Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | WNT2-FZD10+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 2 | WNT2-FZD10+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 3 | WNT2-FZD1+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 4 | WNT2-FZD1+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 5 | WNT2-FZD2+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 6 | WNT2-FZD2+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 7 | WNT2-FZD3+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 8 | WNT2-FZD3+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 9 | WNT2-FZD4+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 10 | WNT2-FZD4+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 11 | WNT2-FZD5+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 12 | WNT2-FZD5+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 13 | WNT2-FZD6+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 14 | WNT2-FZD6+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 15 | WNT2-FZD7+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 16 | WNT2-FZD7+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 17 | WNT2-FZD8+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 18 | WNT2-FZD8+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 19 | WNT2-FZD9+LRP5 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 20 | WNT2-FZD9+LRP6 | WNT2_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 21 | WNT3-FZD10+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 22 | WNT3-FZD10+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 23 | WNT3-FZD1+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 24 | WNT3-FZD1+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 25 | WNT3-FZD2+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 26 | WNT3-FZD2+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 27 | WNT3-FZD3+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 28 | WNT3-FZD3+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 29 | WNT3-FZD4+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 30 | WNT3-FZD4+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 31 | WNT3-FZD5+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 32 | WNT3-FZD5+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 33 | WNT3-FZD6+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 34 | WNT3-FZD6+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 35 | WNT3-FZD7+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 36 | WNT3-FZD7+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 37 | WNT3-FZD8+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 38 | WNT3-FZD8+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 39 | WNT3-FZD9+LRP5 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| 40 | WNT3-FZD9+LRP6 | WNT3_HUMAN - | Ligand-Receptor | Signaling by WNT |
| Name | Wnt signalosome |
| ID | GO_1990909 |
| collection_id | Cellular component |
| Exact synonym | LRP5/6 signalosome, Wnt signalosome complex, Wnt-LRP5/6 signalosome |
| Description | A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. |
| Comment | Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription. |
| External URL | |
| Genes |