I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 10 studies | 36% ± 13% | |
| fibroblast | 6 studies | 23% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 10 studies | 36% ± 13% | |
| fibroblast | 6 studies | 23% ± 8% |
Insufficient scRNA-seq data for expression of GLI2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 3475.28 | 180 / 180 | 85% | 5.76 | 365 / 430 |
| lung | 99% | 690.40 | 571 / 578 | 82% | 6.13 | 946 / 1155 |
| esophagus | 88% | 917.45 | 1271 / 1445 | 87% | 18.39 | 159 / 183 |
| prostate | 99% | 1069.82 | 242 / 245 | 68% | 1.61 | 343 / 502 |
| intestine | 98% | 872.52 | 942 / 966 | 67% | 2.56 | 354 / 527 |
| breast | 89% | 524.30 | 409 / 459 | 72% | 2.09 | 800 / 1118 |
| adrenal gland | 94% | 337.96 | 242 / 258 | 67% | 2.97 | 153 / 230 |
| stomach | 79% | 409.39 | 285 / 359 | 78% | 4.15 | 223 / 286 |
| brain | 59% | 181.69 | 1547 / 2642 | 94% | 4.96 | 661 / 705 |
| uterus | 99% | 1544.70 | 169 / 170 | 52% | 3.47 | 237 / 459 |
| bladder | 100% | 1059.24 | 21 / 21 | 46% | 1.61 | 232 / 504 |
| skin | 98% | 978.12 | 1780 / 1809 | 29% | 1.28 | 137 / 472 |
| thymus | 89% | 358.71 | 584 / 653 | 26% | 1.97 | 159 / 605 |
| kidney | 67% | 275.03 | 60 / 89 | 44% | 1.30 | 399 / 901 |
| pancreas | 10% | 26.24 | 34 / 328 | 90% | 5.49 | 160 / 178 |
| blood vessel | 100% | 926.99 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 90% | 504.56 | 1086 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 83% | 264.30 | 201 / 241 | 0% | 0 | 0 / 0 |
| heart | 73% | 359.37 | 629 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 1.91 | 24 / 45 |
| muscle | 35% | 79.10 | 284 / 803 | 0% | 0 | 0 / 0 |
| liver | 13% | 34.53 | 30 / 226 | 12% | 0.77 | 47 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.28 | 5 / 29 |
| eye | 0% | 0 | 0 / 0 | 16% | 0.27 | 13 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0030879 | Biological process | mammary gland development |
| GO_0021508 | Biological process | floor plate formation |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0009954 | Biological process | proximal/distal pattern formation |
| GO_0021965 | Biological process | spinal cord ventral commissure morphogenesis |
| GO_0030324 | Biological process | lung development |
| GO_0048754 | Biological process | branching morphogenesis of an epithelial tube |
| GO_0007507 | Biological process | heart development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0021517 | Biological process | ventral spinal cord development |
| GO_0048566 | Biological process | embryonic digestive tract development |
| GO_0031069 | Biological process | hair follicle morphogenesis |
| GO_0001822 | Biological process | kidney development |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0021775 | Biological process | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO_0021696 | Biological process | cerebellar cortex morphogenesis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0045740 | Biological process | positive regulation of DNA replication |
| GO_0007389 | Biological process | pattern specification process |
| GO_0048666 | Biological process | neuron development |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0035295 | Biological process | tube development |
| GO_0030902 | Biological process | hindbrain development |
| GO_0001501 | Biological process | skeletal system development |
| GO_0033089 | Biological process | positive regulation of T cell differentiation in thymus |
| GO_0048589 | Biological process | developmental growth |
| GO_0007442 | Biological process | hindgut morphogenesis |
| GO_0021983 | Biological process | pituitary gland development |
| GO_0002076 | Biological process | osteoblast development |
| GO_0021513 | Biological process | spinal cord dorsal/ventral patterning |
| GO_0007418 | Biological process | ventral midline development |
| GO_0007411 | Biological process | axon guidance |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0097542 | Cellular component | ciliary tip |
| GO_1990788 | Cellular component | GLI-SUFU complex |
| GO_0005929 | Cellular component | cilium |
| GO_0005829 | Cellular component | cytosol |
| GO_0097546 | Cellular component | ciliary base |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_1990841 | Molecular function | promoter-specific chromatin binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | GLI2 |
| Protein name | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) GLI2 protein GLI family zinc finger 2 GLI family zinc finger 2 (GLI2 transcription factor) GLI2 |
| Synonyms | THP |
| Description | FUNCTION: Functions as a transcription regulator in the hedgehog (Hh) pathway . Functions as a transcriptional activator . May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development . .; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. .; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. .; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. .; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. .; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 . .; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 . .; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 . .; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 . .; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. . |
| Accessions | ENST00000438299.5 Q6RSW0 A0A7I2PJA1 Q1PSW9 ENST00000418323.6 Q0VGA0 ENST00000452319.6 [P10070-5] ENST00000452692.5 A0A6Q8PH00 ENST00000482119.6 ENST00000445186.5 ENST00000433812.1 Q6RSW2 Q6RSW1 H7C1U2 ENST00000361492.9 ENST00000341310.10 ENST00000437950.5 F2Z2B4 P10070 |
