GLI1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GLI1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GLI1 at tissue level.

III. Associated gene sets

GO_0008589Biological processregulation of smoothened signaling pathway
GO_0007224Biological processsmoothened signaling pathway
GO_0009954Biological processproximal/distal pattern formation
GO_0030324Biological processlung development
GO_1902808Biological processpositive regulation of cell cycle G1/S phase transition
GO_0060032Biological processnotochord regression
GO_0045667Biological processregulation of osteoblast differentiation
GO_0060045Biological processpositive regulation of cardiac muscle cell proliferation
GO_0001649Biological processosteoblast differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000345Biological processregulation of hepatocyte proliferation
GO_0030850Biological processprostate gland development
GO_0009913Biological processepidermal cell differentiation
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0009953Biological processdorsal/ventral pattern formation
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0097421Biological processliver regeneration
GO_0021696Biological processcerebellar cortex morphogenesis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045740Biological processpositive regulation of DNA replication
GO_0006355Biological processregulation of DNA-templated transcription
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0021983Biological processpituitary gland development
GO_0048546Biological processdigestive tract morphogenesis
GO_0009611Biological processresponse to wounding
GO_0007286Biological processspermatid development
GO_0007418Biological processventral midline development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005930Cellular componentaxoneme
GO_0097542Cellular componentciliary tip
GO_1990788Cellular componentGLI-SUFU complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0097546Cellular componentciliary base
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0008017Molecular functionmicrotubule binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGLI1
Protein nameGLI family zinc finger 1
GLI-Kruppel family member GLI1 splice variant
Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)
Glioma-associated oncogene 1
SynonymsGLI
DescriptionFUNCTION: Acts as a transcriptional activator . Binds to the DNA consensus sequence 5'-GACCACCCA-3' . Regulates the transcription of specific genes during normal development . Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling . Plays a role in cell proliferation and differentiation via its role in SHH signaling . .; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. .

AccessionsENST00000532291.5
ENST00000528467.1 [P08151-2]
ENST00000528432.1
E9PQQ1
T2HQN2
B1Q2M2
ENST00000228682.7 [P08151-1]
ENST00000546141.5 [P08151-2]
E9PIB9
P08151
ENST00000543426.5 [P08151-3]