10]
C9JBR8
ENST00000450341.5
C9JLD6
ENST00000451974.5
ENST00000451701.5
C9J7Q5
C9IZT7
ENST00000695411.1
ENST00000439914.5
ENST00000456596.5
ENST00000420158.5
A0A8Q3WLK0
H7C1R7
A0A8V8TMD6
ENST00000421639.5
ENST00000425679.5
C9JDX2
C9JBB0
A0A8Q3WKH1
A0A9L9PXP6
C9JI79
A0A1D5RMN3
ENST00000429056.5
ENST00000430503.5
C9JL62
ENST00000449407.6 [O94875-9]
H7BZK1
ENST00000457934.5
C9JG84
C9J4K2
ENST00000444781.5
A0A8Q3WLU7
ENST00000456060.5
ENST00000698539.1
ENST00000706921.1
ENST00000435480.5
ENST00000445115.5
C9J372
ENST00000431902.5