GID8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD16-negative, CD56-bright natural killer cell, human	9 studies	20% ± 4%	Explore
natural killer cell	9 studies	21% ± 4%	Explore
B cell	8 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	20% ± 4%	Explore
epithelial cell	7 studies	36% ± 16%	Explore
ciliated cell	7 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	6 studies	21% ± 5%	Explore
classical monocyte	6 studies	25% ± 9%	Explore
endothelial cell	6 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	5 studies	22% ± 5%	Explore
basal cell	5 studies	35% ± 11%	Explore
regulatory T cell	5 studies	19% ± 4%	Explore
abnormal cell	5 studies	20% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	19% ± 4%	Explore
precursor B cell	4 studies	22% ± 2%	Explore
T follicular helper cell	4 studies	17% ± 2%	Explore
naive B cell	4 studies	20% ± 5%	Explore
T cell	4 studies	18% ± 4%	Explore
gamma-delta T cell	4 studies	25% ± 14%	Explore
squamous epithelial cell	3 studies	39% ± 22%	Explore
conventional dendritic cell	3 studies	36% ± 12%	Explore
non-classical monocyte	3 studies	37% ± 10%	Explore
fibroblast	3 studies	22% ± 5%	Explore
exhausted T cell	3 studies	17% ± 2%	Explore
glutamatergic neuron	3 studies	30% ± 12%	Explore
transit amplifying cell	3 studies	22% ± 5%	Explore
goblet cell	3 studies	22% ± 6%	Explore
neuron	3 studies	17% ± 3%	Explore
plasmacytoid dendritic cell	3 studies	23% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	21% ± 7%	Explore
mucosal invariant T cell	3 studies	16% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	21% ± 6%	Explore
lung	6 studies	22% ± 6%	Explore
brain	3 studies	24% ± 10%	Explore
intestine	3 studies	19% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4727.26	1445 / 1445	100%	67.26	183 / 183
lung	100%	2876.97	578 / 578	100%	73.80	1155 / 1155
ovary	100%	4788.42	180 / 180	100%	69.85	430 / 430
prostate	100%	3759.60	245 / 245	100%	72.14	502 / 502
uterus	100%	3823.12	170 / 170	100%	84.44	459 / 459
brain	100%	2882.51	2640 / 2642	100%	72.66	705 / 705
breast	100%	3380.46	459 / 459	100%	95.10	1117 / 1118
intestine	100%	3602.05	966 / 966	100%	80.15	526 / 527
bladder	100%	3459.86	21 / 21	100%	83.52	503 / 504
pancreas	100%	2476.08	327 / 328	100%	61.10	178 / 178
thymus	100%	3678.08	653 / 653	100%	67.32	603 / 605
stomach	100%	3082.95	359 / 359	100%	76.31	285 / 286
liver	100%	2775.32	226 / 226	100%	44.29	404 / 406
skin	100%	5405.04	1809 / 1809	99%	62.69	468 / 472
kidney	100%	2894.89	89 / 89	99%	44.98	893 / 901
adrenal gland	100%	2778.31	258 / 258	98%	44.91	225 / 230
adipose	100%	2795.98	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	48.28	80 / 80
lymph node	0%	0	0 / 0	100%	65.18	29 / 29
spleen	100%	3688.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	80.47	45 / 45
ureter	0%	0	0 / 0	100%	56.27	1 / 1
blood vessel	100%	3142.46	1334 / 1335	0%	0	0 / 0
muscle	100%	1853.42	799 / 803	0%	0	0 / 0
peripheral blood	99%	2802.20	922 / 929	0%	0	0 / 0
heart	99%	1896.44	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0016055	Biological process	Wnt signaling pathway
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0030054	Cellular component	cell junction
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GID8
Protein name	Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)
Synonyms	C20orf11 TWA1
Description	FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 . Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation . .
Accessions	ENST00000266069.5 Q9NWU2

GID8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review