GIT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0036465Biological processsynaptic vesicle recycling
GO_0048013Biological processephrin receptor signaling pathway
GO_0001957Biological processintramembranous ossification
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0045820Biological processnegative regulation of glycolytic process
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0032012Biological processregulation of ARF protein signal transduction
GO_0090063Biological processpositive regulation of microtubule nucleation
GO_0048666Biological processneuron development
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0007420Biological processbrain development
GO_0106015Biological processnegative regulation of inflammatory response to wounding
GO_0061743Biological processmotor learning
GO_0007626Biological processlocomotory behavior
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0032465Biological processregulation of cytokinesis
GO_0097431Cellular componentmitotic spindle pole
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0098794Cellular componentpostsynapse
GO_0043005Cellular componentneuron projection
GO_0005925Cellular componentfocal adhesion
GO_0044305Cellular componentcalyx of Held
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0030027Cellular componentlamellipodium
GO_0043015Molecular functiongamma-tubulin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGIT1
Protein nameAlternative protein GIT1
GIT ArfGAP 1
GIT1 protein
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Synonyms
DescriptionFUNCTION: GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase . Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 . May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 . May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration . Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation . In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation . May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization . May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors . Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis . .

AccessionsE7EVC2
J3QLH1
Q6PIN6
A0A0C4DGN6
ENST00000578670.5
ENST00000577466.2
J3QQI0
K7EIX6
ENST00000579937.5
L0R865
Q9Y2X7
ENST00000225394.8 [Q9Y2X7-1]
ENST00000394869.7 [Q9Y2X7-3]
Q9BSI3
ENST00000581348.5
J3QL89
ENST00000578266.1
ENST00000335356.7
K7EN79
J3QRU8
ENST00000585148.1
ENST00000583413.4