GLS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	36% ± 15%	Explore
B cell	20 studies	28% ± 11%	Explore
macrophage	20 studies	32% ± 15%	Explore
fibroblast	19 studies	31% ± 9%	Explore
endothelial cell of lymphatic vessel	15 studies	39% ± 18%	Explore
pericyte	15 studies	31% ± 11%	Explore
natural killer cell	14 studies	28% ± 12%	Explore
smooth muscle cell	14 studies	32% ± 12%	Explore
T cell	13 studies	32% ± 16%	Explore
glutamatergic neuron	13 studies	61% ± 26%	Explore
type I pneumocyte	12 studies	45% ± 20%	Explore
oligodendrocyte precursor cell	12 studies	35% ± 14%	Explore
microglial cell	12 studies	44% ± 12%	Explore
GABAergic neuron	11 studies	50% ± 25%	Explore
CD4-positive, alpha-beta T cell	11 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	11 studies	26% ± 7%	Explore
oligodendrocyte	11 studies	31% ± 10%	Explore
dendritic cell	10 studies	39% ± 12%	Explore
type II pneumocyte	10 studies	42% ± 15%	Explore
epithelial cell	10 studies	42% ± 16%	Explore
astrocyte	10 studies	27% ± 12%	Explore
mast cell	9 studies	28% ± 7%	Explore
epithelial cell of proximal tubule	9 studies	42% ± 11%	Explore
monocyte	8 studies	27% ± 5%	Explore
plasma cell	8 studies	35% ± 14%	Explore
myeloid cell	8 studies	28% ± 6%	Explore
regulatory T cell	8 studies	29% ± 10%	Explore
leukocyte	7 studies	34% ± 11%	Explore
conventional dendritic cell	7 studies	25% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	32% ± 8%	Explore
memory B cell	7 studies	20% ± 6%	Explore
retinal ganglion cell	7 studies	58% ± 21%	Explore
retinal cone cell	7 studies	41% ± 15%	Explore
mesothelial cell	7 studies	45% ± 16%	Explore
naive B cell	6 studies	24% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	25% ± 8%	Explore
mature NK T cell	6 studies	28% ± 8%	Explore
capillary endothelial cell	6 studies	22% ± 5%	Explore
neuron	6 studies	38% ± 12%	Explore
enterocyte	6 studies	24% ± 6%	Explore
amacrine cell	6 studies	22% ± 10%	Explore
interneuron	6 studies	54% ± 29%	Explore
adipocyte	6 studies	27% ± 8%	Explore
endothelial cell of artery	6 studies	21% ± 6%	Explore
vein endothelial cell	6 studies	34% ± 22%	Explore
gamma-delta T cell	6 studies	29% ± 11%	Explore
endothelial cell of vascular tree	6 studies	30% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	30% ± 4%	Explore
non-classical monocyte	5 studies	24% ± 8%	Explore
mononuclear phagocyte	5 studies	26% ± 10%	Explore
retinal bipolar neuron	5 studies	25% ± 8%	Explore
renal principal cell	5 studies	54% ± 15%	Explore
mucosal invariant T cell	5 studies	28% ± 6%	Explore
lymphocyte	5 studies	43% ± 16%	Explore
retinal rod cell	5 studies	37% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	29% ± 10%	Explore
plasmacytoid dendritic cell	5 studies	23% ± 4%	Explore
pancreatic A cell	4 studies	53% ± 28%	Explore
classical monocyte	4 studies	27% ± 6%	Explore
plasmablast	4 studies	34% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	44% ± 17%	Explore
progenitor cell	4 studies	22% ± 3%	Explore
granule cell	4 studies	45% ± 17%	Explore
kidney loop of Henle epithelial cell	4 studies	23% ± 4%	Explore
cardiac muscle cell	4 studies	19% ± 2%	Explore
ON-bipolar cell	4 studies	48% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	22% ± 5%	Explore
basal cell	4 studies	41% ± 27%	Explore
connective tissue cell	4 studies	23% ± 4%	Explore
club cell	4 studies	33% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	24% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	25% ± 8%	Explore
GABAergic interneuron	3 studies	51% ± 11%	Explore
glial cell	3 studies	18% ± 1%	Explore
precursor B cell	3 studies	22% ± 7%	Explore
ciliated cell	3 studies	25% ± 6%	Explore
GABAergic amacrine cell	3 studies	39% ± 18%	Explore
OFF-bipolar cell	3 studies	36% ± 9%	Explore
rod bipolar cell	3 studies	49% ± 19%	Explore
CD4-positive helper T cell	3 studies	34% ± 12%	Explore
muscle cell	3 studies	41% ± 30%	Explore
enteroendocrine cell	3 studies	23% ± 3%	Explore
goblet cell	3 studies	33% ± 18%	Explore
intestinal crypt stem cell	3 studies	18% ± 1%	Explore
myofibroblast cell	3 studies	27% ± 8%	Explore
podocyte	3 studies	64% ± 16%	Explore
renal alpha-intercalated cell	3 studies	30% ± 9%	Explore
mural cell	3 studies	35% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	41% ± 22%	Explore
lung	9 studies	30% ± 11%	Explore
eye	9 studies	31% ± 17%	Explore
kidney	7 studies	34% ± 13%	Explore
peripheral blood	4 studies	31% ± 9%	Explore
heart	4 studies	23% ± 5%	Explore
uterus	4 studies	22% ± 6%	Explore
intestine	4 studies	24% ± 6%	Explore
liver	4 studies	22% ± 7%	Explore
pancreas	3 studies	42% ± 20%	Explore
adipose	3 studies	36% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	18121.61	89 / 89	99%	82.99	896 / 901
thymus	100%	7453.30	653 / 653	99%	43.32	600 / 605
lung	100%	8853.81	577 / 578	99%	48.76	1142 / 1155
pancreas	100%	3886.37	327 / 328	98%	31.73	174 / 178
esophagus	96%	4395.62	1392 / 1445	99%	45.46	182 / 183
intestine	100%	5532.08	966 / 966	94%	31.94	498 / 527
breast	100%	5067.30	458 / 459	95%	26.16	1058 / 1118
adrenal gland	100%	14497.84	258 / 258	94%	25.66	217 / 230
skin	99%	7042.25	1796 / 1809	94%	39.30	442 / 472
brain	95%	8548.68	2510 / 2642	96%	20.95	680 / 705
bladder	100%	5150.33	21 / 21	91%	26.61	460 / 504
uterus	100%	6080.97	170 / 170	91%	21.44	417 / 459
prostate	99%	3758.42	243 / 245	86%	14.06	433 / 502
stomach	86%	2706.75	308 / 359	96%	32.32	275 / 286
ovary	100%	4953.96	180 / 180	81%	11.57	347 / 430
blood vessel	100%	14212.36	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	51.36	29 / 29
spleen	100%	7964.10	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	12.46	1 / 1
adipose	100%	7156.66	1203 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	19.67	42 / 45
heart	92%	3524.21	795 / 861	0%	0	0 / 0
liver	17%	339.39	38 / 226	51%	11.44	208 / 406
muscle	60%	1256.61	485 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	60%	13.38	48 / 80
peripheral blood	58%	4622.96	542 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0090461	Biological process	intracellular glutamate homeostasis
GO_0001967	Biological process	suckling behavior
GO_0002087	Biological process	regulation of respiratory gaseous exchange by nervous system process
GO_0006543	Biological process	glutamine catabolic process
GO_0006537	Biological process	glutamate biosynthetic process
GO_0007268	Biological process	chemical synaptic transmission
GO_0051289	Biological process	protein homotetramerization
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0004359	Molecular function	glutaminase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GLS
Protein name	glutaminase (EC 3.5.1.2) Uncharacterized protein GLS Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain] Glutaminase
Synonyms	KIAA0838 GLS1
Description	FUNCTION: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain . .; FUNCTION: [Isoform 2]: Lacks catalytic activity. .
Accessions	B8ZZC5 ENST00000409428.5 H7BZD1 ENST00000417154.6 ENST00000409215.5 Q53RX0 ENST00000320717.8 [O94925-1] ENST00000471443.1 H7C201 A0A994J3S8 ENST00000706565.1 ENST00000338435.9 [O94925-3] A0A9L9PXA4 Q53TX0 O94925 Q53S89 ENST00000412247.2 B7Z509

GLS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review