CPEB4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042149Biological processcellular response to glucose starvation
GO_0002931Biological processresponse to ischemia
GO_0006412Biological processtranslation
GO_0035235Biological processionotropic glutamate receptor signaling pathway
GO_2000766Biological processnegative regulation of cytoplasmic translation
GO_0036294Biological processcellular response to decreased oxygen levels
GO_0071230Biological processcellular response to amino acid stimulus
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0005783Cellular componentendoplasmic reticulum
GO_0045202Cellular componentsynapse
GO_0030426Cellular componentgrowth cone
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_1990124Cellular componentmessenger ribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0043022Molecular functionribosome binding
GO_0000900Molecular functionmRNA regulatory element binding translation repressor activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCPEB4
Protein nameCytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4)
Cytoplasmic polyadenylation element binding protein 4
CPEB4 protein (Cytoplasmic polyadenylation element binding protein 4)
SynonymsKIAA1673
DescriptionFUNCTION: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR . RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism . Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation . Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT . Stimulates proliferation of melanocytes . In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). .

AccessionsE5RJM0
B7ZLQ8
A0A590UJN2
ENST00000656232.1
ENST00000520867.5
A0A590UJI5
ENST00000265085.10 [Q17RY0-1]
ENST00000659882.1
H0YBG1
A0A590UK96
E5RFP2
ENST00000519835.5
ENST00000334035.9 [Q17RY0-2]
ENST00000519467.1
ENST00000519152.5
Q17RY0
ENST00000522336.5
ENST00000517880.1 [Q17RY0-3]
ENST00000657000.1