Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 13 studies | 67% ± 25% | |
| GABAergic neuron | 9 studies | 66% ± 23% | |
| interneuron | 6 studies | 56% ± 30% | |
| neuron | 4 studies | 42% ± 25% | |
| endothelial cell | 4 studies | 41% ± 21% | |
| granule cell | 4 studies | 61% ± 26% | |
| oligodendrocyte precursor cell | 4 studies | 23% ± 4% | |
| retinal ganglion cell | 4 studies | 38% ± 5% | |
| glycinergic amacrine cell | 3 studies | 34% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 16 studies | 41% ± 26% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 91% | 5677.10 | 2409 / 2642 | 51% | 4.68 | 357 / 705 |
| thymus | 2% | 9.58 | 16 / 653 | 71% | 18.30 | 432 / 605 |
| spleen | 68% | 623.17 | 164 / 241 | 0% | 0 | 0 / 0 |
| adrenal gland | 59% | 316.12 | 152 / 258 | 6% | 0.17 | 14 / 230 |
| lung | 28% | 113.55 | 163 / 578 | 9% | 0.33 | 101 / 1155 |
| adipose | 24% | 112.80 | 283 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.37 | 5 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.26 | 6 / 45 |
| intestine | 1% | 2.17 | 6 / 966 | 12% | 0.34 | 64 / 527 |
| breast | 4% | 13.94 | 18 / 459 | 8% | 0.16 | 94 / 1118 |
| stomach | 1% | 6.08 | 3 / 359 | 9% | 0.25 | 27 / 286 |
| esophagus | 3% | 11.60 | 38 / 1445 | 7% | 0.24 | 13 / 183 |
| ovary | 1% | 3.39 | 2 / 180 | 8% | 0.20 | 34 / 430 |
| kidney | 6% | 18.61 | 5 / 89 | 3% | 0.11 | 29 / 901 |
| uterus | 1% | 3.75 | 2 / 170 | 7% | 0.16 | 31 / 459 |
| bladder | 0% | 0 | 0 / 21 | 5% | 0.14 | 26 / 504 |
| skin | 0% | 0.79 | 5 / 1809 | 3% | 0.11 | 16 / 472 |
| peripheral blood | 3% | 16.48 | 24 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 2% | 0.04 | 4 / 178 |
| heart | 1% | 5.47 | 11 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| blood vessel | 1% | 3.67 | 12 / 1335 | 0% | 0 | 0 / 0 |
| prostate | 0% | 1.03 | 1 / 245 | 0% | 0.01 | 2 / 502 |
| muscle | 0% | 1.03 | 3 / 803 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 0% | 0.00 | 1 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071420 | Biological process | cellular response to histamine |
| GO_0042391 | Biological process | regulation of membrane potential |
| GO_1904862 | Biological process | inhibitory synapse assembly |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0090102 | Biological process | cochlea development |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0060119 | Biological process | inner ear receptor cell development |
| GO_0051932 | Biological process | synaptic transmission, GABAergic |
| GO_0007214 | Biological process | gamma-aminobutyric acid signaling pathway |
| GO_0060384 | Biological process | innervation |
| GO_0005886 | Cellular component | plasma membrane |
| GO_1902495 | Cellular component | transmembrane transporter complex |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0043005 | Cellular component | neuron projection |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0045202 | Cellular component | synapse |
| GO_1902711 | Cellular component | GABA-A receptor complex |
| GO_0099634 | Cellular component | postsynaptic specialization membrane |
| GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
| GO_0016917 | Molecular function | GABA receptor activity |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0004890 | Molecular function | GABA-A receptor activity |
| GO_0030594 | Molecular function | neurotransmitter receptor activity |
| GO_0022851 | Molecular function | GABA-gated chloride ion channel activity |
| GO_0005254 | Molecular function | chloride channel activity |
| Gene name | GABRB2 |
| Protein name | Gamma-aminobutyric acid type A receptor subunit beta2 Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) Gamma-aminobutyric acid A receptor beta 2 |
| Synonyms | |
| Description | FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity . Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). . |
| Accessions | ENST00000675746.1 P47870 A0A6Q8PGD9 E7EV50 ENST00000675773.1 [P47870-1] D1M715 D1M744 ENST00000675081.1 ENST00000517547.5 ENST00000274547.7 [P47870-2] B7Z279 A0A6Q8PGT5 ENST00000520240.5 [P47870-1] ENST00000675381.1 ENST00000393959.6 [P47870-2] ENST00000353437.10 [P47870-1] ENST00000675303.1 [P47870-1] A0A6Q8PFU0 ENST00000517901.5 |
