Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 19 studies | 42% ± 18% | |
adipocyte | 9 studies | 43% ± 15% | |
epithelial cell | 7 studies | 40% ± 19% | |
endothelial cell | 6 studies | 26% ± 13% | |
fibroblast | 6 studies | 32% ± 11% | |
Mueller cell | 6 studies | 68% ± 25% | |
oligodendrocyte | 6 studies | 26% ± 9% | |
interneuron | 5 studies | 30% ± 15% | |
kidney loop of Henle epithelial cell | 5 studies | 35% ± 15% | |
basal cell | 5 studies | 36% ± 22% | |
retina horizontal cell | 5 studies | 31% ± 18% | |
ciliated cell | 5 studies | 27% ± 13% | |
GABAergic neuron | 5 studies | 36% ± 15% | |
oligodendrocyte precursor cell | 4 studies | 24% ± 4% | |
amacrine cell | 4 studies | 42% ± 15% | |
retinal cone cell | 4 studies | 25% ± 4% | |
hepatocyte | 4 studies | 56% ± 16% | |
glutamatergic neuron | 4 studies | 46% ± 12% | |
granule cell | 3 studies | 24% ± 5% | |
neuron | 3 studies | 27% ± 11% | |
cardiac muscle cell | 3 studies | 19% ± 3% | |
GABAergic amacrine cell | 3 studies | 58% ± 10% | |
glycinergic amacrine cell | 3 studies | 43% ± 12% | |
acinar cell | 3 studies | 45% ± 15% | |
abnormal cell | 3 studies | 32% ± 16% | |
ependymal cell | 3 studies | 40% ± 21% | |
goblet cell | 3 studies | 17% ± 1% | |
intestinal crypt stem cell | 3 studies | 18% ± 1% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 55% ± 10% | |
renal alpha-intercalated cell | 3 studies | 49% ± 20% | |
mucus secreting cell | 3 studies | 28% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 4407.49 | 89 / 89 | 98% | 47.79 | 880 / 901 |
stomach | 100% | 2865.13 | 359 / 359 | 98% | 47.31 | 279 / 286 |
intestine | 100% | 3841.18 | 965 / 966 | 97% | 40.31 | 510 / 527 |
esophagus | 100% | 2313.87 | 1442 / 1445 | 97% | 50.93 | 177 / 183 |
prostate | 100% | 2073.56 | 245 / 245 | 96% | 31.64 | 480 / 502 |
ovary | 100% | 3749.81 | 180 / 180 | 96% | 39.00 | 411 / 430 |
liver | 100% | 3574.15 | 226 / 226 | 95% | 37.87 | 387 / 406 |
pancreas | 100% | 7070.76 | 328 / 328 | 93% | 31.57 | 165 / 178 |
brain | 96% | 1585.04 | 2538 / 2642 | 94% | 17.96 | 666 / 705 |
thymus | 100% | 1889.89 | 651 / 653 | 90% | 23.16 | 546 / 605 |
uterus | 100% | 1949.81 | 170 / 170 | 82% | 22.64 | 376 / 459 |
bladder | 100% | 1824.76 | 21 / 21 | 78% | 20.38 | 395 / 504 |
breast | 99% | 2054.71 | 454 / 459 | 76% | 19.00 | 847 / 1118 |
lung | 79% | 690.63 | 457 / 578 | 95% | 37.30 | 1103 / 1155 |
skin | 98% | 2988.17 | 1779 / 1809 | 60% | 11.48 | 283 / 472 |
adrenal gland | 100% | 3288.33 | 258 / 258 | 45% | 8.96 | 104 / 230 |
blood vessel | 100% | 2407.90 | 1331 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 1969.35 | 1186 / 1204 | 0% | 0 | 0 / 0 |
muscle | 97% | 1289.58 | 777 / 803 | 0% | 0 | 0 / 0 |
spleen | 96% | 1467.67 | 232 / 241 | 0% | 0 | 0 / 0 |
heart | 95% | 2630.06 | 820 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 80% | 20.03 | 36 / 45 |
eye | 0% | 0 | 0 / 0 | 26% | 3.29 | 21 / 80 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.77 | 1 / 29 |
peripheral blood | 2% | 18.32 | 22 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0036335 | Biological process | intestinal stem cell homeostasis |
GO_0007283 | Biological process | spermatogenesis |
GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
GO_0045087 | Biological process | innate immune response |
GO_0001649 | Biological process | osteoblast differentiation |
GO_0032922 | Biological process | circadian regulation of gene expression |
GO_0007190 | Biological process | activation of adenylate cyclase activity |
GO_0046849 | Biological process | bone remodeling |
GO_0030539 | Biological process | male genitalia development |
GO_0072224 | Biological process | metanephric glomerulus development |
GO_0030282 | Biological process | bone mineralization |
GO_0001942 | Biological process | hair follicle development |
GO_0034122 | Biological process | negative regulation of toll-like receptor signaling pathway |
GO_0090190 | Biological process | positive regulation of branching involved in ureteric bud morphogenesis |
GO_0001818 | Biological process | negative regulation of cytokine production |
GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
GO_0048565 | Biological process | digestive tract development |
GO_0072282 | Biological process | metanephric nephron tubule morphogenesis |
GO_2001013 | Biological process | epithelial cell proliferation involved in renal tubule morphogenesis |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0120163 | Biological process | negative regulation of cold-induced thermogenesis |
GO_0005886 | Cellular component | plasma membrane |
GO_0004930 | Molecular function | G protein-coupled receptor activity |
GO_0004888 | Molecular function | transmembrane signaling receptor activity |
GO_0008528 | Molecular function | G protein-coupled peptide receptor activity |
GO_0016500 | Molecular function | protein-hormone receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | LGR4 |
Protein name | Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) Leucine rich repeat containing G protein-coupled receptor 4 |
Synonyms | GPR48 |
Description | FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity). Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity). . |
Accessions | ENST00000379214.9 [Q9BXB1-1] Q9BXB1 ENST00000480977.2 ENST00000389858.4 [Q9BXB1-2] E9PK51 |