CSNK1G2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0030148Biological processsphingolipid biosynthetic process
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0016055Biological processWnt signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0006897Biological processendocytosis
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCSNK1G2
Protein nameCasein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Casein kinase 1 gamma 2
SynonymsCK1G2
DescriptionFUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation . Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels . .

AccessionsP78368
K7EP38
ENST00000255641.13
ENST00000585959.2
K7ESB6
ENST00000591002.5
ENST00000589350.2
A0A087WXD7
A0A087WW97
K7EJC0
ENST00000591752.5
ENST00000589385.5
A0A087WZK4
A0A087WWF5
ENST00000615564.1
ENST00000585957.2