LGR4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036335Biological processintestinal stem cell homeostasis
GO_0007283Biological processspermatogenesis
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0045087Biological processinnate immune response
GO_0001649Biological processosteoblast differentiation
GO_0032922Biological processcircadian regulation of gene expression
GO_0007190Biological processactivation of adenylate cyclase activity
GO_0046849Biological processbone remodeling
GO_0030539Biological processmale genitalia development
GO_0072224Biological processmetanephric glomerulus development
GO_0030282Biological processbone mineralization
GO_0001942Biological processhair follicle development
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0090190Biological processpositive regulation of branching involved in ureteric bud morphogenesis
GO_0001818Biological processnegative regulation of cytokine production
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0048565Biological processdigestive tract development
GO_0072282Biological processmetanephric nephron tubule morphogenesis
GO_2001013Biological processepithelial cell proliferation involved in renal tubule morphogenesis
GO_0016055Biological processWnt signaling pathway
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0008528Molecular functionG protein-coupled peptide receptor activity
GO_0016500Molecular functionprotein-hormone receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLGR4
Protein nameLeucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48)
Leucine rich repeat containing G protein-coupled receptor 4
SynonymsGPR48
DescriptionFUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity). Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity). .

AccessionsENST00000379214.9 [Q9BXB1-1]
Q9BXB1
ENST00000480977.2
ENST00000389858.4 [Q9BXB1-2]
E9PK51