FZD5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FZD5 at tissue level.

III. Associated gene sets

GO_0002071Biological processglandular epithelial cell maturation
GO_1901524Biological processregulation of mitophagy
GO_0001525Biological processangiogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0002726Biological processpositive regulation of T cell cytokine production
GO_0060718Biological processchorionic trophoblast cell differentiation
GO_0048596Biological processembryonic camera-type eye morphogenesis
GO_1901382Biological processregulation of chorionic trophoblast cell proliferation
GO_0071219Biological processcellular response to molecule of bacterial origin
GO_0008595Biological processanterior/posterior axis specification, embryo
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0033077Biological processT cell differentiation in thymus
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0030182Biological processneuron differentiation
GO_0060561Biological processapoptotic process involved in morphogenesis
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_2000810Biological processregulation of bicellular tight junction assembly
GO_0060716Biological processlabyrinthine layer blood vessel development
GO_0060061Biological processSpemann organizer formation
GO_0060670Biological processbranching involved in labyrinthine layer morphogenesis
GO_0000578Biological processembryonic axis specification
GO_0032729Biological processpositive regulation of type II interferon production
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0007416Biological processsynapse assembly
GO_0060574Biological processintestinal epithelial cell maturation
GO_0060715Biological processsyncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0031077Biological processpost-embryonic camera-type eye development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0043204Cellular componentperikaryon
GO_0031901Cellular componentearly endosome membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0045202Cellular componentsynapse
GO_0005923Cellular componentbicellular tight junction
GO_0030424Cellular componentaxon
GO_0017147Molecular functionWnt-protein binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0008289Molecular functionlipid binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0001540Molecular functionamyloid-beta binding
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042813Molecular functionWnt receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFZD5
Protein nameFrizzled-5 (Fz-5) (hFz5) (FzE5)
SynonymsC2orf31
DescriptionFUNCTION: Receptor for Wnt proteins . Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses . Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). .

AccessionsQ13467
ENST00000295417.4