AXIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0007605Biological processsensory perception of sound
GO_0060322Biological processhead development
GO_0000209Biological processprotein polyubiquitination
GO_0001701Biological processin utero embryonic development
GO_0031122Biological processcytoplasmic microtubule organization
GO_0010629Biological processnegative regulation of gene expression
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0009950Biological processdorsal/ventral axis specification
GO_0065003Biological processprotein-containing complex assembly
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0032147Biological processactivation of protein kinase activity
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0051248Biological processnegative regulation of protein metabolic process
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0036342Biological processpost-anal tail morphogenesis
GO_0048468Biological processcell development
GO_0006913Biological processnucleocytoplasmic transport
GO_0048320Biological processaxial mesoderm formation
GO_0006915Biological processapoptotic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0044725Biological processepigenetic programming in the zygotic pronuclei
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030877Cellular componentbeta-catenin destruction complex
GO_0005829Cellular componentcytosol
GO_0071944Cellular componentcell periphery
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005938Cellular componentcell cortex
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_1990909Cellular componentWnt signalosome
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0070412Molecular functionR-SMAD binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0046332Molecular functionSMAD binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0002039Molecular functionp53 binding
GO_0070411Molecular functionI-SMAD binding
GO_0005515Molecular functionprotein binding
GO_0070016Molecular functionarmadillo repeat domain binding

IV. Literature review

[source]
Gene nameAXIN1
Protein nameAxin-1 (Axis inhibition protein 1)
Axin-1 (Axis inhibition protein 1) (hAxin)
Axin 1
SynonymsAXIN
LA16c-314G4.3-005
hCG_1984103
DescriptionFUNCTION: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling . Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway . In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B . Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 . Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development . Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation . .

AccessionsB1AH42
A0A0S2Z4M1
ENST00000262320.8 [O15169-1]
O15169
A0A0S2Z4S3
H0Y830
A0A0S2Z4R0
ENST00000457798.1
ENST00000354866.7 [O15169-2]