GO_0090090 | OmnibusX

negative regulation of canonical Wnt signaling pathway

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	DKK1-KREMEN1+LRP6	DKK1_HUMAN -	Ligand-Receptor	Signaling by WNT inhibition
2	WNT11-FRZB	WNT11_HUMAN - SFRP3_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
3	WNT11-FZD1+LRP5	WNT11_HUMAN -	Ligand-Receptor	Signaling by WNT
4	WNT11-FZD1+LRP6	WNT11_HUMAN -	Ligand-Receptor	Signaling by WNT
5	WNT11-FZD6+LRP5	WNT11_HUMAN -	Ligand-Receptor	Signaling by WNT
6	WNT11-FZD6+LRP6	WNT11_HUMAN -	Ligand-Receptor	Signaling by WNT
7	WNT11-SFRP1	WNT11_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
8	WNT11-SFRP2	WNT11_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
9	WNT11-SFRP4	WNT11_HUMAN - SFRP4_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
10	WNT11-SFRP5	WNT11_HUMAN - SFRP5_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
11	WNT5A-FRZB	WNT5A_HUMAN - SFRP3_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
12	WNT5A-FZD6+LRP5	WNT5A_HUMAN -	Ligand-Receptor	Signaling by WNT
13	WNT5A-FZD6+LRP6	WNT5A_HUMAN -	Ligand-Receptor	Signaling by WNT
14	WNT5A-SFRP1	WNT5A_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
15	WNT5A-SFRP2	WNT5A_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
16	WNT5A-SFRP4	WNT5A_HUMAN - SFRP4_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
17	WNT5A-SFRP5	WNT5A_HUMAN - SFRP5_HUMAN	Ligand-Ligand	Signaling by WNT inhibition

II. Literature review

Name	negative regulation of canonical Wnt signaling pathway
ID	GO_0090090
collection_id	Biological process
Alternative ID	GO:0035414
Exact synonym	negative regulation of Wnt receptor signaling pathway through beta-catenin, negative regulation of canonical Wnt receptor signaling pathway, negative regulation of canonical Wnt receptor signalling pathway, negative regulation of canonical Wnt-activated signaling pathway
Description	Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
External URL
Genes	LATS1 SOX10 FOXO3 SFRP4 MAPK14 WWTR1 NKD2 FRMD8P1 DACT1 AMER2 SFRP1 IGFBP2 TMEM131L URS00001DC04F_9606 URS0000554A4F_9606 DRAXIN SHH SMAD4 CBY1 OTUD5 DAB2 TLE2 SHISA6 TLE3 FERMT1 LMBR1L MDK HDAC1 CCDC88C TMEM64 DDIT3 PRICKLE1 LATS2 SFRP5 STK11 SFRP2 LIMD1 DKKL1 TMEM88B CTNND1 TLE7 IGFBP1 BICC1 URS0000272A3D_9606 GSK3B SHISA3 AXIN1 URS00002BBD4E_9606 STK3 SIAH2 STK4 AMER1 GREM1 G3BP1 DKK2 LRP4 NKD1 WNT11 NPHP3 DKK4 BMP2 TBX18 DAB2IP GPC3 MESP1 AMFR NHERF1 PFDN5 APOE FUZ SOSTDC1 TLE1 GLI3 CTNNBIP1 EMD UBAC2 DACT3 PRKN MCC APC TLE6 TLE5 TLE4 DKK3 FZD6 GLI1 MLLT3 DKK1 HECW1 SOX9 MAD2L2 GSK3A WNT5A CTHRC1 NOTCH1 PTPRU SOX17 CSNK1A1L ISL1 ANKRD6 NKX2-5 CDH2 PTPRO CYLD KREMEN1 URS000024463E_9606 JADE1 NOG TMEM88 TNN RBX1 FZD1 URS00004DA9DB_9606 RBMS3 SOX13 AXIN2 SDHAF2 SCYL2 ZNRF3 TCF7L2 NOTUM FOXO1 NPHP4 TMEM196 FRMD8 SOX2 EGR1 CHD8 URS000013D17D_9606 SNAI2 RUVBL2 CTNNB1 FRZB IGFBP6 TPBGL APC2 CAV1 CSNK1A1 INVS URS00004CCA62_9606 IGFBP4 TPBG TMEM170B LZTS2 URS0000355E82_9606 SOST