I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 11 studies | 30% ± 9% | |
| microglial cell | 9 studies | 42% ± 18% | |
| myeloid cell | 5 studies | 26% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 11 studies | 30% ± 9% | |
| microglial cell | 9 studies | 42% ± 18% | |
| myeloid cell | 5 studies | 26% ± 11% |
Insufficient scRNA-seq data for expression of ADORA3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 80% | 284.93 | 2123 / 2642 | 99% | 28.75 | 698 / 705 |
| breast | 83% | 188.75 | 383 / 459 | 91% | 7.67 | 1012 / 1118 |
| adrenal gland | 99% | 601.05 | 256 / 258 | 55% | 3.05 | 126 / 230 |
| lung | 78% | 274.13 | 451 / 578 | 62% | 3.54 | 719 / 1155 |
| bladder | 100% | 290.90 | 21 / 21 | 39% | 2.12 | 196 / 504 |
| kidney | 52% | 98.03 | 46 / 89 | 86% | 10.81 | 777 / 901 |
| ovary | 62% | 103.96 | 111 / 180 | 74% | 4.95 | 320 / 430 |
| pancreas | 56% | 70.68 | 185 / 328 | 78% | 5.69 | 138 / 178 |
| uterus | 77% | 117.72 | 131 / 170 | 50% | 2.52 | 229 / 459 |
| thymus | 65% | 105.71 | 427 / 653 | 60% | 3.34 | 362 / 605 |
| intestine | 95% | 310.78 | 922 / 966 | 27% | 1.24 | 142 / 527 |
| prostate | 87% | 192.61 | 212 / 245 | 36% | 1.26 | 179 / 502 |
| stomach | 81% | 143.14 | 290 / 359 | 39% | 1.89 | 112 / 286 |
| esophagus | 80% | 161.59 | 1151 / 1445 | 22% | 0.96 | 40 / 183 |
| skin | 30% | 33.01 | 541 / 1809 | 69% | 4.17 | 324 / 472 |
| adipose | 90% | 299.42 | 1088 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 89% | 328.73 | 214 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 85% | 204.23 | 1131 / 1335 | 0% | 0 | 0 / 0 |
| heart | 67% | 131.05 | 580 / 861 | 0% | 0 | 0 / 0 |
| liver | 40% | 62.63 | 90 / 226 | 27% | 1.39 | 110 / 406 |
| peripheral blood | 63% | 165.31 | 589 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 1.90 | 15 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 49% | 2.19 | 22 / 45 |
| eye | 0% | 0 | 0 / 0 | 36% | 1.71 | 29 / 80 |
| muscle | 15% | 13.47 | 121 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0014061 | Biological process | regulation of norepinephrine secretion |
| GO_0001973 | Biological process | G protein-coupled adenosine receptor signaling pathway |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0007190 | Biological process | activation of adenylate cyclase activity |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0009611 | Biological process | response to wounding |
| GO_0008016 | Biological process | regulation of heart contraction |
| GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
| GO_0032088 | Biological process | negative regulation of NF-kappaB transcription factor activity |
| GO_0045202 | Cellular component | synapse |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0001609 | Molecular function | G protein-coupled adenosine receptor activity |
| Gene name | ADORA3 |
| Protein name | Adenosine A3 receptor Adenosine receptor A3 |
| Synonyms | |
| Description | FUNCTION: [Isoform 2]: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase . . |
| Accessions | ENST00000241356.5 [P0DMS8-1] P0DMS8 A0A0J9YWR0 ENST00000632535.1 |
