LZTS2 | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	22% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	8274.07	653 / 653	100%	68.16	605 / 605
skin	100%	6077.08	1809 / 1809	100%	56.45	471 / 472
ovary	100%	9318.98	180 / 180	100%	48.34	429 / 430
esophagus	100%	8424.80	1445 / 1445	99%	31.92	182 / 183
prostate	100%	9218.74	245 / 245	99%	44.14	499 / 502
breast	100%	8292.19	459 / 459	99%	42.10	1111 / 1118
uterus	100%	10874.54	170 / 170	99%	51.92	456 / 459
brain	99%	4813.28	2624 / 2642	100%	36.86	703 / 705
bladder	100%	10319.24	21 / 21	99%	40.44	499 / 504
kidney	100%	5899.51	89 / 89	99%	33.38	890 / 901
intestine	100%	8595.55	966 / 966	98%	27.51	519 / 527
adrenal gland	100%	7858.29	258 / 258	98%	35.64	226 / 230
lung	100%	7065.28	577 / 578	98%	35.20	1136 / 1155
stomach	100%	5743.61	359 / 359	98%	27.04	279 / 286
pancreas	97%	2326.34	318 / 328	99%	37.58	176 / 178
liver	53%	855.95	120 / 226	67%	14.54	271 / 406
adipose	100%	8614.85	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10441.42	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	93.98	80 / 80
spleen	100%	5810.88	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	32.28	45 / 45
ureter	0%	0	0 / 0	100%	53.82	1 / 1
heart	100%	4421.98	857 / 861	0%	0	0 / 0
muscle	97%	2804.52	777 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	17.21	26 / 29
peripheral blood	31%	625.47	286 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0051013	Biological process	microtubule severing
GO_0060682	Biological process	primary ureteric bud growth
GO_1900181	Biological process	negative regulation of protein localization to nucleus
GO_0016055	Biological process	Wnt signaling pathway
GO_0051255	Biological process	spindle midzone assembly
GO_0051168	Biological process	nuclear export
GO_0000281	Biological process	mitotic cytokinesis
GO_0072197	Biological process	ureter morphogenesis
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0048144	Biological process	fibroblast proliferation
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0005813	Cellular component	centrosome
GO_0030496	Cellular component	midbody
GO_0005829	Cellular component	cytosol
GO_0031982	Cellular component	vesicle
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0005515	Molecular function	protein binding

Gene name	LZTS2
Protein name	LZTS2 protein Leucine zipper putative tumor suppressor 2 Leucine zipper tumor suppressor 2 Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Synonyms	LAPSER1 KIAA1813
Description	FUNCTION: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. .
Accessions	B1AL11 ENST00000370220.1 ENST00000454422.2 ENST00000481129.1 B1AL13 ENST00000426584.5 ENST00000370223.7 ENST00000429732.5 B1AL12 ENST00000454422.1 Q9BRK4 Q9BRY6 S4R3W7

LZTS2 report