EIF3D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902416Biological processpositive regulation of mRNA binding
GO_0001732Biological processformation of cytoplasmic translation initiation complex
GO_0075522Biological processIRES-dependent viral translational initiation
GO_0075525Biological processviral translational termination-reinitiation
GO_0006413Biological processtranslational initiation
GO_0002191Biological processcap-dependent translational initiation
GO_0045727Biological processpositive regulation of translation
GO_0005852Cellular componenteukaryotic translation initiation factor 3 complex
GO_0033290Cellular componenteukaryotic 48S preinitiation complex
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0071541Cellular componenteukaryotic translation initiation factor 3 complex, eIF3m
GO_0016282Cellular componenteukaryotic 43S preinitiation complex
GO_0016020Cellular componentmembrane
GO_0003743Molecular functiontranslation initiation factor activity
GO_0005515Molecular functionprotein binding
GO_0098808Molecular functionmRNA cap binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEIF3D
Protein nameEukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)
Eukaryotic translation initiation factor 3 subunit D
Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta)
SynonymsEIF3S7
DescriptionFUNCTION: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs . .; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 . .

FUNCTION: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. .

AccessionsA0A0D9SGB5
ENST00000402116.2
ENST00000455547.5
ENST00000216190.13 [O15371-1]
ENST00000458572.1
B0QYA5
B4E1K8
B0QYA4
ENST00000405442.5 [O15371-1]
B0QYA6
ENST00000478547.1
ENST00000457241.5
B0QYA8
O15371