Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 15 studies | 24% ± 6% | |
| fibroblast | 13 studies | 21% ± 6% | |
| endothelial cell | 8 studies | 24% ± 8% | |
| connective tissue cell | 6 studies | 22% ± 4% | |
| myofibroblast cell | 5 studies | 22% ± 3% | |
| smooth muscle cell | 4 studies | 20% ± 4% | |
| endothelial cell of lymphatic vessel | 4 studies | 18% ± 1% | |
| GABAergic neuron | 3 studies | 17% ± 2% |
Insufficient scRNA-seq data for expression of ADGRA2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 9801.04 | 245 / 245 | 96% | 36.22 | 480 / 502 |
| esophagus | 96% | 3554.54 | 1393 / 1445 | 94% | 21.60 | 172 / 183 |
| breast | 100% | 6345.05 | 459 / 459 | 90% | 16.45 | 1009 / 1118 |
| lung | 100% | 3650.49 | 576 / 578 | 87% | 13.59 | 1003 / 1155 |
| skin | 95% | 5346.52 | 1711 / 1809 | 91% | 27.27 | 431 / 472 |
| intestine | 97% | 3967.35 | 937 / 966 | 87% | 16.17 | 457 / 527 |
| thymus | 98% | 2762.83 | 638 / 653 | 80% | 9.25 | 487 / 605 |
| ovary | 100% | 7720.71 | 180 / 180 | 75% | 11.67 | 321 / 430 |
| stomach | 83% | 2293.15 | 298 / 359 | 92% | 24.54 | 262 / 286 |
| bladder | 100% | 8562.24 | 21 / 21 | 74% | 11.21 | 375 / 504 |
| uterus | 100% | 10465.25 | 170 / 170 | 58% | 14.14 | 266 / 459 |
| kidney | 78% | 1570.83 | 69 / 89 | 70% | 20.82 | 635 / 901 |
| brain | 60% | 735.50 | 1587 / 2642 | 83% | 8.32 | 586 / 705 |
| adrenal gland | 62% | 789.08 | 160 / 258 | 71% | 10.88 | 163 / 230 |
| pancreas | 35% | 445.21 | 116 / 328 | 94% | 28.77 | 168 / 178 |
| adipose | 100% | 5706.14 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 3550.60 | 1318 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 98% | 2216.56 | 237 / 241 | 0% | 0 | 0 / 0 |
| heart | 95% | 2367.49 | 817 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 76% | 11.54 | 61 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 62% | 7.01 | 28 / 45 |
| liver | 15% | 206.60 | 34 / 226 | 40% | 4.69 | 163 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 55% | 6.25 | 16 / 29 |
| muscle | 22% | 255.69 | 176 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_0090210 | Biological process | regulation of establishment of blood-brain barrier |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0045765 | Biological process | regulation of angiogenesis |
| GO_0002040 | Biological process | sprouting angiogenesis |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0043542 | Biological process | endothelial cell migration |
| GO_0050920 | Biological process | regulation of chemotaxis |
| GO_1900747 | Biological process | negative regulation of vascular endothelial growth factor signaling pathway |
| GO_0007417 | Biological process | central nervous system development |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0030175 | Cellular component | filopodium |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_1990909 | Cellular component | Wnt signalosome |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ADGRA2 |
| Protein name | Adhesion G protein-coupled receptor A2 Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) |
| Synonyms | TEM5 GPR124 KIAA1531 |
| Description | FUNCTION: Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) . Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex . ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly . Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate . . |
| Accessions | ENST00000315215.11 [Q96PE1-2] H7C1L1 ENST00000428068.5 Q96PE1 ENST00000412232.3 [Q96PE1-1] |
