RAPGEF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0007218Biological processneuropeptide signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0031547Biological processbrain-derived neurotrophic factor receptor signaling pathway
GO_0072659Biological processprotein localization to plasma membrane
GO_0071880Biological processadenylate cyclase-activating adrenergic receptor signaling pathway
GO_0010976Biological processpositive regulation of neuron projection development
GO_0000165Biological processMAPK cascade
GO_0043547Biological processpositive regulation of GTPase activity
GO_0031175Biological processneuron projection development
GO_0032092Biological processpositive regulation of protein binding
GO_2001224Biological processpositive regulation of neuron migration
GO_2000670Biological processpositive regulation of dendritic cell apoptotic process
GO_1901888Biological processregulation of cell junction assembly
GO_0019933Biological processcAMP-mediated signaling
GO_0001764Biological processneuron migration
GO_0071321Biological processcellular response to cGMP
GO_0038180Biological processnerve growth factor signaling pathway
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0030033Biological processmicrovillus assembly
GO_0048022Biological processnegative regulation of melanin biosynthetic process
GO_0032486Biological processRap protein signal transduction
GO_0021591Biological processventricular system development
GO_0048167Biological processregulation of synaptic plasticity
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0071320Biological processcellular response to cAMP
GO_0035556Biological processintracellular signal transduction
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0001568Biological processblood vessel development
GO_0021884Biological processforebrain neuron development
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_2001214Biological processpositive regulation of vasculogenesis
GO_0061028Biological processestablishment of endothelial barrier
GO_0050774Biological processnegative regulation of dendrite morphogenesis
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_2000481Biological processpositive regulation of cAMP-dependent protein kinase activity
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0030139Cellular componentendocytic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0032991Cellular componentprotein-containing complex
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0030552Molecular functioncAMP binding
GO_0030553Molecular functioncGMP binding
GO_0005096Molecular functionGTPase activator activity
GO_0050699Molecular functionWW domain binding
GO_0030165Molecular functionPDZ domain binding
GO_0031697Molecular functionbeta-1 adrenergic receptor binding
GO_0070300Molecular functionphosphatidic acid binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0019992Molecular functiondiacylglycerol binding

IV. Literature review

[source]
Gene nameRAPGEF2
Protein nameRap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
Rap guanine nucleotide exchange factor 2
Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
SynonymsKIAA0313
PDZGEF1
NRAPGEP
DescriptionFUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not . Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. .

AccessionsENST00000691494.1
D6RC78
A0A2R8YGD3
ENST00000510510.5
Q9Y4G8
ENST00000514565.1
ENST00000264431.8
ENST00000644474.1
A0A8I5KZ40
A0A2R8Y661
D6RAK0
ENST00000644902.1
A0A994J7S7
ENST00000505026.2
Q17RH5