SUFU report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021776Biological processsmoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO_0035904Biological processaorta development
GO_2000059Biological processnegative regulation of ubiquitin-dependent protein catabolic process
GO_0001947Biological processheart looping
GO_0007165Biological processsignal transduction
GO_0042308Biological processnegative regulation of protein import into nucleus
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0060976Biological processcoronary vasculature development
GO_0003281Biological processventricular septum development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0021775Biological processsmoothened signaling pathway involved in ventral spinal cord interneuron specification
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0001843Biological processneural tube closure
GO_0006355Biological processregulation of DNA-templated transcription
GO_0042994Biological processcytoplasmic sequestering of transcription factor
GO_0043588Biological processskin development
GO_2001040Biological processpositive regulation of cellular response to drug
GO_0007286Biological processspermatid development
GO_0005654Cellular componentnucleoplasm
GO_0097542Cellular componentciliary tip
GO_1990788Cellular componentGLI-SUFU complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0097546Cellular componentciliary base
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0019901Molecular functionprotein kinase binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0008013Molecular functionbeta-catenin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSUFU
Protein nameNegative regulator of hedgehog signaling
Suppressor of fused homolog (SUFUH)
Suppressor of fused homolog
SynonymsUNQ650/PRO1280
DescriptionFUNCTION: Negative regulator in the hedgehog/smoothened signaling pathway . Down-regulates GLI1-mediated transactivation of target genes . Down-regulates GLI2-mediated transactivation of target genes . Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome . Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein . Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) . GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state . Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R . When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) . Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity). .

FUNCTION: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). .

AccessionsA0A6M5WQ99
ENST00000369902.8 [Q9UMX1-1]
A0A223LX15
Q9UMX1
ENST00000369899.6 [Q9UMX1-2]
ENST00000423559.2 [Q9UMX1-3]