NLGN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	16 studies	66% ± 22%	Explore
oligodendrocyte precursor cell	15 studies	90% ± 18%	Explore
astrocyte	14 studies	45% ± 21%	Explore
glutamatergic neuron	13 studies	80% ± 21%	Explore
GABAergic neuron	11 studies	74% ± 25%	Explore
endothelial cell	10 studies	40% ± 22%	Explore
microglial cell	9 studies	44% ± 21%	Explore
adipocyte	9 studies	26% ± 8%	Explore
neuron	6 studies	51% ± 17%	Explore
interneuron	6 studies	70% ± 24%	Explore
cardiac muscle cell	6 studies	58% ± 21%	Explore
fibroblast	5 studies	28% ± 10%	Explore
pericyte	5 studies	30% ± 9%	Explore
smooth muscle cell	5 studies	29% ± 6%	Explore
granule cell	4 studies	82% ± 17%	Explore
mesothelial cell	4 studies	42% ± 20%	Explore
Mueller cell	4 studies	89% ± 9%	Explore
retinal rod cell	4 studies	74% ± 10%	Explore
type II pneumocyte	4 studies	21% ± 4%	Explore
macrophage	3 studies	35% ± 6%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	91% ± 5%	Explore
GABAergic interneuron	3 studies	87% ± 4%	Explore
epithelial cell	3 studies	42% ± 16%	Explore
glial cell	3 studies	40% ± 10%	Explore
progenitor cell	3 studies	64% ± 25%	Explore
GABAergic amacrine cell	3 studies	55% ± 15%	Explore
amacrine cell	3 studies	61% ± 8%	Explore
glycinergic amacrine cell	3 studies	55% ± 7%	Explore
retinal cone cell	3 studies	42% ± 20%	Explore
retinal ganglion cell	3 studies	52% ± 13%	Explore
rod bipolar cell	3 studies	69% ± 35%	Explore
ependymal cell	3 studies	53% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	65% ± 21%	Explore
eye	5 studies	57% ± 18%	Explore
heart	4 studies	35% ± 8%	Explore
adipose	3 studies	41% ± 23%	Explore
kidney	3 studies	28% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	887.76	2639 / 2642	100%	20.32	702 / 705
kidney	80%	201.70	71 / 89	84%	9.75	753 / 901
skin	41%	103.23	740 / 1809	73%	8.17	346 / 472
prostate	92%	227.80	226 / 245	12%	0.60	60 / 502
bladder	100%	535.95	21 / 21	4%	0.15	20 / 504
uterus	96%	264.62	163 / 170	7%	0.35	33 / 459
blood vessel	99%	622.99	1319 / 1335	0%	0	0 / 0
adipose	96%	268.71	1156 / 1204	0%	0	0 / 0
breast	92%	191.86	421 / 459	4%	0.19	45 / 1118
esophagus	77%	298.94	1116 / 1445	5%	0.38	10 / 183
intestine	75%	325.26	721 / 966	2%	0.07	11 / 527
ovary	67%	160.65	120 / 180	9%	0.38	40 / 430
adrenal gland	12%	19.71	31 / 258	46%	2.57	106 / 230
heart	58%	149.62	497 / 861	0%	0	0 / 0
stomach	55%	153.64	196 / 359	2%	0.08	6 / 286
thymus	44%	62.28	290 / 653	2%	0.07	14 / 605
lung	24%	34.12	138 / 578	8%	0.41	93 / 1155
eye	0%	0	0 / 0	13%	0.53	10 / 80
pancreas	3%	4.04	11 / 328	4%	0.21	8 / 178
lymph node	0%	0	0 / 0	7%	0.33	2 / 29
muscle	5%	7.31	43 / 803	0%	0	0 / 0
liver	0%	0	0 / 226	4%	0.23	17 / 406
tonsil	0%	0	0 / 0	2%	0.11	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0045664	Biological process	regulation of neuron differentiation
GO_0097119	Biological process	postsynaptic density protein 95 clustering
GO_1900244	Biological process	positive regulation of synaptic vesicle endocytosis
GO_0097104	Biological process	postsynaptic membrane assembly
GO_0016080	Biological process	synaptic vesicle targeting
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_2000302	Biological process	positive regulation of synaptic vesicle exocytosis
GO_0045184	Biological process	establishment of protein localization
GO_0031175	Biological process	neuron projection development
GO_0097113	Biological process	AMPA glutamate receptor clustering
GO_0048488	Biological process	synaptic vesicle endocytosis
GO_0097120	Biological process	receptor localization to synapse
GO_2000310	Biological process	regulation of NMDA receptor activity
GO_1900029	Biological process	positive regulation of ruffle assembly
GO_0061002	Biological process	negative regulation of dendritic spine morphogenesis
GO_1900075	Biological process	positive regulation of neuromuscular synaptic transmission
GO_1902533	Biological process	positive regulation of intracellular signal transduction
GO_1904861	Biological process	excitatory synapse assembly
GO_0006605	Biological process	protein targeting
GO_0097114	Biological process	NMDA glutamate receptor clustering
GO_2000463	Biological process	positive regulation of excitatory postsynaptic potential
GO_0071277	Biological process	cellular response to calcium ion
GO_0048812	Biological process	neuron projection morphogenesis
GO_0051491	Biological process	positive regulation of filopodium assembly
GO_0097115	Biological process	neurexin clustering involved in presynaptic membrane assembly
GO_0007268	Biological process	chemical synaptic transmission
GO_0140058	Biological process	neuron projection arborization
GO_0060999	Biological process	positive regulation of dendritic spine development
GO_2000311	Biological process	regulation of AMPA receptor activity
GO_0016339	Biological process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0099054	Biological process	presynapse assembly
GO_0023041	Biological process	neuronal signal transduction
GO_0097091	Biological process	synaptic vesicle clustering
GO_0010841	Biological process	positive regulation of circadian sleep/wake cycle, wakefulness
GO_0072553	Biological process	terminal button organization
GO_0051968	Biological process	positive regulation of synaptic transmission, glutamatergic
GO_0007416	Biological process	synapse assembly
GO_0035418	Biological process	protein localization to synapse
GO_0032230	Biological process	positive regulation of synaptic transmission, GABAergic
GO_0051965	Biological process	positive regulation of synapse assembly
GO_0007158	Biological process	neuron cell-cell adhesion
GO_0048789	Biological process	cytoskeletal matrix organization at active zone
GO_0007157	Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0048511	Biological process	rhythmic process
GO_0097105	Biological process	presynaptic membrane assembly
GO_0007399	Biological process	nervous system development
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0098635	Cellular component	protein complex involved in cell-cell adhesion
GO_0098985	Cellular component	asymmetric, glutamatergic, excitatory synapse
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0043197	Cellular component	dendritic spine
GO_0016020	Cellular component	membrane
GO_0032433	Cellular component	filopodium tip
GO_0098794	Cellular component	postsynapse
GO_0005794	Cellular component	Golgi apparatus
GO_0030425	Cellular component	dendrite
GO_0098982	Cellular component	GABA-ergic synapse
GO_0009986	Cellular component	cell surface
GO_0045202	Cellular component	synapse
GO_0014069	Cellular component	postsynaptic density
GO_0099634	Cellular component	postsynaptic specialization membrane
GO_0045211	Cellular component	postsynaptic membrane
GO_0043083	Cellular component	synaptic cleft
GO_0060076	Cellular component	excitatory synapse
GO_0038023	Molecular function	signaling receptor activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0042802	Molecular function	identical protein binding
GO_0042043	Molecular function	neurexin family protein binding
GO_0030165	Molecular function	PDZ domain binding
GO_0097110	Molecular function	scaffold protein binding
GO_0050839	Molecular function	cell adhesion molecule binding

IV. Literature review

[source]

Gene name	NLGN1
Protein name	Neuroligin-1 Neuroligin 1
Synonyms	KIAA1070
Description	FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development. .
Accessions	A0A8Q3SHM6 ENST00000415045.2 ENST00000423427.1 C9JWG7 ENST00000361589.8 [Q8N2Q7-2] ENST00000695368.1 A0A1D5RMP7 ENST00000413821.1 ENST00000415045.2 [Q8N2Q7-3] Q8N2Q7 C9J4D3 ENST00000457714.5 [Q8N2Q7-2]

NLGN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review