ILK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	31 studies	29% ± 12%	Explore
smooth muscle cell	27 studies	43% ± 17%	Explore
pericyte	27 studies	36% ± 13%	Explore
endothelial cell	24 studies	25% ± 11%	Explore
natural killer cell	20 studies	23% ± 7%	Explore
macrophage	17 studies	23% ± 7%	Explore
myofibroblast cell	15 studies	41% ± 14%	Explore
endothelial cell of lymphatic vessel	12 studies	23% ± 7%	Explore
capillary endothelial cell	12 studies	23% ± 6%	Explore
connective tissue cell	12 studies	36% ± 14%	Explore
conventional dendritic cell	11 studies	27% ± 12%	Explore
non-classical monocyte	11 studies	28% ± 10%	Explore
classical monocyte	11 studies	25% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	23% ± 6%	Explore
type I pneumocyte	9 studies	21% ± 4%	Explore
platelet	9 studies	47% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	23% ± 8%	Explore
endothelial cell of artery	9 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	8 studies	22% ± 4%	Explore
regulatory T cell	7 studies	19% ± 2%	Explore
gamma-delta T cell	7 studies	21% ± 6%	Explore
T cell	6 studies	20% ± 3%	Explore
monocyte	6 studies	21% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	17% ± 1%	Explore
megakaryocyte	6 studies	67% ± 27%	Explore
dendritic cell	6 studies	32% ± 18%	Explore
epithelial cell	6 studies	35% ± 18%	Explore
plasmacytoid dendritic cell	6 studies	21% ± 5%	Explore
mature NK T cell	5 studies	21% ± 4%	Explore
basal cell	5 studies	29% ± 10%	Explore
neuron	5 studies	33% ± 14%	Explore
astrocyte	5 studies	27% ± 7%	Explore
cardiac muscle cell	5 studies	19% ± 2%	Explore
endothelial cell of vascular tree	5 studies	26% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	21% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	25% ± 10%	Explore
vein endothelial cell	4 studies	21% ± 2%	Explore
B cell	4 studies	21% ± 6%	Explore
myeloid cell	4 studies	23% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	21% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	26% ± 2%	Explore
innate lymphoid cell	4 studies	19% ± 4%	Explore
microglial cell	4 studies	18% ± 3%	Explore
oligodendrocyte precursor cell	4 studies	19% ± 3%	Explore
goblet cell	4 studies	22% ± 8%	Explore
pancreatic A cell	3 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
leukocyte	3 studies	21% ± 6%	Explore
lymphocyte	3 studies	26% ± 8%	Explore
Schwann cell	3 studies	33% ± 19%	Explore
mesothelial cell	3 studies	34% ± 16%	Explore
ciliated cell	3 studies	33% ± 3%	Explore
abnormal cell	3 studies	37% ± 16%	Explore
exhausted T cell	3 studies	21% ± 5%	Explore
intermediate monocyte	3 studies	29% ± 13%	Explore
muscle cell	3 studies	45% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
glial cell	3 studies	32% ± 18%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 12%	Explore
mucosal invariant T cell	3 studies	16% ± 0%	Explore
mast cell	3 studies	23% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	20% ± 4%	Explore
lung	6 studies	31% ± 10%	Explore
intestine	5 studies	28% ± 13%	Explore
brain	5 studies	25% ± 9%	Explore
heart	4 studies	17% ± 2%	Explore
uterus	4 studies	27% ± 8%	Explore
pancreas	3 studies	22% ± 5%	Explore
kidney	3 studies	21% ± 2%	Explore
liver	3 studies	27% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	6567.07	89 / 89	20%	0.33	184 / 901
stomach	98%	10116.47	353 / 359	19%	0.31	55 / 286
intestine	100%	20615.31	966 / 966	13%	0.21	67 / 527
prostate	100%	15726.40	244 / 245	11%	0.19	53 / 502
esophagus	99%	16512.69	1429 / 1445	11%	0.13	20 / 183
lung	100%	9767.75	576 / 578	9%	0.18	107 / 1155
breast	100%	7989.05	459 / 459	8%	0.13	86 / 1118
thymus	100%	7179.77	650 / 653	7%	0.10	45 / 605
bladder	100%	18765.38	21 / 21	6%	0.16	32 / 504
skin	99%	5953.83	1786 / 1809	7%	0.10	35 / 472
ovary	100%	8346.76	180 / 180	4%	0.06	19 / 430
pancreas	92%	4281.71	303 / 328	12%	0.15	21 / 178
uterus	100%	22322.60	170 / 170	4%	0.08	18 / 459
adrenal gland	100%	6322.84	257 / 258	4%	0.05	9 / 230
brain	86%	3228.33	2276 / 2642	17%	0.26	122 / 705
blood vessel	100%	24899.10	1335 / 1335	0%	0	0 / 0
spleen	100%	8717.68	241 / 241	0%	0	0 / 0
adipose	100%	8606.34	1202 / 1204	0%	0	0 / 0
heart	98%	8086.95	844 / 861	0%	0	0 / 0
peripheral blood	93%	5811.18	861 / 929	0%	0	0 / 0
muscle	89%	3683.84	718 / 803	0%	0	0 / 0
liver	59%	2039.45	133 / 226	1%	0.01	4 / 406
lymph node	0%	0	0 / 0	10%	0.12	3 / 29
eye	0%	0	0 / 0	5%	0.06	4 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042327	Biological process	positive regulation of phosphorylation
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0003151	Biological process	outflow tract morphogenesis
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0021675	Biological process	nerve development
GO_0070527	Biological process	platelet aggregation
GO_0007160	Biological process	cell-matrix adhesion
GO_0010761	Biological process	fibroblast migration
GO_0009967	Biological process	positive regulation of signal transduction
GO_0061351	Biological process	neural precursor cell proliferation
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0030030	Biological process	cell projection organization
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0022011	Biological process	myelination in peripheral nervous system
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0000902	Biological process	cell morphogenesis
GO_0006468	Biological process	protein phosphorylation
GO_0045197	Biological process	establishment or maintenance of epithelial cell apical/basal polarity
GO_0033209	Biological process	tumor necrosis factor-mediated signaling pathway
GO_2000178	Biological process	negative regulation of neural precursor cell proliferation
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005925	Cellular component	focal adhesion
GO_0001725	Cellular component	stress fiber
GO_0030017	Cellular component	sarcomere
GO_0005829	Cellular component	cytosol
GO_0030027	Cellular component	lamellipodium
GO_0106310	Molecular function	protein serine kinase activity
GO_0019901	Molecular function	protein kinase binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ILK
Protein name	Integrin-linked protein kinase (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK) Integrin linked kinase Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)
Synonyms	ILK2 ILK1
Description	FUNCTION: Receptor-proximal protein kinase regulating integrin-mediated signal transduction . May act as a mediator of inside-out integrin signaling . Focal adhesion protein part of the complex ILK-PINCH . This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway . Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells . Regulates cell motility by forming a complex with PARVB . Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B . .
Accessions	ENST00000299421.9 [Q13418-1] ENST00000526114.5 ENST00000537806.5 A0A0A0MTH3 ENST00000526318.2 A0A087WW45 Q13418 ENST00000526711.5 A0A087WWY6 ENST00000627400.1 ENST00000528995.5 [Q13418-2] ENST00000527121.5 ENST00000532063.5 [Q13418-3] ENST00000420936.6 [Q13418-1] E9PQ52 ENST00000396751.6 [Q13418-1]

ILK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review