DACT1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DACT1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DACT1 at tissue level.

III. Associated gene sets

GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_1900107Biological processregulation of nodal signaling pathway
GO_0032092Biological processpositive regulation of protein binding
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0048619Biological processembryonic hindgut morphogenesis
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0046329Biological processnegative regulation of JNK cascade
GO_2000095Biological processregulation of Wnt signaling pathway, planar cell polarity pathway
GO_1904864Biological processnegative regulation of beta-catenin-TCF complex assembly
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0016055Biological processWnt signaling pathway
GO_0032091Biological processnegative regulation of protein binding
GO_0021915Biological processneural tube development
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0031647Biological processregulation of protein stability
GO_0005654Cellular componentnucleoplasm
GO_0030877Cellular componentbeta-catenin destruction complex
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0070097Molecular functiondelta-catenin binding
GO_0005080Molecular functionprotein kinase C binding
GO_0008013Molecular functionbeta-catenin binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0051018Molecular functionprotein kinase A binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameDACT1
Protein nameDapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein)
Dishevelled binding antagonist of beta catenin 1 (cDNA FLJ51077, highly similar to Dapper homolog 1) (cDNA, FLJ79063, highly similar to Dapper homolog 1) (cDNA, FLJ79136, highly similar to Dapper homolog 1)
Dishevelled binding antagonist of beta catenin 1
SynonymsDPR1
HNG3
DescriptionFUNCTION: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. .

AccessionsENST00000707126.1 [Q9NYF0-2]
Q9NYF0
ENST00000541264.2
B7Z673
C9JGV7
ENST00000556859.5
ENST00000395153.8 [Q9NYF0-2]
ENST00000335867.4 [Q9NYF0-1]
ENST00000421793.5