Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 18 studies | 29% ± 14% | |
| oligodendrocyte | 17 studies | 56% ± 19% | |
| astrocyte | 14 studies | 49% ± 19% | |
| smooth muscle cell | 11 studies | 28% ± 10% | |
| endothelial cell | 7 studies | 35% ± 15% | |
| adipocyte | 5 studies | 26% ± 6% | |
| macrophage | 5 studies | 23% ± 4% | |
| fibroblast | 4 studies | 28% ± 11% | |
| muscle cell | 4 studies | 26% ± 12% | |
| myofibroblast cell | 3 studies | 27% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 7 studies | 37% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 96% | 12087.05 | 2534 / 2642 | 98% | 78.03 | 691 / 705 |
| skin | 59% | 1778.11 | 1074 / 1809 | 97% | 38.66 | 456 / 472 |
| breast | 100% | 6377.96 | 457 / 459 | 53% | 3.36 | 591 / 1118 |
| thymus | 97% | 3822.80 | 634 / 653 | 50% | 3.49 | 302 / 605 |
| lung | 94% | 3432.87 | 543 / 578 | 43% | 3.71 | 498 / 1155 |
| ovary | 80% | 2219.71 | 144 / 180 | 57% | 4.73 | 244 / 430 |
| adrenal gland | 94% | 4427.17 | 243 / 258 | 39% | 2.93 | 90 / 230 |
| prostate | 80% | 2563.42 | 195 / 245 | 52% | 3.19 | 260 / 502 |
| esophagus | 84% | 14563.03 | 1215 / 1445 | 39% | 3.66 | 71 / 183 |
| uterus | 96% | 3698.55 | 163 / 170 | 23% | 1.91 | 106 / 459 |
| intestine | 97% | 4280.01 | 933 / 966 | 19% | 1.17 | 102 / 527 |
| kidney | 60% | 1670.57 | 53 / 89 | 53% | 5.98 | 479 / 901 |
| stomach | 77% | 3670.58 | 275 / 359 | 33% | 2.69 | 95 / 286 |
| bladder | 86% | 2363.52 | 18 / 21 | 17% | 1.02 | 86 / 504 |
| adipose | 100% | 7939.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.24 | 1 / 1 |
| blood vessel | 100% | 8763.61 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 28.98 | 79 / 80 |
| spleen | 98% | 8921.99 | 235 / 241 | 0% | 0 | 0 / 0 |
| muscle | 87% | 5443.51 | 695 / 803 | 0% | 0 | 0 / 0 |
| pancreas | 18% | 355.23 | 58 / 328 | 48% | 3.32 | 85 / 178 |
| heart | 56% | 1320.79 | 482 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 37% | 2927.42 | 343 / 929 | 0% | 0 | 0 / 0 |
| liver | 4% | 78.94 | 9 / 226 | 13% | 0.72 | 52 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.54 | 6 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.14 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0021516 | Biological process | dorsal spinal cord development |
| GO_0051489 | Biological process | regulation of filopodium assembly |
| GO_2000050 | Biological process | regulation of non-canonical Wnt signaling pathway |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0048715 | Biological process | negative regulation of oligodendrocyte differentiation |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0030833 | Biological process | regulation of actin filament polymerization |
| GO_0060828 | Biological process | regulation of canonical Wnt signaling pathway |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0007368 | Biological process | determination of left/right symmetry |
| GO_0090521 | Biological process | podocyte cell migration |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| GO_0031267 | Molecular function | small GTPase binding |
| Gene name | DAAM2 |
| Protein name | DAAM2 protein Disheveled-associated activator of morphogenesis 2 Dishevelled associated activator of morphogenesis 2 |
| Synonyms | KIAA0381 hCG_33196 |
| Description | FUNCTION: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration . . |
| Accessions | ENST00000398904.6 [Q86T65-3] A0A0J9YX09 ENST00000633794.1 ENST00000538976.5 [Q86T65-4] ENST00000274867.9 [Q86T65-3] ENST00000405961.3 Q6DCB0 F2Z2Q2 ENST00000494405.2 A0A0J9YYF7 Q86T65 |
