Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 26 studies | 29% ± 13% | |
endothelial cell | 25 studies | 32% ± 14% | |
astrocyte | 21 studies | 50% ± 19% | |
mast cell | 20 studies | 36% ± 13% | |
oligodendrocyte | 16 studies | 41% ± 13% | |
oligodendrocyte precursor cell | 16 studies | 57% ± 21% | |
microglial cell | 14 studies | 35% ± 11% | |
ciliated cell | 13 studies | 28% ± 12% | |
glutamatergic neuron | 13 studies | 54% ± 25% | |
plasma cell | 12 studies | 36% ± 17% | |
monocyte | 10 studies | 29% ± 9% | |
GABAergic neuron | 10 studies | 51% ± 21% | |
type I pneumocyte | 9 studies | 30% ± 7% | |
myeloid cell | 9 studies | 35% ± 9% | |
adipocyte | 9 studies | 36% ± 10% | |
endothelial cell of lymphatic vessel | 8 studies | 28% ± 11% | |
pericyte | 8 studies | 24% ± 9% | |
epithelial cell | 8 studies | 39% ± 20% | |
classical monocyte | 7 studies | 27% ± 9% | |
neuron | 7 studies | 45% ± 14% | |
retinal cone cell | 7 studies | 32% ± 10% | |
smooth muscle cell | 6 studies | 23% ± 10% | |
capillary endothelial cell | 6 studies | 20% ± 3% | |
kidney loop of Henle epithelial cell | 6 studies | 24% ± 8% | |
amacrine cell | 6 studies | 37% ± 19% | |
interneuron | 6 studies | 54% ± 22% | |
retinal ganglion cell | 6 studies | 47% ± 17% | |
club cell | 6 studies | 28% ± 9% | |
retina horizontal cell | 6 studies | 41% ± 11% | |
retinal rod cell | 6 studies | 27% ± 6% | |
cardiac muscle cell | 6 studies | 64% ± 24% | |
Mueller cell | 6 studies | 42% ± 9% | |
neutrophil | 5 studies | 19% ± 5% | |
non-classical monocyte | 5 studies | 28% ± 9% | |
epithelial cell of proximal tubule | 5 studies | 23% ± 5% | |
retinal bipolar neuron | 5 studies | 35% ± 6% | |
retinal pigment epithelial cell | 5 studies | 68% ± 16% | |
dendritic cell | 5 studies | 23% ± 7% | |
hepatocyte | 5 studies | 59% ± 25% | |
erythrocyte | 5 studies | 46% ± 22% | |
type II pneumocyte | 5 studies | 19% ± 3% | |
squamous epithelial cell | 4 studies | 50% ± 13% | |
granule cell | 4 studies | 44% ± 12% | |
kidney distal convoluted tubule epithelial cell | 4 studies | 65% ± 13% | |
renal alpha-intercalated cell | 4 studies | 46% ± 11% | |
basal cell | 4 studies | 25% ± 8% | |
lymphocyte | 4 studies | 24% ± 8% | |
ON-bipolar cell | 4 studies | 40% ± 12% | |
endothelial cell of vascular tree | 4 studies | 31% ± 13% | |
fibroblast | 4 studies | 27% ± 9% | |
T cell | 3 studies | 18% ± 2% | |
ionocyte | 3 studies | 24% ± 6% | |
conventional dendritic cell | 3 studies | 20% ± 5% | |
glomerular endothelial cell | 3 studies | 36% ± 9% | |
IgG plasma cell | 3 studies | 28% ± 4% | |
GABAergic interneuron | 3 studies | 41% ± 8% | |
mononuclear phagocyte | 3 studies | 25% ± 11% | |
OFF-bipolar cell | 3 studies | 41% ± 11% | |
glycinergic amacrine cell | 3 studies | 32% ± 11% | |
rod bipolar cell | 3 studies | 52% ± 9% | |
respiratory goblet cell | 3 studies | 30% ± 11% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 23% ± 3% | |
granulocyte | 3 studies | 22% ± 5% | |
muscle cell | 3 studies | 41% ± 32% | |
pancreatic A cell | 3 studies | 42% ± 12% | |
ependymal cell | 3 studies | 39% ± 28% | |
enteroendocrine cell | 3 studies | 23% ± 4% | |
alveolar macrophage | 3 studies | 40% ± 11% | |
melanocyte | 3 studies | 51% ± 23% | |
podocyte | 3 studies | 57% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 14585.98 | 258 / 258 | 100% | 44.87 | 230 / 230 |
brain | 100% | 4640.38 | 2638 / 2642 | 99% | 32.21 | 701 / 705 |
esophagus | 100% | 3147.55 | 1441 / 1445 | 98% | 16.29 | 179 / 183 |
lung | 100% | 4374.64 | 576 / 578 | 96% | 12.83 | 1114 / 1155 |
kidney | 100% | 4118.78 | 89 / 89 | 96% | 25.50 | 865 / 901 |
breast | 100% | 3490.94 | 459 / 459 | 95% | 20.29 | 1060 / 1118 |
liver | 100% | 2924.40 | 226 / 226 | 92% | 15.04 | 375 / 406 |
pancreas | 99% | 2624.16 | 325 / 328 | 93% | 12.53 | 166 / 178 |
prostate | 99% | 2161.66 | 242 / 245 | 92% | 12.16 | 463 / 502 |
thymus | 100% | 4738.26 | 653 / 653 | 91% | 16.83 | 548 / 605 |
skin | 99% | 2922.79 | 1799 / 1809 | 89% | 13.85 | 422 / 472 |
stomach | 99% | 3081.26 | 356 / 359 | 90% | 10.11 | 256 / 286 |
intestine | 100% | 2311.15 | 962 / 966 | 79% | 7.84 | 417 / 527 |
uterus | 100% | 2165.66 | 170 / 170 | 75% | 7.26 | 343 / 459 |
bladder | 100% | 2707.38 | 21 / 21 | 73% | 7.05 | 366 / 504 |
ovary | 97% | 1535.46 | 174 / 180 | 70% | 5.44 | 300 / 430 |
adipose | 100% | 3253.89 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 8962.97 | 803 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3622.57 | 1332 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3126.57 | 240 / 241 | 0% | 0 | 0 / 0 |
heart | 98% | 6126.36 | 848 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 2946.47 | 858 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 84% | 8.35 | 38 / 45 |
eye | 0% | 0 | 0 / 0 | 75% | 11.62 | 60 / 80 |
lymph node | 0% | 0 | 0 / 0 | 66% | 7.81 | 19 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0042149 | Biological process | cellular response to glucose starvation |
GO_0002931 | Biological process | response to ischemia |
GO_0006412 | Biological process | translation |
GO_0035235 | Biological process | ionotropic glutamate receptor signaling pathway |
GO_2000766 | Biological process | negative regulation of cytoplasmic translation |
GO_0036294 | Biological process | cellular response to decreased oxygen levels |
GO_0071230 | Biological process | cellular response to amino acid stimulus |
GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
GO_0043197 | Cellular component | dendritic spine |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0043005 | Cellular component | neuron projection |
GO_0030425 | Cellular component | dendrite |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0045202 | Cellular component | synapse |
GO_0030426 | Cellular component | growth cone |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_1990124 | Cellular component | messenger ribonucleoprotein complex |
GO_0005634 | Cellular component | nucleus |
GO_0008135 | Molecular function | translation factor activity, RNA binding |
GO_0043022 | Molecular function | ribosome binding |
GO_0000900 | Molecular function | mRNA regulatory element binding translation repressor activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0003723 | Molecular function | RNA binding |
GO_0003730 | Molecular function | mRNA 3'-UTR binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CPEB4 |
Protein name | Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4) Cytoplasmic polyadenylation element binding protein 4 CPEB4 protein (Cytoplasmic polyadenylation element binding protein 4) |
Synonyms | KIAA1673 |
Description | FUNCTION: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR . RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism . Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation . Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT . Stimulates proliferation of melanocytes . In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). . |
Accessions | E5RJM0 B7ZLQ8 A0A590UJN2 ENST00000656232.1 ENST00000520867.5 A0A590UJI5 ENST00000265085.10 [Q17RY0-1] ENST00000659882.1 H0YBG1 A0A590UK96 E5RFP2 ENST00000519835.5 ENST00000334035.9 [Q17RY0-2] ENST00000519467.1 ENST00000519152.5 Q17RY0 ENST00000522336.5 ENST00000517880.1 [Q17RY0-3] ENST00000657000.1 |