Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 26 studies | 35% ± 13% | |
astrocyte | 12 studies | 39% ± 16% | |
fibroblast | 11 studies | 27% ± 9% | |
macrophage | 10 studies | 31% ± 13% | |
microglial cell | 10 studies | 39% ± 12% | |
oligodendrocyte precursor cell | 9 studies | 28% ± 13% | |
endothelial cell of artery | 8 studies | 26% ± 14% | |
type I pneumocyte | 7 studies | 31% ± 13% | |
interneuron | 6 studies | 33% ± 16% | |
epithelial cell | 6 studies | 33% ± 12% | |
myeloid cell | 6 studies | 23% ± 3% | |
T cell | 6 studies | 26% ± 4% | |
endothelial cell of lymphatic vessel | 6 studies | 27% ± 9% | |
oligodendrocyte | 6 studies | 25% ± 8% | |
dendritic cell | 5 studies | 23% ± 3% | |
ciliated cell | 5 studies | 27% ± 9% | |
basal cell | 5 studies | 27% ± 18% | |
GABAergic neuron | 5 studies | 36% ± 12% | |
capillary endothelial cell | 5 studies | 30% ± 14% | |
club cell | 5 studies | 29% ± 12% | |
pericyte | 5 studies | 25% ± 5% | |
smooth muscle cell | 5 studies | 23% ± 6% | |
type II pneumocyte | 5 studies | 35% ± 8% | |
adipocyte | 4 studies | 22% ± 6% | |
vein endothelial cell | 4 studies | 29% ± 12% | |
lymphocyte | 4 studies | 31% ± 14% | |
retinal rod cell | 4 studies | 29% ± 4% | |
monocyte | 4 studies | 26% ± 6% | |
natural killer cell | 4 studies | 22% ± 7% | |
gamma-delta T cell | 3 studies | 21% ± 1% | |
granule cell | 3 studies | 22% ± 2% | |
neuron | 3 studies | 29% ± 12% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 4% | |
mesothelial cell | 3 studies | 29% ± 10% | |
Mueller cell | 3 studies | 23% ± 5% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 19% ± 0% | |
endothelial cell of vascular tree | 3 studies | 35% ± 13% | |
glutamatergic neuron | 3 studies | 54% ± 12% | |
alveolar macrophage | 3 studies | 31% ± 7% | |
respiratory goblet cell | 3 studies | 29% ± 15% | |
leukocyte | 3 studies | 51% ± 6% | |
mast cell | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1992.56 | 1445 / 1445 | 100% | 18.93 | 183 / 183 |
lung | 100% | 3743.44 | 578 / 578 | 100% | 24.74 | 1155 / 1155 |
ovary | 100% | 2236.81 | 180 / 180 | 100% | 13.93 | 430 / 430 |
prostate | 100% | 2382.26 | 245 / 245 | 100% | 21.08 | 502 / 502 |
brain | 100% | 1657.91 | 2640 / 2642 | 100% | 20.50 | 705 / 705 |
breast | 100% | 2192.97 | 459 / 459 | 100% | 21.18 | 1115 / 1118 |
bladder | 100% | 2053.05 | 21 / 21 | 99% | 17.29 | 501 / 504 |
intestine | 100% | 2057.44 | 966 / 966 | 99% | 14.29 | 523 / 527 |
thymus | 100% | 2347.33 | 653 / 653 | 99% | 22.84 | 600 / 605 |
stomach | 100% | 1598.08 | 359 / 359 | 99% | 14.18 | 282 / 286 |
pancreas | 100% | 937.54 | 327 / 328 | 99% | 17.39 | 176 / 178 |
uterus | 100% | 2291.39 | 170 / 170 | 98% | 15.66 | 450 / 459 |
kidney | 100% | 1495.98 | 89 / 89 | 97% | 15.28 | 870 / 901 |
skin | 100% | 3076.52 | 1809 / 1809 | 95% | 15.88 | 447 / 472 |
adrenal gland | 100% | 1651.60 | 258 / 258 | 93% | 7.76 | 215 / 230 |
liver | 74% | 389.17 | 167 / 226 | 62% | 4.95 | 253 / 406 |
adipose | 100% | 2425.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2200.45 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1952.55 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.43 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.47 | 1 / 1 |
muscle | 99% | 896.09 | 797 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 1105.93 | 850 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 7.56 | 25 / 29 |
peripheral blood | 79% | 676.07 | 735 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 71% | 4.80 | 57 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0017015 | Biological process | regulation of transforming growth factor beta receptor signaling pathway |
GO_0016567 | Biological process | protein ubiquitination |
GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
GO_1901165 | Biological process | positive regulation of trophoblast cell migration |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0060071 | Biological process | Wnt signaling pathway, planar cell polarity pathway |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0005886 | Cellular component | plasma membrane |
GO_0045121 | Cellular component | membrane raft |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0046332 | Molecular function | SMAD binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SMURF2 |
Protein name | SMAD specific E3 ubiquitin protein ligase 2 Alternative protein SMURF2 E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) HECT-type E3 ubiquitin transferase (EC 2.3.2.26) |
Synonyms | |
Description | FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling . In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 . Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation . SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation . Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation . .; FUNCTION: (Microbial infection) In case of filoviruses Ebola/EBOV and Marburg/MARV infection, the complex formed by viral matrix protein VP40 and SMURF2 facilitates virus budding. . |
Accessions | ENST00000585301.1 L8EAC0 ENST00000582081.5 J3QQM4 J3QRY2 ENST00000578386.5 J3QLG1 Q96DE7 ENST00000262435.14 Q9HAU4 |