SMURF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0017015Biological processregulation of transforming growth factor beta receptor signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_1901165Biological processpositive regulation of trophoblast cell migration
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046332Molecular functionSMAD binding
GO_0042802Molecular functionidentical protein binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMURF2
Protein nameSMAD specific E3 ubiquitin protein ligase 2
Alternative protein SMURF2
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling . In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 . Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation . SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation . Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation . .; FUNCTION: (Microbial infection) In case of filoviruses Ebola/EBOV and Marburg/MARV infection, the complex formed by viral matrix protein VP40 and SMURF2 facilitates virus budding. .

AccessionsENST00000585301.1
L8EAC0
ENST00000582081.5
J3QQM4
J3QRY2
ENST00000578386.5
J3QLG1
Q96DE7
ENST00000262435.14
Q9HAU4