STK11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STK11 at tissue level.

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0030010Biological processestablishment of cell polarity
GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0070314Biological processG1 to G0 transition
GO_0007283Biological processspermatogenesis
GO_0006470Biological processprotein dephosphorylation
GO_0050772Biological processpositive regulation of axonogenesis
GO_0001558Biological processregulation of cell growth
GO_0048814Biological processregulation of dendrite morphogenesis
GO_0097066Biological processresponse to thyroid hormone
GO_0010212Biological processresponse to ionizing radiation
GO_0051645Biological processGolgi localization
GO_0097484Biological processdendrite extension
GO_0007165Biological processsignal transduction
GO_0006974Biological processDNA damage response
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0043276Biological processanoikis
GO_0033762Biological processresponse to glucagon
GO_0014823Biological processresponse to activity
GO_0050852Biological processT cell receptor signaling pathway
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0071493Biological processcellular response to UV-B
GO_0007409Biological processaxonogenesis
GO_0060770Biological processnegative regulation of epithelial cell proliferation involved in prostate gland development
GO_0032147Biological processactivation of protein kinase activity
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_0001944Biological processvasculature development
GO_0033993Biological processresponse to lipid
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0010508Biological processpositive regulation of autophagy
GO_0034504Biological processprotein localization to nucleus
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0060767Biological processepithelial cell proliferation involved in prostate gland development
GO_1901610Biological processpositive regulation of vesicle transport along microtubule
GO_0006914Biological processautophagy
GO_0045059Biological processpositive thymic T cell selection
GO_0001894Biological processtissue homeostasis
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0030111Biological processregulation of Wnt signaling pathway
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0051726Biological processregulation of cell cycle
GO_0042593Biological processglucose homeostasis
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0030308Biological processnegative regulation of cell growth
GO_0140535Cellular componentintracellular protein-containing complex
GO_0016020Cellular componentmembrane
GO_0030018Cellular componentZ disc
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_1902554Cellular componentserine/threonine protein kinase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0030275Molecular functionLRR domain binding
GO_0000287Molecular functionmagnesium ion binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0002039Molecular functionp53 binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTK11
Protein nameSerine/threonine kinase 11
STK11 [amino acids 371-433]
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine kinase 11 isoform 3
Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)
SynonymsLKB1
PJS
DescriptionFUNCTION: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair . .; FUNCTION: [Isoform 2]: Has a role in spermiogenesis. .

AccessionsA0A0S2Z4C7
A0A1B0GUW2
ENST00000585465.2
K7EMR0
Q9NS52
Q15831
ENST00000585465.3 [Q15831-2]
D4P556
ENST00000652231.1 [Q15831-2]
A0A0S2Z4D1
ENST00000585851.2
ENST00000585748.3
Q5ZEZ1
A0A087WT72
ENST00000326873.12 [Q15831-1]
ENST00000593219.5
K7EQN8