Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 29 studies | 52% ± 19% | |
astrocyte | 16 studies | 43% ± 18% | |
microglial cell | 15 studies | 47% ± 14% | |
mast cell | 14 studies | 42% ± 15% | |
oligodendrocyte | 14 studies | 41% ± 14% | |
oligodendrocyte precursor cell | 14 studies | 43% ± 18% | |
pericyte | 13 studies | 44% ± 15% | |
glutamatergic neuron | 12 studies | 69% ± 23% | |
macrophage | 12 studies | 36% ± 15% | |
GABAergic neuron | 11 studies | 55% ± 23% | |
fibroblast | 10 studies | 29% ± 7% | |
smooth muscle cell | 10 studies | 37% ± 12% | |
type I pneumocyte | 8 studies | 38% ± 19% | |
epithelial cell | 8 studies | 39% ± 18% | |
neuron | 7 studies | 49% ± 17% | |
adipocyte | 7 studies | 31% ± 7% | |
endothelial cell of lymphatic vessel | 7 studies | 42% ± 12% | |
monocyte | 6 studies | 31% ± 7% | |
interneuron | 6 studies | 65% ± 19% | |
capillary endothelial cell | 6 studies | 37% ± 20% | |
endothelial cell of artery | 6 studies | 35% ± 15% | |
ciliated cell | 6 studies | 35% ± 16% | |
myeloid cell | 5 studies | 25% ± 6% | |
plasma cell | 5 studies | 35% ± 11% | |
cardiac muscle cell | 5 studies | 46% ± 13% | |
dendritic cell | 5 studies | 24% ± 4% | |
type II pneumocyte | 5 studies | 42% ± 7% | |
classical monocyte | 4 studies | 17% ± 3% | |
granule cell | 4 studies | 51% ± 16% | |
club cell | 4 studies | 38% ± 10% | |
mesothelial cell | 4 studies | 43% ± 15% | |
cholangiocyte | 3 studies | 41% ± 18% | |
hematopoietic precursor cell | 3 studies | 32% ± 14% | |
GABAergic interneuron | 3 studies | 58% ± 2% | |
glial cell | 3 studies | 30% ± 12% | |
CD4-positive, alpha-beta T cell | 3 studies | 17% ± 0% | |
vein endothelial cell | 3 studies | 47% ± 22% | |
GABAergic amacrine cell | 3 studies | 37% ± 9% | |
Mueller cell | 3 studies | 66% ± 17% | |
amacrine cell | 3 studies | 30% ± 12% | |
glycinergic amacrine cell | 3 studies | 31% ± 5% | |
retina horizontal cell | 3 studies | 41% ± 15% | |
retinal cone cell | 3 studies | 52% ± 16% | |
retinal rod cell | 3 studies | 45% ± 12% | |
endothelial cell of vascular tree | 3 studies | 58% ± 24% | |
hepatocyte | 3 studies | 56% ± 17% | |
ependymal cell | 3 studies | 55% ± 11% | |
B cell | 3 studies | 25% ± 6% | |
T cell | 3 studies | 24% ± 7% | |
alveolar macrophage | 3 studies | 37% ± 8% | |
erythrocyte | 3 studies | 61% ± 30% | |
respiratory goblet cell | 3 studies | 39% ± 16% | |
lymphocyte | 3 studies | 30% ± 11% | |
basal cell | 3 studies | 45% ± 24% | |
mucus secreting cell | 3 studies | 40% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 4598.05 | 2641 / 2642 | 100% | 23.28 | 703 / 705 |
esophagus | 100% | 2839.26 | 1443 / 1445 | 98% | 10.86 | 180 / 183 |
intestine | 100% | 3652.02 | 966 / 966 | 98% | 10.64 | 515 / 527 |
kidney | 100% | 2637.13 | 89 / 89 | 98% | 18.95 | 879 / 901 |
stomach | 100% | 2962.80 | 359 / 359 | 97% | 11.76 | 277 / 286 |
thymus | 100% | 5382.75 | 653 / 653 | 96% | 14.37 | 581 / 605 |
skin | 100% | 3258.39 | 1809 / 1809 | 96% | 13.55 | 453 / 472 |
breast | 100% | 4432.19 | 459 / 459 | 95% | 10.17 | 1059 / 1118 |
prostate | 100% | 2503.31 | 244 / 245 | 95% | 10.62 | 477 / 502 |
pancreas | 99% | 1880.44 | 326 / 328 | 94% | 9.42 | 168 / 178 |
lung | 100% | 4785.98 | 578 / 578 | 93% | 9.17 | 1077 / 1155 |
adrenal gland | 100% | 1892.75 | 257 / 258 | 93% | 10.69 | 213 / 230 |
bladder | 100% | 2648.48 | 21 / 21 | 88% | 7.17 | 441 / 504 |
liver | 100% | 2301.41 | 226 / 226 | 83% | 7.17 | 337 / 406 |
uterus | 100% | 3170.24 | 170 / 170 | 82% | 5.65 | 375 / 459 |
ovary | 100% | 2255.59 | 180 / 180 | 72% | 4.17 | 311 / 430 |
adipose | 100% | 4637.11 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3773.93 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2397.29 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4556.02 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 100% | 2888.08 | 858 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 10.38 | 78 / 80 |
peripheral blood | 87% | 2732.01 | 807 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 69% | 4.72 | 31 / 45 |
lymph node | 0% | 0 | 0 / 0 | 52% | 4.59 | 15 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007265 | Biological process | Ras protein signal transduction |
GO_0007218 | Biological process | neuropeptide signaling pathway |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0031547 | Biological process | brain-derived neurotrophic factor receptor signaling pathway |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0071880 | Biological process | adenylate cyclase-activating adrenergic receptor signaling pathway |
GO_0010976 | Biological process | positive regulation of neuron projection development |
GO_0000165 | Biological process | MAPK cascade |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0031175 | Biological process | neuron projection development |
GO_0032092 | Biological process | positive regulation of protein binding |
GO_2001224 | Biological process | positive regulation of neuron migration |
GO_2000670 | Biological process | positive regulation of dendritic cell apoptotic process |
GO_1901888 | Biological process | regulation of cell junction assembly |
GO_0019933 | Biological process | cAMP-mediated signaling |
GO_0001764 | Biological process | neuron migration |
GO_0071321 | Biological process | cellular response to cGMP |
GO_0038180 | Biological process | nerve growth factor signaling pathway |
GO_0045860 | Biological process | positive regulation of protein kinase activity |
GO_0030033 | Biological process | microvillus assembly |
GO_0048022 | Biological process | negative regulation of melanin biosynthetic process |
GO_0032486 | Biological process | Rap protein signal transduction |
GO_0021591 | Biological process | ventricular system development |
GO_0048167 | Biological process | regulation of synaptic plasticity |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0071320 | Biological process | cellular response to cAMP |
GO_0035556 | Biological process | intracellular signal transduction |
GO_1990090 | Biological process | cellular response to nerve growth factor stimulus |
GO_0007264 | Biological process | small GTPase-mediated signal transduction |
GO_0001568 | Biological process | blood vessel development |
GO_0021884 | Biological process | forebrain neuron development |
GO_0090557 | Biological process | establishment of endothelial intestinal barrier |
GO_2001214 | Biological process | positive regulation of vasculogenesis |
GO_0061028 | Biological process | establishment of endothelial barrier |
GO_0050774 | Biological process | negative regulation of dendrite morphogenesis |
GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
GO_2000481 | Biological process | positive regulation of cAMP-dependent protein kinase activity |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0030139 | Cellular component | endocytic vesicle |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_0043025 | Cellular component | neuronal cell body |
GO_0043005 | Cellular component | neuron projection |
GO_0005911 | Cellular component | cell-cell junction |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0005770 | Cellular component | late endosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0005923 | Cellular component | bicellular tight junction |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0030552 | Molecular function | cAMP binding |
GO_0030553 | Molecular function | cGMP binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0050699 | Molecular function | WW domain binding |
GO_0030165 | Molecular function | PDZ domain binding |
GO_0031697 | Molecular function | beta-1 adrenergic receptor binding |
GO_0070300 | Molecular function | phosphatidic acid binding |
GO_0005509 | Molecular function | calcium ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0019992 | Molecular function | diacylglycerol binding |
Gene name | RAPGEF2 |
Protein name | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Rap guanine nucleotide exchange factor 2 Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) |
Synonyms | KIAA0313 PDZGEF1 NRAPGEP |
Description | FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not . Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. . |
Accessions | ENST00000691494.1 D6RC78 A0A2R8YGD3 ENST00000510510.5 Q9Y4G8 ENST00000514565.1 ENST00000264431.8 ENST00000644474.1 A0A8I5KZ40 A0A2R8Y661 D6RAK0 ENST00000644902.1 A0A994J7S7 ENST00000505026.2 Q17RH5 |