GO_0090263 | OmnibusX

positive regulation of canonical Wnt signaling pathway

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	EGF-EGFR	EGF_HUMAN - EGFR_HUMAN	Ligand-Receptor	Signaling by Epidermal growth factor
2	FGF10-FGFR2	FGF10_HUMAN - FGFR2_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
3	FGF2-FGFR2	FGF2_HUMAN - FGFR2_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
4	RSPO1-LGR4	RSPO1_HUMAN - LGR4_HUMAN	Ligand-Receptor	Signaling by R-spondin
5	RSPO1-LGR5	RSPO1_HUMAN - LGR5_HUMAN	Ligand-Receptor	Signaling by R-spondin
6	RSPO1-LGR6	RSPO1_HUMAN - LGR6_HUMAN	Ligand-Receptor	Signaling by R-spondin
7	RSPO2-LGR4	RSPO2_HUMAN - LGR4_HUMAN	Ligand-Receptor	Signaling by R-spondin
8	RSPO2-LGR5	RSPO2_HUMAN - LGR5_HUMAN	Ligand-Receptor	Signaling by R-spondin
9	RSPO2-LGR6	RSPO2_HUMAN - LGR6_HUMAN	Ligand-Receptor	Signaling by R-spondin
10	RSPO3-LGR4	RSPO3_HUMAN - LGR4_HUMAN	Ligand-Receptor	Signaling by R-spondin
11	RSPO3-LGR5	RSPO3_HUMAN - LGR5_HUMAN	Ligand-Receptor	Signaling by R-spondin
12	RSPO3-LGR6	RSPO3_HUMAN - LGR6_HUMAN	Ligand-Receptor	Signaling by R-spondin
13	WNT3A-FZD9+LRP5	WNT3A_HUMAN -	Ligand-Receptor	Signaling by WNT
14	WNT3A-FZD9+LRP6	WNT3A_HUMAN -	Ligand-Receptor	Signaling by WNT
15	WNT3A-SFRP1	WNT3A_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
16	WNT3A-SFRP2	WNT3A_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
17	WNT3A-SFRP4	WNT3A_HUMAN - SFRP4_HUMAN	Ligand-Ligand	Signaling by WNT inhibition

II. Literature review

Name	positive regulation of canonical Wnt signaling pathway
ID	GO_0090263
collection_id	Biological process
Alternative ID	GO:0035413
Exact synonym	positive regulation of Wnt receptor signaling pathway through beta-catenin, positive regulation of canonical Wnt receptor signaling pathway, positive regulation of canonical Wnt receptor signalling pathway, positive regulation of canonical Wnt-activated signaling pathway
Description	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
External URL
Genes	SFRP4 TTC21B GPC5 DACT1 SFRP1 URS0000134ADC_9606 DAAM2 CCAR2 CTDNEP1 WNK2 ATP6AP2 KANK1 JUP RPS12 LGR4 BMAL1 SOX4 FGF9 TNKS PIN1 SFRP2 SEMA5A URS0000239117_9606 FGF2 YAP1 GPRC5B CAPRIN2 CSNK1D SPIN4 TRPM4 AMER1 WNK1 LGR5 DKK2 USP8 SMURF2 SRC SCEL URS0000528CBC_9606 RUVBL1 TBL1X TGFB1 EGFR CSNK1G3 GSKIP ILK FZD9 NLE1 CDH3 GPC3 GID8 ZEB2 RSPO3 PPM1A JRK PPM1N EGF FAM53B URS00001E2DBC_9606 CSNK1E NRARP TBL1XR1 XIAP RNF220 FRAT1 URS000019B0F7_9606 TMEM9 BAMBI SULF2 USP34 UBR5 PTK7 LGR6 VPS35 NFKB1 LRRK2 DLX5 ADNP URS000024463E_9606 TMEM198 WNT10B WNT3A SMAD3 DDX3X PRDM15 BIRC8 VCP LRRK1 DAPK3 CSNK1G1 TNKS2 PPM1B PLEKHA4 RSPO1 ASPM LYPD6 CSNK1G2 FGF10 ZBED3 HHEX URS000075A607_9606 UBE2B URS0000527F89_9606 RBPJ COL1A1 USP47 FGFR2 RSPO2 ADGRA2 EDA RNF146 RECK WLS