Name | GLI-SUFU complex |
ID | GO_1990788 |
collection_id | Cellular component |
Description | A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins. |
Comment | An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay). |
External URL | |
Genes |